Childhood growth and future development of psychotic disorder among Helsinki high-risk children

Niemi, Laura T.; Suvisaari, Jaana M.; Haukka, Jari K.; Lönnqvist, Jouko K.

doi:10.1016/j.schres.2004.11.004

« Previous Next »Schizophrenia Research
Volume 76, Issue 1 , Pages 105-112, 1 July 2005

Childhood growth and future development of psychotic disorder among Helsinki high-risk children

Laura T. Niemi
- Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
- Corresponding author. Tel.: +358 9 4744 8894; fax: +358 9 4744 8478.
Jaana M. Suvisaari
- Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
- Department of Psychiatry, University of Helsinki, Finland
- Tampere School of Public Health, University of Tampere, Finland
Jari K. Haukka
- Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
- Tampere School of Public Health, University of Tampere, Finland
- National Research and Development Centre for Welfare and Health, Helsinki, Finland
Jouko K. Lönnqvist
- Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
- Tampere School of Public Health, University of Tampere, Finland

Received 29 June 2004; received in revised form 25 October 2004; accepted 3 November 2004.

Abstract

Background

The Helsinki High-Risk (HR) Study is a follow-up study of offspring (born between 1960 and 1964) of all females treated for schizophrenia spectrum disorders in mental hospitals in Helsinki before 1975, and controls.

Aim

To compare childhood growth among HR and control children, and to determine if any patterns in childhood growth predict later development of psychotic disorders within the HR group.

Methods

We accessed growth information from childhood health cards, which we obtained for 114 HR and 53 control offspring. The growth of HR children was compared with that of control children. Within the HR group, we investigated whether any association existed between childhood growth patterns and morbidity from psychotic disorders using logistic regression models.

Results

The HR girls were shorter than controls at birth (p=0.030), but this disparity vanished by age 7. In contrast, HR boys were only slightly shorter at birth than controls, but the height difference increased with age, being statistically significant at 10 years (p=0.020).

Among HR children, the combination of being in the lowest tertile for ponderal index at birth but in the highest tertile for BMI at 7 years predicted later development of schizophrenia (OR 22.8, 95% CI 2.0, >100, p=0.040).

Conclusions

Catch-up growth increases the risk of schizophrenia among offspring of mothers with psychotic disorder. Whether this is an independent risk factor or merely a reflection of some other risk factors needs further research.

Keywords: Schizophrenia, High-risk, Childhood growth