Schizophrenia Research
Volume 78, Issue 1 , Pages 45-60, 1 October 2005

Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia

  • C. Ervin Davis

      Affiliations

    • Department of Psychiatry, University of California San Diego, United States
    • ,
  • Dilip V. Jeste

      Affiliations

    • Department of Psychiatry, University of California San Diego, United States
    • Division of Geriatric Psychiatry, Veterans Affairs San Diego Healthcare System, United States
    • ,
  • Lisa T. Eyler

      Affiliations

    • Department of Psychiatry, University of California San Diego, United States
    • Desert Pacific Mental Illness Research Education and Clinical Center, United States
    • Corresponding Author InformationCorresponding author. Mail Code 151B, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161. Tel.: +1 858 552 8585x7666; fax: +1 858 642 1458.

Received 21 April 2004; received in revised form 2 May 2005; accepted 9 May 2005.

Abstract 

We systematically reviewed twentyone functional neuroimaging studies that used longitudinal designs to investigate the effects of medication treatments on brain functioning among patients with schizophrenia. The studies reviewed were comprised of functional magnetic resonance imaging and positron emission tomography research using a baseline and at least one follow-up. The present review summarizes the different effects of medication and disease status on brain function, with attention to functional normalization, specific drug effects, and comparisons of typical versus atypical antipsychotics. Particular emphasis is given to methodological limitations in the existing literature, including lack of reliability data, clinical heterogeneity among studies, and inadequate study designs and statistics. Suggestions are made for improving future longitudinal neuroimaging studies of treatment effects in schizophrenia.

Keywords: Functional neuroimaging, Longitudinal studies, Schizophrenia, Drug treatments

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PII: S0920-9964(05)00199-4

doi:10.1016/j.schres.2005.05.009

Schizophrenia Research
Volume 78, Issue 1 , Pages 45-60, 1 October 2005

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