Schizophrenia Research
Volume 77, Issue 2 , Pages 151-165 , 15 September 2005

Examining the latent structure of negative symptoms: Is there a distinct subtype of negative symptom schizophrenia?

  • Jack J. Blanchard

      Affiliations

    • Department of Psychology, University of Maryland, College Park, MD 20742-4411, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 405 8438; fax: +1 301 314 9566.
  • ,
  • William P. Horan

      Affiliations

    • University of California, Los Angeles, United States
  • ,
  • Lindsay M. Collins

      Affiliations

    • Department of Psychology, University of Maryland, College Park, MD 20742-4411, United States

Received 17 November 2004 ,Revised 20 March 2005 ,Accepted 24 March 2005.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. third ed.. Washington, DC: Author; 1987;rev.
  2. Andreasen NC. Negative symptoms in schizophrenia: definition and reliability. Arch. Gen. Psychiatry. 1982;39:784–788
  3. Andreasen NC. Positive vs. negative schizophrenia: a critical evaluation. Schizophr. Bull. 1985;11:380–389
  4. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M. Symptoms of schizophrenia: methods, meanings, and mechanisms. Arch. Gen. Psychiatry. 1995;52:341–351
  5. Beauchaine TP, Beauchaine RJ. A comparison of maximum covariance and k-means cluster analysis in classifying cases into known taxon groups. Psychol. Methods. 2002;7:245–261
  6. Beauchaine TP, Waters E. Pseudotaxonicity in MAMBAC and MAXCOV analyses of rating-scale data: turning continua into classes by manipulating observers expectations. Psychol. Methods. 2003;8:3–15
  7. Bilder RM, Mukherjee S, Rieder RO, Pandurangi AK. Symptomatic and neuropsychological components of defect states. Schizophr. Bull. 1985;11:409–419
  8. Blanchard JJ, Gangestad SW, Brown SA, Horan WP. Hedonic capacity and schizotypy revisited: a taxometric analysis of social anhedonia. J. Abnorm. Psychology. 2000;109:87–95
  9. Blanchard JJ, Sayers SL, Collins LM, Bellack AS. Affectivity in the problem-solving interactions of schizophrenia patients and their family members. Schizophr. Res. 2004;69:105–117
  10. Bryson G, Whelahan HA, Bell M. Memory and executive function impairments in deficit syndrome schizophrenia. Psychiatry Res. 2001;102:29–37
  11. Buchanan RW, Carpenter WT. Domains of Psychopathology. An approach to the reduction of heterogeneity in schizophrenia. J. Nerv. Ment. Dis. 1994;182:193–204
  12. Buchanan RW, Kirkpatrick B, Heinrichs DW, Carpenter WT. Clinical correlates of the deficit syndrome of schizophrenia. Am. J. Psychiatry. 1990;147:290–294
  13. Carpenter WT, Heinrichs DW, Wagman AMI. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry. 1988;145:578–583
  14. Cleland CM, Rothschild L, Haslam N. Detecting latent taxa: Monte Carlo comparison of taxometric, mixture model, and clustering procedures. Psychol. Rep. 2000;87:37–47
  15. Cohen JD. Statistical Power Analysis for the Behavioral Sciences. second ed.. Hissdale, NJ: Erlbaum; 1988;
  16. Earnst KS, Kring AM. Construct validity of negative symptoms: an empirical and conceptual review. Clin. Psychol. Rev. 1997;17:167–189
  17. Emsley R, Rabinowitz J, Torreman M. The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis. Schizophr. Res. 2003;61:47–57
  18. Fenton WS, McGlashan TH. Testing systems for assessment of negative symptoms in schizophrenia. Arch. Gen. Psychiatry. 1992;49:179–184
  19. Fenton WS, McGlashan TH. Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia. Am. J. Psychiatry. 1994;151:351–356
  20. Fitzgerald PB, de Castella AR, Brewer K, Filia K, Collins J, Davey P, et al. A confirmatory factor analytic evaluation of the pentagonal PANSS model. Schizophr. Res. 2003;61:97–104
  21. Fouldrin G, Jay M, Bonnet-Brilhault F, Menard J-F, Petit M, Thibaut F. Concordance of deficit and non-deficit subtypes in siblings affected with schizophrenia. Psychiatry Res. 2001;102:59–64
  22. Gangestad S, Snyder M. “To carve nature at its joints”: on the existence of discrete classes in personality. Psychol. Rev. 1985;92:317–349
  23. Golden R, Meehl PE. Detection of biological sex: an empirical test of cluster methods. Multivariate Behav. Res. 1980;15:475–496
  24. Haslam N, Kim HC. Categories and continua: a review of taxometric research. Genet. Soc. Gen. Psychol. Monogr. 2002;128:271–320
  25. Heckers S, Goff D, Schacter DL, Savage CR, Fischman AJ, Alpert NM, et al. Functional imaging of memory retrieval in deficit vs. nondeficit schizophrenia. Arch. Gen. Psychiatry. 1999;56:1117–1123
  26. Horan WP, Blanchard JJ. Neurocognitive, social, and emotional dysfunction in deficit syndrome schizophrenia. Schizophr. Res. 2003;65:125–137
  27. Horan WP, Blanchard JJ, Gangestad SW, Kwapil T. The psychometric detection of schizotypy: do putative schizotypy indicators identify the same latent class?. J. Abnorm. Psychology. 2004;113:339–357
  28. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–276
  29. Kay SR, Opler LA, Lindenmayer JP. The Positive and Negative Syndrome Scale (PANSS): rationale and standardization. Br. J. Psychiatry. 1989;155(Suppl. 7):59–65
  30. Kirkpatrick B, Buchanan RW. Anhedonia and the deficit syndrome of schizophrenia. Psychiatry Res. 1990;31:25–30
  31. Kirkpatrick B, Ross DE, Walsh D, Karkowski L, Kendler KS. Family characteristics of deficit and nondeficit schizophrenia in the Roscommon family study. Schizophr. Res. 2000;45:57–64
  32. Kirkpatrick B, Buchanan RW, Ross DE, Carpenter WT. A separate disease within the syndrome of schizophrenia. Arch. Gen. Psychiatry. 2001;58:165–171
  33. Lenzenweger MF. Deeper into the schizotypy taxon: on the robust nature of maximum covariance analysis. J. Abnorm. Psychology. 1999;108:182–187
  34. Lenzenweger MF, Dworkin RH, Wethington E. Models of positive and negative symptoms in schizophrenia: an empirical evaluation of latent structures. J. Abnorm. Psychology. 1989;98:62–70
  35. Loevinger J. Objective tests as instruments of psychological theory. Psychol. Rep. 1957;3:635–694
  36. Meehl PE. MAXCOV-HITMAX: a taxonomic search method for loose genetic syndromes. In:  Meehl PE editors. Psychodiagnosis: Selected Papers. Minneapolis: University of Minnesota Press; 1973;p. 200–224
  37. Meehl PE. Factors and taxa, traits and types, differences of degree and differences in kind. J. Personal. 1992;60:117–174
  38. Meehl PE. Bootstraps taxometrics: solving the classification problem in psychopathology. Am. Psychol. 1995;50:266–275
  39. Meehl PE. Clarifications about taxometric method. Appl. Prev. Psychol. 1999;8:165–174
  40. Meehl PE. Primary and secondary hypohedonia. J. Abnorm. Psychology. 2001;110:188–193
  41. Meehl PE, Golden R. Taxometric methods. In:  Kendall P,  Butcher J editor. Handbook of Research Methods in Clinical Psychology. New York: Wiley; 1982;p. 127–181
  42. Meehl PE, Yonce LJ. Taxometric analysis: I. Detecting taxonicity with two quantitative indicators using means above and below a sliding cut (MAMBAC procedure). Psychol. Rep. 1994;74:1059–1274
  43. Meehl PE, Yonce LJ. Taxometric analysis: II. Detecting taxonicity using covariance of two quantitative indicators in successive intervals of a third indicator (MAXCOV procedure). Psychol. Rep. 1996;78:1091–1227
  44. Mueser KT, Bellack AS, Morrison RL, Wade JH. Gender, social competence, and symptomatology in schizophrenia: a longitudinal analysis. J. Abnorm. Psychology. 1990;99:138–147
  45. Mueser KT, Sayers SL, Schooler NR, Mance RM, Haas GL. A multisite investigation of the reliability of the Scale for the Assessment of Negative Symptoms. Am. J. Psychiatry. 1994;151:1453–1462
  46. Mueser KT, Curran PJ, McHugo GJ. The factor structure of the Brief Psychiatric Rating Scale in schizophrenia. Psychol. Assess. 1997;9:196–204
  47. Mueser KT, Sengupta A, Schooler NR, Bellack AS, Xie H, Glick ID, et al. Family treatment and medication dosage reduction in schizophrenia: effects on patient social functioning, family attitudes, and burden. J. Consult. Clin. Psychol. 2001;69:3–12
  48. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychol. Rep. 1962;10:799–812
  49. Pogue-Geile MF, Keshavan MS. Negative symptomatology in schizophrenia: syndrome and subtype status. In:  Greden JF,  Tandon R editor. Negative Schizophrenic Symptoms: Pathophysiology and Clinical Implications. Washington, DC: American Psychiatric Press; 1991;p. 41–59
  50. Reise SP, Gomel JN. Modeling quantitative variation within latent trait dimensions: application of mixed-measurement to personality assessment. Multivariate Behav. Res. 1995;30:341–358
  51. Ross DE, Thaker GK, Buchanan RW, Lahti AC, Medoff D, Bartko JJ, et al. Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients. Am. J. Psychiatry. 1996;153:1158–1165
  52. Ross DE, Kirkpatrick B, Karkowski LM, Straub RE, McLean CJ, O'Neill FA, et al. Sibling correlation of deficit syndrome in the Irish study of high density schizophrenia families. Am. J. Psychiatry. 2000;157:1071–1076
  53. Roy M-A, Maziade M, Labbe A, Merette C. Male gender is associated with deficit schizophrenia: a meta-analysis. Schizophr. Res. 2001;47:141–147
  54. Ruscio J. Program Code and Documentation Files for Performing Taxometric Analyses and Simulating Comparison Data. Elizabethtown, PA: Elizabethtown College, Department of Psychology; 2004;Available online at www.etown.edu/psychology/faculty/ruscio.htm
  55. Ruscio J, Ruscio AM. A structure-based approach to psychological measurement: matching measurement models to latent structure. Assessment. 2002;9:4–16
  56. Ruscio J, Ruscio AM. Clarifying boundary issues in psychopathology: the role of taxometrics in a comprehensive program of structural research. J. Abnorm. Psychology. 2004;113:24–38
  57. Sayers SL, Curran PJ, Mueser KT. Factor structure and construct validity of the Scale for the Assessment of Negative Symptoms. Psychol. Assess. 1996;8:269–280
  58. Schooler NR, Hogarty GE, Weissman MM. Social Adjustment Scale II. In:  Hargraves WA,  Atkinson CC,  Sorenson JE editor. Resource Materials for Community Mental Health Program Evaluators: DHEW Publication 79-328. Washington, DC: US Government Printing Office; 1979;p. 290–303
  59. Schooler NR, Keith SJ, Severe JB, Matthews SM, Bellack AS, Glick ID, et al. Relapse and rehospitalizaiton during maintenance treatment of schizophrenia: the effects of dose reduction and family treatment. Arch. Gen. Psychiatry. 1997;54:453–463
  60. Shtasel D, Gur RE, Gallacher F, Heimberg C, Gur RC. Gender differences in the clinical expression of schizophrenia. Schizophr. Res. 1992;7:225–231
  61. Smith DA, Mar CM, Turoff BK. The structure of schizophrenic symptoms: a meta-analytic confirmatory factor analysis. Schizophr. Res. 1998;31:57–70
  62. Spitzer RL, Williams JBW, Gibbon M, First MB. User's Guide for the Structured Clinical Interview for DSM-III-R: SCID. Washington, DC: American Psychiatric Association; 1990;
  63. Tyrka A, Cannon TD, Haslam N, Mednick SA, Schulsinger F, Schulsinger H, et al. The latent structure of schizotypy: I. Premorbid indicators of a taxon of individuals at risk for schizophrenia-spectrum disorders. J. Abnorm. Psychology. 1995;104:173–183
  64. Tyrka A, Haslam N, Cannon TD. Detection of a longitudinally-stable taxon of individuals at risk for schizophrenia spectrum disorders. In:  Raine A,  Lencz T,  Mednick SA editor. Schizotypal Personality Disorder. New York: Cambridge University Press; 1995;p. 168–191
  65. Waller NG, Meehl PE. Multivariate Taxometric Procedures: Distinguishing Types From Continua. Newbury Park, CA: Sage; 1998;
  66. Waller NG, Putnam FW, Carlson EB. Types of dissociation and dissociative types: a taxometric analysis of dissociative experiences. Psychol. Methods. 1996;1:300–321
  67. Woerner M, Mannuzza S, Kane JM. Anchoring the BPRS: an aid to improved reliability. Psychopharmacol. Bull. 1988;24:112–117

PII: S0920-9964(05)00133-7

doi: 10.1016/j.schres.2005.03.022

Schizophrenia Research
Volume 77, Issue 2 , Pages 151-165 , 15 September 2005