Schizophrenia Research
Volume 76, Issue 2 , Pages 337-342 , 15 July 2005

Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population

  • Kenji J. Tsuchiya

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Shu Takagai

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Masayoshi Kawai

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Hideo Matsumoto

      Affiliations

    • Department of Psychiatry, Tokai University School of Medicine, Isehara, Japan
    • ,
  • Kazuhiko Nakamura

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Yoshio Minabe

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Norio Mori

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • ,
  • Nori Takei

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    • Division of Psychological Medicine, Institute of Psychiatry, London, UK
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. Tel.: +81 53 435 2295; fax: +81 53 435 3621.

Received 14 December 2004 ,Revised 2 March 2005 ,Accepted 4 March 2005.

References 

  1. Brown AS, Schaefer CA, Wyatt RJ, Begg MD, Goetz R, Bresnahan MA, et al. Paternal age and risk of schizophrenia in adult offspring. Am. J. Psychiatry. 2002;159:1528–1533
  2. Byrne M, Agerbo E, Ewald H, Eaton WW, Mortensen PB. Parental age and risk of schizophrenia: a case-control study. Arch. Gen. Psychiatry. 2003;60:673–678
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  15. Pulver AE, McGrath JA, Liang KY, Lasseter VK, Nestadt G, Wolyniec PS. An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia. Am. J. Med. Genet. 2004;124B:6–9
  16. Sham PC, MacLean CJ, Kendler KS. Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?. Br. J. Psychiatry. 1993;163:627–633
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PII: S0920-9964(05)00090-3

doi: 10.1016/j.schres.2005.03.004

Schizophrenia Research
Volume 76, Issue 2 , Pages 337-342 , 15 July 2005

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