Schizophrenia Research
Volume 77, Issue 1 , Pages 11-24 , 1 September 2005

Schizophrenia and depression: Challenging the paradigm of two separate diseases—A controlled study of schizophrenia, depression and healthy controls

Received 15 December 2004 ,Revised 10 January 2005 ,Accepted 10 January 2005.

References 

  1. Andreasen NC. The scale for the assessment of negative symptoms (SANS). Iowa City: University of Iowa; 1983;
  2. Baynes D, Mulholland C, Cooper SJ, Montgomery RC, MacFlynn G, Lynch G, et al. Depressive symptoms in stable chronic schizophrenia: prevalence and relationship to psychopathology and treatment. Schizophr. Res. 2000;45:47–56
  3. Bebbington P, Wilkins S, Jones PB, Foerster A, Murray R, Toone B, et al. Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study. Br. J. Psychiatry. 1993;162:72–79
  4. Birchwood M, Mason R, Macmillan F, Healy J. Depression, demoralization and control over psychotic illness: a comparison of depressed and non-depressed patients with a chronic psychosis. Psychol. Med. 1993;23:387–395
  5. Crow TJ. Positive and negative schizophrenic symptoms and the role of dopamine. Br. J. Psychiatry. 1980;137:383–386
  6. Crow TJ. Nature of the genetic contribution to psychotic illness: a continuum viewpoint. Acta Psychiatr. Scand. 1990;81:401–408
  7. Dohrenwend BP, Shrout PE, Link BG, Skodol AE, Stueve A. Life events and other possible psychosocial risk factors for episodes of schizophrenia and major depression: a case-control study. In:  Mazure CM editors. Does stress cause psychiatric illness?. Washington, DC: American Psychiatric Press; 1995;p. 43–65
  8. Done D, Crow TJ, Johnstone EC, Sacker A. Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. Br. Med. J. 1994;309:699–703
  9. Done DJ, Sacker A, Crow TJ. Childhood antecedents of schizophrenia and affective illness: intellectual performance at ages 7 and 11. Schizophr. Res. 1994;11:96–97
  10. Elkis H, Friedman L, Wise A, Meltzer HY. Meta-analysis of studies of ventricular enlargement and cortical sulcal prominence in mood disorders. Comparisons with controls or patients with schizophrenia. Arch. Gen. Psychiatry. 1995;52:735–746
  11. Erlenmeyer-Kimling L, Rock D, Squires-Wheeler E, Roberts S, Yang J. Early life precursors of psychiatric outcomes in adulthood of subjects at risk for schizophrenia or affective disorders. Psychiatry Res. 1991;39:239–256
  12. Falloon I, Watt DC, Shepherd M. A comparative controlled trial of pimozide and fluphenazine decanoate in the continuation therapy of schizophrenia. Psychol. Med. 1998;8:59–70
  13. Häfner H. Schizophrenia: still Kraepelin's Dimentia Praecox?. Epidemiol. Psichiatr. Soc. 2004;13.2:99–112
  14. Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, et al. IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr. Res. 1992;6:209–223
  15. Häfner H, Maurer K, Löffler W, Riecher-Rössler A. The influence of age and sex on the onset and early course of schizophrenia. Br. J. Psychiatry. 1993;162:80–86
  16. Häfner H, Löffler W, Maurer K, Riecher-Rössler A, Stein A. IRAOS. Interview für die retrospektive Erfassung des Erkrankungsbeginns und-verlaufs bei Schizophrenie und anderen Psychosen. Bern: Hans Huber Verlag; 1999;
  17. Häfner H, Löffler W, Maurer K, Hambrecht M, an der Heiden W. Depression, negative symptoms, social stagnation and social decline in the early course of schizophrenia. Acta Psychiatr. Scand. 1999;100:105–118
  18. Häfner H, Löffler W, Maurer K, Riecher-Rössler A, Stein A. IRAOS—interview for the retrospective assessment of the onset and course of schizophrenia and other psychoses. Göttingen: Hogrefe and Huber; 2003;
  19. Hanssen M, Bak M, Bijl R, Vollebergh W, Van Os J. Outcome of self-reported psychotic experiences in the general population: a prospective study. In:  Hanssen M editors. A continuous psychosis phenotype: from description to prediction. (South-Limburg Mental Health Research and Teaching Network PHD Series). Maastricht: M.S.S. Hanssen; 2004;p. 95–107
  20. Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes FM. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch. Gen. Psychiatry. 2002;59:521–529
  21. Herz M, Melville C. Relapse in schizophrenia. Am. J. Psychiatry. 1980;137:801–805
  22. Hirayasu Y, Shenton ME, Salisbury DF, Dickey CC, Fischer IA, Mazzoni P, et al. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am. J. Psychiatry. 1998;155:1384–1391
  23. Hirsch SR, Jolley AG. The dysphoric syndrome in schizophrenia and its implications for relapse. Br. J. Psychiatry. 1989;155(Suppl 5):46–50
  24. Hirsch SR, Jolley AG, Barnes TRE, Liddle PF, Curson DA, Patel A, et al. Dysphoric and depressive symptoms in chronic schizophrenia. Schizophr. Res. 1989;2:259–264
  25. Jackson H. Remarks on evolution and dissolution of the nervous system. J. Ment. Sci. 1887;33:25–48
  26. Jones P, Done DJ. From birth to onset: a developmental perspective of schizophrenia in two national birth cohorts. In:  Keshavan MS,  Murray RM editor. Neurodevelopmental models of psychopathology. Cambridge: Cambridge University Press; 1997;p. 119–136
  27. Jones PB, Harvey I, Lewis SW, Toone BK, von Os J, Williams M, et al. Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: an epidemiological approach. Psychol. Med. 1994;24:995–1011
  28. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipilä P. Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: a 28-year follow-up of the 1996 north Finland general population birth cohort. Am. J. Psychiatry. 1998;155:355–364
  29. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study: I. Methods, diagnosis of probands and risk of schizophrenia in relatives. Arch. Gen. Psychiatry. 1993;50:527–540
  30. Kendler KS, Karkowski-Shuman L, Walsh D. The risk for psychiatric illness in siblings of schizophrenics: the impact of psychotic and non-psychotic affective illness and alcoholism in parents. Acta Psychiatr. Scand. 1996;94:49–55
  31. Kitamura T, Okazaki Y, Fujinawa A, Yoshino M, Kasahara Y. Symptoms of psychoses. A factor-analytic study. Br. J. Psychiatry. 1995;166:236–240
  32. Knights A, Hirsch SR. ‘Revealed’ depression and drug treatment for schizophrenia. Arch. Gen. Psychiatry. 1981;38:806–811
  33. Koreen AR, Siris SG, Chakos M, Alvir J, Mayerhoff D, Lieberman J. Depression in first episode schizophrenia. Am. J. Psychiatry. 1993;150:1643–1648
  34. Krabbendam L, Myin-Germeys I, Hanssen M, Bijl RV, De Graaf R, Vollebergh W, et al. Hallucinatory experiences and onset of psychotic disorder: evidence that the risk is mediated by delusion formation. Acta Psychiatr. Scand. 2004;110:264–272
  35. Krabbendam L, Hanssen M, Bak M, Van Os J. Psychotic features in the general population. Risk factors for what?. In:  Gattaz WF,  Häfner H editor. Search for the causes of schizophrenia. vol. V:Darmstadt: Steinkopff-Verlag; 2004;p. 54–78
  36. Kraepelin E. Psychiatrie. 5th edn.. Leipzig: Barth; 1896;
  37. Kraepelin E. Die Erscheinungsformen des Irreseins. Z. Gesamte Neurol. Psychiatr. 1920;62:1–29
  38. Liddle PF. Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol. Med. 1987;17:49–57
  39. Liddle PF. The symptoms of chronic schizophrenia: a re-examination of the positive–negative dichotomy. Br. J. Psychiatry. 1987;151:145–151
  40. Liddle PF, Barnes TRE. Syndromes of chronic schizophrenia. Br. J. Psychiatry. 1990;157:558–561
  41. Löffler W, Häfner H. Dimensionen der schizophrenen Symptomatik. Nervenarzt. 1999;70:416–429
  42. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, et al. Continuity and discontinuity of affective disorders and schizophrenia: results of a controlled family study. Arch. Gen. Psychiatry. 1993;50:871–883
  43. Maier W, Minges J, Lichermann D, Heun R, Franke P. Personality variations in healthy relatives of schizophrenics. Schizophr. Res. 1994;12:81–88
  44. Maier W, Lichtermann D, Franke P, Heun R, Falkai P, Rietschel M. The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophr. Res. 2002;57:259–266
  45. Maier W, Höfgen B, Zobel A, Rietschel M. Genetic models of schizophrenia and bipolar disorder—overlapping inheritance or discrete genotypes?. Eur. Arch. Psychiatry Clin. Neurosci. 2005;(Special Issue, in print)
  46. Malla AK, Norman RMG. Prodromal symptoms in schizophrenia. Br. J. Psychiatry. 1994;164:287–293
  47. Mandel MR, Severe JB, Schooler NR, Gelenberg AJ, Mieske M. Development and prediction of post-psychotic depression in neuroleptic-treated schizophrenics. Arch. Gen. Psychiatry. 1982;39:197–203
  48. Marcelis M, Van Os J, Sham P, Jones P, Gilvarry C, Cannon M, et al. Obstetric complications and familial morbid risk of psychiatric disorders. Am. J. Med. Genet. 1998;81:29–36
  49. Maurer, K., Trendler, G., Schmidt, M., an der Heiden, W., Könnecke, R., Häfner, H., in press. Schizophrenie und depression. Nervenarzt.
  50. McGorry PD, Bell RC, Dudgeon PL, Jackson HJ. The dimensional structure of first episode psychosis: an exploratory factor analysis. Psychol. Med. 1998;28:935–947
  51. Norman RMG, Malla AK. Dysphoric mood and symptomatology in schizophrenia. Psychol. Med. 1991;21:897–903
  52. Olfson M, Mechanic D, Boyer CA, Hansell S, Walkup J, Weiden PJ. Assessing clinical predictions of early rehospitalization in schizophrenia. J. of Nerv. Ment. Dis. 1999;187:721–729
  53. Rabins PV, Lavrisha M. Long-term follow-up and phenomenologic differences distinguish among late-onset schizophrenia, late-life depression, and progressive dementia. Am. J. Geriatr. Psychiatry. 2003;11:589–594
  54. Sax KW, Strakowski SM, Keck PE, Upadhyaya VH, West SA, McElroy SL. Relationships among negative, positive, and depressive symptoms in schizophrenia and psychotic depression. Br. J. Psychiatry. 1996;168:68–71
  55. Siris SG. Depression in schizophrenia: perspective in the era of ‘atypical’ antipsychotic agents. Am. J. Psychiatry. 2000;157:1379–1389
  56. Siris SG, Bench C. Depression and schizophrenia. In:  Hirsch SR,  Weinberger DR editor. Schizophrenia. 2nd edn.. Oxford: Blackwell Publishing; 2003;p. 142–167
  57. Siris SG, Adan F, Cohen M, Mandeli J, Aronson A, Casey E. Postpsychotic depression and negative symptoms: an investigation of syndromal overlap. Am. J. Psychiatry. 1988;145:1532–1537
  58. Taylor MA. Are schizophrenia and affective disorders related? A selective literature review. Am. J. Psychiatry. 1992;149:22–32
  59. Tollefson GD, Andersen SW, Tran PV. The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone. Biol. Psychiatry. 1999;46:365–373
  60. Van Os J, Gilvarry C, Bale R, Van Horn E, Tattan T, White I, et al. A comparison of the utility of dimensional and categorical representations of psychosis. Psychol. Med. 1999;29:595–606
  61. Van Os J, Gilvarry C, Bale R, Van Horn L, White I, Murray RM. To what extent does symptomatic improvement result in better outcome in psychotic illness? UK700 Group. Psychol. Med. 1999;29:1183–1195
  62. Van Os J, Verdoux H, Maurice-Tison S, Gay B, Liraud F, Salamon R, et al. Self-reported psychosis-like symptoms and the continuum of psychosis. Soc. Psychiatry Psychiatr. Epidemiol. 1999;34:459–463
  63. Van Os J, Janssen I, Hanssen M, Bak M, Myin-Germeys I, Marcelis M, et al. Cognitive epidemiology: psychological and social risk mechanisms for psychosis. In:  Häfner H editors. Risk and protective factors in schizophrenia. Darmstadt: Steinkopff; 2002;p. 207–228
  64. Verdoux H, Maurice-Tison S, Gay B, Van Os J, Salamon R, Bourgeois ML. A survey of delusional ideation in primary-care patients. Psychol. Med. 1998;28:127–134
  65. Wassink TH, Flaum M, Nopoulos P, Andreasen NC. Prevalence of depressive symptoms in the early course of schizophrenia. Am. J. Psychiatry. 1999;156:315–316
  66. Weinberger DR. Cell biology of the hippocampal formation in schizophrenia. Biol. Psychiatry. 1999;45:395–402
  67. Wing JK, Cooper JE, Sartorius N. Measurement and classification of psychiatric symptoms: an instruction manual for the PSE and CATEGO program. London: Cambridge University Press; 1974;
  68. Wittchen H-U, Müller N, Schmidtkunz B, Winter S, Pfister H. Erscheinungsformen, Häufigkeit und Versorgung von Depressionen. Fortschr. Med. 2000;118(Sonderheft 1):4–10
  69. Zisook S, McAdams LA, Kuck J, Harris MJ, Bailey A, Patterson TL, et al. Depressive symptoms in schizophrenia. Am. J. Psychiatry. 1999;156:1736–1743

☆ Revised version of an oral presentation entitled “Schizophrenia and depression—A doubly controlled study of onset and course in first admissions for schizophrenia, depression and in healthy controls” given at the 12th Biennial Winter Workshop on Schizophrenia, Davos, February 7–13, 2004.

PII: S0920-9964(05)00038-1

doi: 10.1016/j.schres.2005.01.004

Schizophrenia Research
Volume 77, Issue 1 , Pages 11-24 , 1 September 2005

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