Short-term symptomatic and functional outcomes of schizophrenia in Butajira, Ethiopia

Kebede, D.; Alem, A.; Shibre, T.; Negash, A.; Deyassa, N.; Beyero, T.; Medhin, G.

doi:10.1016/j.schres.2005.05.028

« Previous Next »Schizophrenia Research
Volume 78, Issue 2 , Pages 171-185, 15 October 2005

Short-term symptomatic and functional outcomes of schizophrenia in Butajira, Ethiopia

Kebede D.
- Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
- Corresponding author. Current address: WHO-Regional Office for Africa, Brazzaville, Congo.
Alem A.
- Department of Psychiatry, Addis Ababa University, Addis Ababa, Ethiopia
Shibre T.
- Schizophrenia and Bipolar Disorder Project, Addis Ababa University, Addis Ababa, Ethiopia
Negash A.
- Schizophrenia and Bipolar Disorder Project, Addis Ababa University, Addis Ababa, Ethiopia
Deyassa N.
- Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
Beyero T.
- Schizophrenia and Bipolar Disorder Project, Addis Ababa University, Addis Ababa, Ethiopia
Medhin G.
- Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia

Received 15 March 2005; received in revised form 25 May 2005; accepted 27 May 2005.

Abstract

Background

Prospective outcome studies based on a community sample of mostly neuroleptic naive cases of schizophrenia are uncommon.

Objectives

To describe short-term symptomatic and functional outcomes of schizophrenia, and potential predictors of outcome.

Methods

After a baseline assessment, 63 incident and 208 prevalent cases of schizophrenia were followed by a yearly clinical assessment for an average of 2.5 (range 1–4) years. Scores of negative symptoms and positive symptoms were used as indicators of symptomatic outcomes. SF-36 scores of physical and social functioning, and role limitation due to mental health problems were used as indicators of functional outcomes. Several variables were evaluated as potential predictors of outcome in random coefficient models.

Results

Functioning and other measures of health related quality of life were significantly diminished in cases as compared to the general population of the area at baseline and follow up. Of the socio-demographic and clinical factors evaluated, only lower negative and positive symptom scores were significantly associated with improvements in functioning. The level of functioning observed in cases from Butajira was lower than that reported for cases from developed countries.

Conclusions

Our findings are not in accord with other outcome studies that have reported better functional outcome for cases of schizophrenia from developing countries.

Keywords: Schizophrenia, Psychosis, Outcome, Functioning, Disability