Schizophrenia Research
Volume 77, Issue 2 , Pages 261-270 , 15 September 2005

Cortical gene expression in the neonatal ventral-hippocampal lesion rat model

  • Albert H.C. Wong

      Affiliations

    • Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    • Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Room 711, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8. Tel.: +1 416 535 8501x4010; fax: +1 416 979 4663.
    • ,
  • Barbara K. Lipska

      Affiliations

    • Clinical Brain Disorders Branch, National Institutes of Mental Health, Bethesda, Maryland, USA
    • ,
  • Olga Likhodi

      Affiliations

    • Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    • ,
  • Ernie Boffa

      Affiliations

    • Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    • ,
  • Daniel R. Weinberger

      Affiliations

    • Clinical Brain Disorders Branch, National Institutes of Mental Health, Bethesda, Maryland, USA
    • ,
  • James L. Kennedy

      Affiliations

    • Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    • ,
  • Hubert H.M. Van Tol

      Affiliations

    • Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    • Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    • Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Received 18 January 2005 ,Revised 4 March 2005 ,Accepted 15 March 2005.

References 

  1. Akanuma N, Saitoh O, et al. Interictal schizophrenia-like psychosis in a patient with double cortex syndrome. J. Neuropsychiatry Clin. Neurosci. 2002;14(2):210–213
  2. Al-Amin HA, Shannon Weickert C, et al. Delayed onset of enhanced MK-801-induced motor hyperactivity after neonatal lesions of the rat ventral hippocampus. Biol. Psychiatry. 2001;49(6):528–539
  3. Chambers RA, Moore J, et al. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology. 1996;15(6):587–594
  4. Chen Y, Dougherty ER, et al. Ratio-based decisions and quantitative analysis of cDNA microarray images. J. Biomed. Opt. 1997;2(4):364–374
  5. Colantuoni C, Purcell AE, et al. High throughput analysis of gene expression in the human brain. J. Neurosci. Res. 2000;59(1):1–10
  6. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 1999;122(Pt 4):593–624
  7. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet. 2003;361(9355):417–419
  8. Hogarty GE. Prevention of relapse in chronic schizophrenic patients. J. Clin. Psychiatry. 1993;54(Suppl):18–23
  9. Laver DR, Cherry CA, et al. The actions of calmodulin antagonists W-7 and TFP and of calcium on the gating kinetics of the calcium-activated large conductance potassium channel of the chara protoplasmic drop: a substate-sensitive analysis. J. Membr. Biol. 1997;155(3):263–274
  10. Lillrank SM, Lipska BK, et al. Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage. J. Neural Transm. 1999;106(2):183–196
  11. Lipska BK, Weinberger DR. Genetic variation in vulnerability to the behavioural effects of neonatal hippocampal damage in rats. Proc. Natl. Acad. Sci. 1995;92:8906–8910
  12. Lipska BK, Weinberger DR. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology. 2000;23(3):223–239
  13. Lipska BK, Jaskiw GE, et al. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic damage: a potential animal model of schizophrenia. Neuropsychopharmacology. 1993;9(1):67–75
  14. Lipska BK, Jaskiw GE, et al. Profrontal cortical and hippocampal modulation of haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviours in the rat. Biol. Psychiatry. 1995;38:255–262
  15. Lipska BK, Swerdlow NR, et al. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology. 1995;122:35–43
  16. Magalhaes-Cardoso MT, Pereira MF, et al. Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. J. Physiol. 2003;549(Pt 2):399–408
  17. Milunsky J, Huang XL, et al. Schizophrenia susceptibility gene locus at Xp22.3. Clin. Genet. 1999;55(6):455–460
  18. Paxinos G, Watson C. The Rat Brain—In Stereotaxic Coordinates. San Diego, CA: Academic Press Inc; 1986;
  19. Riley BP, McGuffin P. Linkage and associated studies of schizophrenia. Am. J. Med. Genet. 2000;97(1):23–44
  20. Sklar P, Pato MT, et al. Genome-wide scan in Portuguese Island families identifies 5q31–5q35 as a susceptibility locus for schizophrenia and psychosis. Mol. Psychiatry. 2004;9(2):213–238
  21. Strausberg RL, Feingold EA, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U. S. A. 2002;99(26):16899–16903
  22. Swerdlow NR, Lipska BK, et al. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in rats. Psychopharmacology. 1995;122:27–34
  23. Viot G, Sonigo P, et al. Neocortical neuronal arrangement in LIS1 and DCX lissencephaly may be different. Am. J. Med. Genet. 2004;126A(2):123–128
  24. Weiss SM, Whawell E, et al. Potential for antipsychotic and psychotomimetic effects of A2A receptor modulation. Neurology. 2003;61(11 Suppl 6):S88–S93
  25. Wong AHC, Buckle CE, et al. Polymorphisms in dopamine receptors: what do they tell us?. Eur. J. Pharmacol. 2000;410:183–203
  26. Wong AH, Macciardi F, et al. Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene. Mol. Psychiatry. 2003;8(2):156–166

PII: S0920-9964(05)00121-0

doi: 10.1016/j.schres.2005.03.011

Schizophrenia Research
Volume 77, Issue 2 , Pages 261-270 , 15 September 2005

Article Tools

* Image Usage & Resolution