Schizophrenia Research
Volume 76, Issue 2 , Pages 195-198 , 15 July 2005

The association of the HLA in patients with schizophrenia, schizoaffective disorder, and in their biological relatives

  • S.O.V. Nunes

      Affiliations

    • Department of Psychiatry-Londrina State University (UEL), Av Adhemar de Barros, 625, 86050190 Londrina, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 43 33390404; fax: +55 43 33238210.
    • ,
  • S.D. Borelli

      Affiliations

    • Department of Clinical Analysis-Maringá State University (UEM), Brazil
    • ,
  • T. Matsuo

      Affiliations

    • Department of Statistics and Applied Mathematics (UEL), Brazil
    • ,
  • M.A.E. Watanabe

      Affiliations

    • Department of General Pathology (UEL), Brazil
    • ,
  • E.N. Itano

      Affiliations

    • Department of General Pathology (UEL), Brazil

Received 1 February 2005 ,Accepted 10 February 2005.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th Ed.. Washington, DC: American Psychiatric Press; 1994;
  2. Blackwood DH, Muir WJ, Stephenson A, Wentzel J, Ad'hiah A, Walker MJ, et al. Reduced expression of HLA-B35 in schizophrenia. Psychiatr. Genet. 1996;6:51–59
  3. Del Bem C, Vilela J, Crippa J, Labate C, Zuardi A. Confiabilidade da “Entrevista clínica estruturada para o D.S.M.-IV” versão clínica traduzida para o português. Rev. Bras. Psiquiatr. 2001;23(3):156–159
  4. Gattaz W, Beckmann H. O sistema de histocompatibilidade nas esquizofrenias. Arq. Neuro-Psiquiatr. 1982;40(3):224–229
  5. Levinson D, Ekholm B, Balciuniene J, Johanson G, Castensson A, Koisti M, et al. Additional support for schizophrenia linkage on chromosome 6 and 8: a multicenter study. Am. J. Med. Genet. 1996;67:580–594
  6. Li T, Underhill J, Liu X, Sham P, Donaldson P, Murray R, et al. Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population. Schizophr. Res. 2001;49:73–78
  7. Lindholm E, Ekholm B, Balciuniene J, Johansson G, Castensson A, Koisti M, et al. Linkage analysis of large Swedish kindred provides further support for a susceptibility locus for schizophrenia on chromosome 6p23. Am. J. Med. Genet. 1999;88:369–377
  8. Schwab S, Hallmayer J, Freimann J, Lerer B, Albus M, Borrmann-Hassenbach M, et al. Investigation of linkage and association/linkage disequilibrium of HLA-DQA1-DQB1-DRB1-Alleles in 69 sib-pair-and 89 trio-families with schizophrenia. Am. J. Med. Genet. 2002;114:315–320
  9. Wright P, Donaldson P, Underhill J, Chouhuri K, Doheety D, Murray R. Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia. Am. J. Psychiatry. 1996;153:1530–1533
  10. Wright P, Sham PC, Gilvarry CM, Jones PB, Cannon M, Sharma T, et al. Autoimmune diseases in the pedigrees of schizophrenic and controls subjects. Schizophr. Res. 1996;20:261–267
  11. Wright P, Nimgaonkar V, Donaldson P, Murray R. Schizophrenia and HLA: a review. Schizophr. Res. 2001;47:1–12

PII: S0920-9964(05)00070-8

doi: 10.1016/j.schres.2005.02.005

Schizophrenia Research
Volume 76, Issue 2 , Pages 195-198 , 15 July 2005

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