Schizophrenia Research
Volume 76, Issue 1 , Pages 83-87, 1 July 2005

Thiobarbituric acid reactive substances in the cerebrospinal fluid in schizophrenia

  • Andrew O. Skinner

      Affiliations

    • Department of Psychiatry and Behavioral Science University of Louisville School of Medicine 3 East Mill Place Louisville, KY 40222, USA
    • ,
  • Sahebarao P. Mahadik

      Affiliations

    • Department of Psychiatry Medical College of Georgia, USA
    • ,
  • David L. Garver

      Affiliations

    • Department of Psychiatry and Behavioral Science University of Louisville School of Medicine 3 East Mill Place Louisville, KY 40222, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 502 727 5654.
    • Supported in part by VA Merit to Dr. Garver.

Received 8 June 2004; received in revised form 11 October 2004; accepted 14 October 2004.

Abstract 

Increased levels of lipid peroxidation products (thiobarbituric acid reactive substances [TBARS]) are reported in plasma/serum from patients with schizophrenia. CSF TBARS levels were assessed in 10 neuroleptic-free patients with schizophrenia and in 9 normal controls. Controlling for duration of storage, CSF TBARS content was significantly lower in patients with schizophrenia vs. controls (p<0.002). No significant correlations were found between CSF TBARS and patients' age, gender, or duration of illness. The likely source of reported elevated plasma/serum TBARS in schizophrenia is therefore in the periphery. Degeneration of central neuronal membranes in schizophrenia is not supported by the present study.

Keywords: Schizophrenia, Peroxidation, Phospholipids, Thiobarbituric acid reactive substances (TBARS), Essential polyunsaturated fatty acid (EPUFA), Cerebrospinal fluid (CSF)

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PII: S0920-9964(04)00385-8

doi:10.1016/j.schres.2004.10.010

Schizophrenia Research
Volume 76, Issue 1 , Pages 83-87, 1 July 2005

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