Contrasting loxapine to its isomer isoloxapine—the critical role of in vivo D2 blockade in determining atypicality

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Volume 77, Issue 2 , Pages 189-199, 15 September 2005

Contrasting loxapine to its isomer isoloxapine—the critical role of in vivo D₂ blockade in determining atypicality

Sridhar Natesan
- Schizophrenia-PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
Suzi VanderSpek
- Schizophrenia-PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
José N. Nobrega
- Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
- Department of Pharmacology, 1 King's College Circle, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
Robert A. McClelland
- Department of Chemistry, 80 St. George Street, University of Toronto, Toronto, Ontario, Canada, M5S 3H6
Shitij Kapur
- Schizophrenia-PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
- Department of Psychiatry, University of Toronto, 8th Floor, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
- Corresponding author. Centre for Addiction and Mental Health, ARF Site, 33 Russell Street, Toronto, Ontario, Canada, M5S 2S1. Tel.: +1 416 979 6890; fax: +1 416 260 4206.