Schizophrenia Research
Volume 77, Issue 2 , Pages 271-277 , 15 September 2005

IQ stabilization in childhood-onset schizophrenia

Received 24 January 2005 ,Revised 31 March 2005 ,Accepted 4 April 2005.

References 

  1. Addington AM, Gornick M, Duckworth J, Sporn A, Gogtay N, Bobb A, et al. GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD(67)), is associated with childhood-onset schizophrenia and cortical gray matter volume loss. Mol. Psychiatry. 2004;1–8
  2. Addington AM, Gornick M, Sporn AL, Gogtay N, Greenstein D, Lenane M, et al. Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. Biol. Psychiatry. 2004;55:976–980
  3. Alaghband-Rad J, McKenna K, Gordon CT, Albus KE, Hamburger SD, Rumsey JM, et al. Childhood-onset schizophrenia: the severity of premorbid course. J. Am. Acad. Child Adolesc. Psych. 1995;34:1273–1283
  4. Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IO: University of Iowa; 1983;
  5. Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, IO: University of Iowa; 1984;
  6. Asarnow RF, Tanguay PE, Bott L, Freeman BJ. Patterns of intellectual functioning in non-retarded autistic and schizophrenic children. J. Child Psychol. Psychiatry. 1987;28:273–280
  7. Bedwell JS, Keller B, Smith AK, Hamburger S, Kumra S, Rapoport JL. Why does postpsychotic IQ decline in childhood-onset schizophrenia?. Am. J. Psychiatry. 1999;156:1996–1997
  8. David AS, Malmberg A, Brandt L, Allebeck P, Lewis G. IQ and risk for schizophrenia: a population-based cohort study. Psychol. Med. 1997;27:1311–1323
  9. Fuller R, Nopoulos P, Arndt S, O'Leary D, Ho BC, Andreasen NC. Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance. Am. J. Psychiatry. 2002;159:1183–1189
  10. Gogtay N, Sporn A, Clasen LS, Nugent TF, Greenstein D, Nicolson R, et al. Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. Arch. Gen. Psychiatry. 2004;61:17–22
  11. Gold S, Arndt S, Nopoulos P, O'Leary DS, Andreasen NC. Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. Am. J. Psychiatry. 1999;156:1342–1348
  12. Goldberg TE, Weinberger DR. The effects of clozapine on neurocognition: an overview. J. Clin. Psychiatry. 1994;55(Suppl B):88–90
  13. Goldberg TE, Weinberger DR. Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies. J. Clin. Psychiatry. 1996;57(Suppl 9):62–65
  14. Goldberg TE, Greenberg RD, Griffin SJ, Gold JM, Kleinman JE, Pickar D, et al. The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br. J. Psychiatry. 1993;162:43–48
  15. Guy W. Clinical global impressions. In: ECDEU Assessment Manual for Psychopharmacology, revised. Rockville, MD: National Institute of Mental Health; 1976;
  16. Guy W. In: US Department of Health EaW  editors. ECDEU Assessment Manual for Psychopharmacology. Washington DC: US Department of Health, Education and Welfare; 1976;Publication ADM 76-338
  17. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  18. Hintze J. Number Cruncher Statistical Software. 2001;
  19. Hollingshead A, Redlich F. Social Class and Mental Illness: A Community Sample. New York: John Wiley and Sons; 1958;
  20. Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet. 1994;344:1398–1402
  21. Kasper S, Resinger E. Cognitive effects and antipsychotic treatment. Psychoneuroendocrinology. 2003;28(Suppl 1):27–38
  22. Kumra S, Frazier JA, Jacobsen LK, McKenna K, Gordon CT, Lenane MC, et al. Childhood-onset schizophrenia. A double-blind clozapine–haloperidol comparison. Arch. Gen. Psychiatry. 1996;53:1090–1097
  23. Kumra S, Wiggs E, Bedwell J, Smith AK, Arling E, Albus K, et al. Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. Schizophr. Res. 2000;42:135–144
  24. Kurtz MM. Neurocognitive impairment across the lifespan in schizophrenia: an update. Schizophr. Res. 2005;74:15–26
  25. McKenna K, Gordon CT, Lenane M, Kaysen D, Fahey K, Rapoport JL. Looking for childhood-onset schizophrenia: the first 71 cases screened. J. Am. Acad. Child Adolesc. Psych. 1994;33:636–644
  26. Mockler D, Riordan J, Sharma T. Memory and intellectual deficits do not decline with age in schizophrenia. Schizophr. Res. 1997;26:1–7
  27. Nicolson R, Brookner FB, Lenane M, Gochman P, Ingraham LJ, Egan MF, et al. Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia. Am. J. Psychiatry. 2003;160:490–495
  28. Nopoulos P, Flashman L, Flaum M, Arndt S, Andreasen N. Stability of cognitive functioning early in the course of schizophrenia. Schizophr. Res. 1994;14:29–37
  29. Rund BR. A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophr. Bull. 1998;24:425–435
  30. SPSS . SPSS 11.0 Brief Guide. Prentice-Hall, Inc.; 2003;
  31. Strandburg RJ, Marsh JT, Brown WS, Asarnow RF, Guthrie D. Information-processing deficits across childhood- and adult-onset schizophrenia. Schizophr. Bull. 1994;20:685–695
  32. Tan HY, Ang YG. Cognitive decline in preschizophrenia patients. Am. J. Psychiatry. 2004;161:580–581author reply 581
  33. Toulopoulou T, Grech A, Morris RG, Schulze K, McDonald C, Chapple B, et al. The relationship between volumetric brain changes and cognitive function: a family study on schizophrenia. Biol. Psychiatry. 2004;56:447–453
  34. Verbeke G. Linear Mixed Models in Practice: a SAS-Oriented Approuch. 1997;
  35. Wechsler D. Administration and Scoring Manual for the Wechsler Intelligence Scale for Children-Revised. New York, New York: The Psychological Corporation; 1974;
  36. Wechsler D. Administration and Scoring Manual for Wechsler Adult Intelligence Scale-Revised Psychological Corporation. 1981;
  37. Wechsler D. Administration and Scoring Manual for Wechsler Intelligence Scale for Children. Third edition. Psychological Corporation; 1991;
  38. Wechsler D. Administration and Scoring Manual for Wechsler Adult Intelligence Scale. Third edition. San Antonio: The Psychological Corporation; 1997;
  39. Weiss EM, Bilder RM, Fleischhacker WW. The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia. Psychopharmacology (Berl). 2002;162:11–17

PII: S0920-9964(05)00136-2

doi: 10.1016/j.schres.2005.04.002

Schizophrenia Research
Volume 77, Issue 2 , Pages 271-277 , 15 September 2005

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