Schizophrenia Research
Volume 73, Issue 2 , Pages 193-207 , 1 March 2005

Targeting synapses and myelin in the prevention of schizophrenia

  • T.-U.W. Woo

      Affiliations

    • Massachusetts Mental Health Center, Boston, MA 02115, United States
    • Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
    • Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont 02478, United States. Tel.: +1 617 998 0075; fax: +1 617 998 5007.
    • ,
  • A.L. Crowell

      Affiliations

    • Massachusetts Mental Health Center, Boston, MA 02115, United States
    • Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States
    • Current address: Stanford University School of Medicine, Stanford, CA, USA.

Received 11 June 2004 ,Revised 26 July 2004 ,Accepted 30 July 2004.

References 

  1. Aamodt SM, Constantine-Paton M. The role of neural activity in synaptic development and its implications for adult brain function. Advances in Neurology. 1999;79:133–144
  2. Akbarian S, Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE, et al. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Archives of General Psychiatry. 1995;52:258–266
  3. Allin M, Murray R. Schizophrenia: a neurodevelopmental or neurodegenerative disorder?. [Miscellaneous] Current Opinion in Psychiatry. 2002 (January);15:9–15
  4. Anderson SA, Classey JD, Conde F, Lund JS, Lewis DA. Synchronous development of pyramidal neuron dendritic spines and parvalbumin-immunoreactive chandelier neuron axon terminals in layer III of monkey prefrontal cortex. Neuroscience. 1995;67:7–22
  5. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles Ponto LL, et al. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients. Lancet. 1997;349:1730–1734
  6. Baddeley AD. Working Memory. Oxford: Oxford University Press; 1988;
  7. Bagary MS, Symms MR, Barker GJ, Mutsatsa SH, Joyce EM, Ron MA. Gray and white matter brain abnormalities in first-episode schizophrenia inferred from magnetization transfer imaging. Archives of General Psychiatry. 2003;60:779–788
  8. Barbas H. Architecture and cortical connections of the prefrontal cortex in the rhesus monkey. Advances in Neurology. 1992;57:91–115
  9. Barch DM, Carter CS. Selective attention in schizophrenia: relationship to verbal working memory. Schizophrenia Research. 1998;33:53–61
  10. Barch DM, Sheline YI, Csernansky JG, Snyder AZ. Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. Biological Psychiatry. 2003;53:376–384
  11. Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR American Journal of Neuroradiology. 2000;21:1099–1109
  12. Bartzokis G. Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation. Neuropsychopharmacology. 2002;27:672–683
  13. Bartzokis G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J. Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study. Biological Psychiatry. 2003;53:412–421
  14. Benes FM. Myelination of cortical-hippocampal relays during late adolescence. Schizophrenia Bulletin. 1989;15:585–593
  15. Benes FM, Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology. 2001;25:1–27
  16. Benes FM, Turtle M, Khan Y, Farol P. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Archives of General Psychiatry. 1994;51:477–484
  17. Berardi N, Pizzorusso T, Maffei L. Critical periods during sensory development. Current Opinion in Neurobiology. 2000;10:138–145
  18. Berman KF, Illowsky BP, Weinberger DR. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. Archives of General Psychiatry. 1988;45:616–622
  19. Berman KF, Torrey EF, Daniel DG, Weinberger DR. Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Archives of General Psychiatry. 1992;49:927–934
  20. Bourgeois JP, Goldman-Rakic PS, Rakic P. Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cerebral Cortex. 1994;4:78–96
  21. Burns J, Job D, Bastin ME, Whalley H, Macgillivray T, Johnstone EC, et al. Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. British Journal of Psychiatry. 2003;182:439–443
  22. Callicott JH, Mattay VS, Bertolino A, Finn K, Coppola R, Frank JA, et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cerebral Cortex. 1999;9:20–26
  23. Cannon TD, Gasperoni TL, van Erp TG, Rosso IM. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. American Journal of Medical Genetics. 2001;105:16–19
  24. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD. Functional hypofrontality and working memory dysfunction in schizophrenia. American Journal of Psychiatry. 1998;155:1285–1287
  25. Castensson A, Emilsson L, Sundberg R, Jazin E. Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis. Biological Psychiatry. 2003;54:1212–1221
  26. Cavada C, Goldman-Rakic PS. Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe. Journal of Comparative Neurology. 1989;287:422–445
  27. Chelune GJ, Baer RA. Developmental norms for the Wisconsin Card Sorting test. Journal of Clinical and Experimental Neuropsychology. 1986;8:219–228
  28. Constantine-Paton M, Cline HT. LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become. Current Opinion in Neurobiology. 1998;8:139–148
  29. Cotter D, Landau S, Beasley C, Stevenson R, Chana G, MacMillan L, et al. The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biological Psychiatry. 2002;51:377–386
  30. Cruz DA, Eggan SM, Lewis DA. Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex. Journal of Comparative Neurology. 2003;465:385–400
  31. Davidsson P, Gottfries J, Bogdanovic N, Ekman R, Karlsson I, Gottfries CG, et al. The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Schizophrenia Research. 1999;40:23–29
  32. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Archives of General Psychiatry. 2003;60:443–456
  33. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R. Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Research. 1997;74:129–140
  34. Deutch AY. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. Journal of Neural Transmission. Supplementum. 1992;36:61–89
  35. Diamond A, Goldman-Rakic PS. Comparison of human infants and rhesus monkeys on Piaget's AB task: evidence for dependence on dorsolateral prefrontal cortex. Experimental Brain Research. 1989;74:24–40
  36. Eastwood SL, Burnet PW, Harrison PJ. Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience. 1995;66:309–319
  37. Espinosa de los Monteros A, Kumar S, Zhao P, Huang CJ, Nazarian R, Pan T, et al. Transferrin is an essential factor for myelination. Neurochemical Research. 1999;24:235–248
  38. Espinosa-Jeffrey A, Kumar S, Zhao PM, Awosika O, Agbo C, Huang A, et al. Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat. Developmental Neuroscience. 2002;24:227–241
  39. Esterle TM, Sanders-Bush E. Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. Journal of Neuroscience. 1992;12:4775–4782
  40. Fagiolini M, Hensch TK. Inhibitory threshold for critical-period activation in primary visual cortex. Nature. 2000;404:183–186
  41. Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?. Journal of Psychiatric Research. 1982;17:319–334
  42. Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Molecular Psychiatry. 2003;8:811–820
  43. Funahashi S, Bruce CJ, Goldman-Rakic PS. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. Journal of Neurophysiology. 1989;61:331–349
  44. Funahashi S, Chafee MV, Goldman-Rakic PS. Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task. Nature. 1993;365:753–756
  45. Funahashi S, Bruce CJ, Goldman-Rakic PS. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic “scotomas”. Journal of Neuroscience. 1993;13:1479–1497
  46. Fuster JM. Prefrontal neurons in networks of executive memory. Brain Research Bulletin. 2000;52:331–336
  47. Fuster JM. The prefrontal cortex-an update: time is of the essence. Neuron. 2001;30:319–333
  48. Fuster JM. Frontal lobe and cognitive development. Journal of Neurocytology. 2002;31:373–385
  49. Gao WJ, Newman DE, Wormington AB, Pallas SL. Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: immunocytochemical localization of GABAergic neurons. Journal of Comparative Neurology. 1999;409:261–273
  50. Gao WJ, Wormington AB, Newman DE, Pallas SL. Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: immunocytochemical localization of calbindin- and parvalbumin-containing neurons. Journal of Comparative Neurology. 2000;422:140–157
  51. Garey LJ, Ong WY, Patel TS, Kanani M, Davis A, Mortimer AM, et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry. 1998;65:446–453
  52. Glahn DC, Cannon TD, Gur RE, Ragland JD, Gur RC. Working memory constrains abstraction in schizophrenia. Biological Psychiatry. 2000;47:34–42
  53. Glantz LA, Lewis DA. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity. Archives of General Psychiatry. 1997;54:660–669
  54. Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Archives of General Psychiatry. 2000;57:65–73
  55. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives of General Psychiatry. 1997;54:159–165
  56. Goldman-Rakic PS. Development of cortical circuitry and cognitive function. Child Development. 1987;58:601–622
  57. Goldman-Rakic PS. Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences. 1994;6:348–357
  58. Goldman-Rakic PS. The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1996;351:1445–1453
  59. Goldman-Rakic PS. The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biological Psychiatry. 1999;46:650–661
  60. Goldman-Rakic PS, Selemon LD. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia Bulletin. 1997;23:437–458
  61. Goldman-Rakic PS, Selemon LD, Schwartz ML. Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey. Neuroscience. 1984;12:719–743
  62. Gonzalez-Burgos G, Barrionuevo G, Lewis DA. Horizontal synaptic connections in monkey prefrontal cortex: an in vitro electrophysiological study. Cerebral Cortex. 2000;10:82–92
  63. Gonzalez-Burgos G, Krimer LS, Urban NN, Barrionuevo G, Lewis DA. Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex. Cerebral Cortex. 2004;14:530–542
  64. Grace AA. Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. Journal of Neural Transmission. General Section. 1993;91:111–134
  65. Green MF, Satz P, Ganzell S, Vaclav JF. Wisconsin Card Sorting Test performance in schizophrenia: remediation of a stubborn deficit. American Journal of Psychiatry. 1992;149:62–67
  66. Haas GL, Garratt LS, Sweeney JA. Delay to first antipsychotic medication in schizophrenia: impact on symptomatology and clinical course of illness. Journal of Psychiatric Research. 1998;32:151–159
  67. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:4746–4751
  68. Hanover JL, Huang ZJ, Tonegawa S, Stryker MP. Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. Journal of Neuroscience. 1999;19:RC40
  69. Harrison PJ. On the neuropathology of schizophrenia and its dementia: neurodevelopmental, neurodegenerative or both?. Neurodegeneration. 1995;4:1–12
  70. Hensch TK. Controlling the critical period. Neuroscience Research. 2003;47:17–22
  71. Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998;282:1504–1508
  72. Hickmott PW, Constantine-Paton M. Experimental down-regulation of the NMDA channel associated with synapse pruning. Journal of Neurophysiology. 1997;78:1096–1107
  73. Hof PR, Haroutunian V, Friedrich VL, Byne W, Buitron C, Perl DP, et al. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biological Psychiatry. 2003;53:1075–1085
  74. Hoffman RE, Dobscha SK. Cortical pruning and the development of schizophrenia: a computer model. Schizophrenia Bulletin. 1989;15:477–490
  75. Hoffman RE, McGlashan TH. Parallel distributed processing and the emergence of schizophrenic symptoms. Schizophrenia Bulletin. 1993;19:119–140
  76. Hoffman RE, McGlashan TH. Synaptic elimination, neurodevelopment, and the mechanism of hallucinated “voices” in schizophrenia. American Journal of Psychiatry. 1997;154:1683–1689
  77. Honer WG, Falkai P, Chen C, Arango V, Mann JJ, Dwork AJ. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience. 1999;91:1247–1255
  78. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, et al. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 1999;98:739–755
  79. Huttenlocher PR. Synapse elimination and plasticity in developing human cerebral cortex. American Journal of Mental Deficiency. 1984;88:488–496
  80. Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. Journal of Comparative Neurology. 1997;387:167–178
  81. Hyde TM, Ziegler JC, Weinberger DR. Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis. Archives of Neurology. 1992;49:401–406
  82. Iwai Y, Fagiolini M, Obata K, Hensch TK. Rapid critical period induction by tonic inhibition in visual cortex. Journal of Neuroscience. 2003;23:6695–6702
  83. Kamholz JA. Regulation of myelin development. Multiple Sclerosis. 1996;2:236–240
  84. Karson CN, Mrak RE, Schluterman KO, Sturner WQ, Sheng JG, Griffin WS. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for ‘hypofrontality’. Molecular Psychiatry. 1999;4:39–45
  85. Katz LC. What's critical for the critical period in visual cortex?. Cell. 1999;99:673–676
  86. Katz LC, Shatz CJ. Synaptic activity and the construction of cortical circuits. Science. 1996;274:1133–1138
  87. Keshavan MS. Development, disease and degeneration in schizophrenia: a unitary pathophysiological model. Journal of Psychiatric Research. 1999;33:513–521
  88. Keshavan MS, Anderson S, Pettegrew JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. Journal of Psychiatric Research. 1994;28:239–265
  89. Keshavan MS, Haas G, Miewald J, Montrose DM, Reddy R, Schooler NR, et al. Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses. Schizophrenia Bulletin. 2003;29:757–769
  90. Kubicki M, Westin CF, Maier SE, Frumin M, Nestor PG, Salisbury DF, et al. Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. American Journal of Psychiatry. 2002;159:813–820
  91. Kubicki M, Westin CF, Nestor PG, Wible CG, Frumin M, Maier SE, et al. Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biological Psychiatry. 2003;54:1171–1180
  92. Lehrmann E, Hyde TM, Vawter MP, Becker KG, Kleinman JE, Freed WJ. The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophrenia. Current Molecular Medicine. 2003;3:437–446
  93. Levitt P. Structural and functional maturation of the developing primate brain. Journal of Pediatrics. 2003;143:S35–S45
  94. Levitt JB, Lewis DA, Yoshioka T, Lund JS. Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 and 46). Journal of Comparative Neurology. 1993;338:360–376
  95. Lewis DA. Neural circuitry of the prefrontal cortex in schizophrenia. Archives of General Psychiatry. 1995;52:269–273(discussion 277-268)
  96. Lewis DA. Development of the prefrontal cortex during adolescence: insights into vulnerable neural circuits in schizophrenia. Neuropsychopharmacology. 1997;16:385–398
  97. Lewis DA. Chandelier cells: shedding light on altered cortical circuitry in schizophrenia. Molecular Psychiatry. 1998;3:468–471(466–467)
  98. Lewis DA. GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia. Brain Research. Brain Research Reviews. 2000;31:270–276
  99. Lewis DA, Lieberman JA. Catching up on schizophrenia: natural history and neurobiology. Neuron. 2000;28:325–334
  100. Lewis DA, Levitt P. Schizophrenia as a disorder of neurodevelopment. Annual Review of Neuroscience. 2002;25:409–432
  101. Lieberman JA. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biological Psychiatry. 1999;46:729–739
  102. Lieberman JA, Perkins D, Belger A, Chakos M, Jarskog F, Boteva K, et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biological Psychiatry. 2001;50:884–897
  103. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry. 1999;45:1128–1137
  104. Marta CB, Escobar Cabrera OE, Garcia CI, Villar MJ, Pasquini JM, Soto EF. Oligodendroglial cell differentiation in rat brain is accelerated by the intracranial injection of apotransferrin. Cell and Molecular Biology (Noisy-le-grand). 2000;46:529–539
  105. Marta CB, Paez P, Lopez M, Pellegrino de Iraldi A, Soto EF, Pasquini JM. Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin. Neurochemical Research. 2003;28:101–110
  106. McGlashan TH. The profiles of clinical deterioration in schizophrenia. Journal of Psychiatric Research. 1998;32:133–141
  107. McGlashan TH. Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course?. [see comments.] [erratum appears in Biol Psychiatry 2000 Mar 1;47(5) 473.] Biological Psychiatry. 1999;46:899–907
  108. McGlashan TH, Hoffman RE. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Archives of General Psychiatry. 2000;57:637–648
  109. McGorry PD. Evaluating the importance of reducing the duration of untreated psychosis. Australian and New Zealand Journal of Psychiatry. 2000;34:S145–S149
  110. McGorry PD. The nature of schizophrenia: signposts to prevention. Australian and New Zealand Journal of Psychiatry. 2000;34:S14–S21
  111. McGuire PK, Bates JF, Goldman-Rakic PS. Interhemispheric integration: I. Symmetry and convergence of the corticocortical connections of the left and the right principal sulcus (PS) and the left and the right supplementary motor area (SMA) in the rhesus monkey. Cerebral Cortex. 1991;1:390–407
  112. Melchitzky DS, Sesack SR, Pucak ML, Lewis DA. Synaptic targets of pyramidal neurons providing intrinsic horizontal connections in monkey prefrontal cortex. Journal of Comparative Neurology. 1998;390:211–224
  113. Melchitzky DS, Gonzalez-Burgos G, Barrionuevo G, Lewis DA. Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex. Journal of Comparative Neurology. 2001;430:209–221
  114. Meyer-Lindenberg A, Poline JB, Kohn PD, Holt JL, Egan MF, Weinberger DR, et al. Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American Journal of Psychiatry. 2001;158:1809–1817
  115. Meyer-Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, et al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nature Neuroscience. 2002;5:267–271
  116. Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron. 2000;28:53–67
  117. Mirnics K, Middleton FA, Lewis DA, Levitt P. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends in Neurosciences. 2001;24:479–486
  118. Paez PM, Marta CB, Moreno MB, Soto EF, Pasquini JM. Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system. Developments in Neuroscience. 2002;24:47–58
  119. Pantelis C, Barnes TR, Nelson HE, Tanner S, Weatherley L, Owen AM, et al. Frontal-striatal cognitive deficits in patients with chronic schizophrenia. Brain. 1997;120:1823–1843
  120. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Archives of General Psychiatry. 1992;49:975–982
  121. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry. 1995;52:821–828
  122. Park S, Puschel J, Sauter BH, Rentsch M, Hell D. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biological Psychiatry. 1999;46:392–400
  123. Pearlson GD, Petty RG, Ross CA, Tien AY. Schizophrenia: a disease of heteromodal association cortex?. Neuropsychopharmacology. 1996;14:1–17
  124. Perlstein WM, Carter CS, Noll DC, Cohen JD. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry. 2001;158:1105–1113
  125. Petrides M, Pandya DN. Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience. 1999;11:1011–1036
  126. Pierri JN, Chaudry AS, Woo TU, Lewis DA. Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects. American Journal of Psychiatry. 1999;156:1709–1719
  127. Pongrac J, Middleton FA, Lewis DA, Levitt P, Mirnics K. Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders. Neurochemical Research. 2002;27:1049–1063
  128. Pouille F, Scanziani M. Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science. 2001;293:1159–1163
  129. Pucak ML, Levitt JB, Lund JS, Lewis DA. Patterns of intrinsic and associational circuitry in monkey prefrontal cortex. Journal of Comparative Neurology. 1996;376:614–630
  130. Rademacher J, Engelbrecht V, Burgel U, Freund H, Zilles K. Measuring in vivo myelination of human white matter fiber tracts with magnetization transfer MR. NeuroImage. 1999;9:393–406
  131. Reynolds GP, Beasley CL. GABAergic neuronal subtypes in the human frontal cortex-development and deficits in schizophrenia. Journal of Chemical Neuroanatomy. 2001;22:95–100
  132. Rozas C, Frank H, Heynen AJ, Morales B, Bear MF, Kirkwood A. Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex. Journal of Neuroscience. 2001;21:6791–6801
  133. Salami M, Itami C, Tsumoto T, Kimura F. Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:6174–6179
  134. Saleh MC, Espinosa de los Monteros A, de Arriba Zerpa GA, Fontaine I, Piaud O, Djordjijevic D, et al. Myelination and motor coordination are increased in transferrin transgenic mice. Journal of Neuroscience Research. 2003;72:587–594
  135. Schwartz ML, Goldman-Rakic PS. Callosal and intrahemispheric connectivity of the prefrontal association cortex in rhesus monkey: relation between intraparietal and principal sulcal cortex. Journal of Comparative Neurology. 1984;226:403–420
  136. Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry. 1999;45:17–25
  137. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry. 1995;52:805–818(discussion 819–820)
  138. Selemon LD, Rajkowska G, Goldman-Rakic PS. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method. Journal of Comparative Neurology. 1998;392:402–412
  139. Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, et al. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. American Journal of Psychiatry. 2001;158:234–243
  140. Spence SA, Hirsch SR, Brooks DJ, Grasby PM. Prefrontal cortex activity in people with schizophrenia and control subjects. Evidence from positron emission tomography for remission of ‘hypofrontality’ with recovery from acute schizophrenia. [erratum appears in Br J Psychiatry 1998 Jun;172 543.] British Journal of Psychiatry. 1998;172:316–323
  141. Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet. 2003;362:798–805
  142. Tononi G, Edelman GM. Schizophrenia and the mechanisms of conscious integration. Brain Research. Brain Research Reviews. 2000;31:391–400
  143. Tsuang MT, Stone WS, Faraone SV. Towards the prevention of schizophrenia. Biological Psychiatry. 2000;48:349–356
  144. Tsutsumi M, Sanders-Bush E. 5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor. Journal of Pharmacology and Experimental Therapeutics. 1990;254:253–257
  145. Uranova N, Orlovskaya D, Vikhreva O, Zimina I, Kolomeets N, Vostrikov V, et al. Electron microscopy of oligodendroglia in severe mental illness. Brain Research Bulletin. 2001;55:597–610
  146. Vawter MP, Barrett T, Cheadle C, Sokolov BP, Wood WH, Donovan DM, et al. Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Research Bulletin. 2001;55:641–650
  147. Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Archives of General Psychiatry. 2000;57:237–245
  148. Volk D, Austin M, Pierri J, Sampson A, Lewis D. GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neurons. American Journal of Psychiatry. 2001;158:256–265
  149. Wang XJ. Synaptic reverberation underlying mnemonic persistent activity. Trends in Neurosciences. 2001;24:455–463
  150. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry. 1987;44:660–669
  151. Weinberger DR, Berman KF. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1996;351:1495–1503
  152. Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?. Archives of General Psychiatry. 2002;59:553–558
  153. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry. 1986;43:114–124
  154. Weinberger DR, Berman KF, Illowsky BP. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry. 1988;45:609–615
  155. Woo TUW, Whitehead RE, Melchitzky DS, Lewis DA. A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:5341–5346
  156. Woo TUW, Pucak ML, Kye CH, Matus CV, Lewis DA. Peripubertal refinement of the intrinsic and associational circuitry in monkey prefrontal cortex. Neuroscience. 1997;80:1149–1158
  157. Wright IC, Sharma T, Ellison ZR, McGuire PK, Friston KJ, Brammer MJ, et al. Supra-regional brain systems and the neuropathology of schizophrenia. Cerebral Cortex. 1999;9:366–378
  158. Wyatt RJ. Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin. 1991;17:325–351
  159. Wyatt RJ. Early intervention for schizophrenia: can the course of the illness be altered?. Biological Psychiatry. 1995;38:1–3
  160. Yakovlev PI, Lecours AR. The myelogenetic cycles of regional maturation of the brain. In:  Minowski A editors. Regional Development of the Brain in Early Life. Oxford: Blackwell; 1967;p. 3–69
  161. Yung AR, McGorry PD. The initial prodrome in psychosis: descriptive and qualitative aspects. Australian and New Zealand Journal of Psychiatry. 1996;30:587–599
  162. Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. [Review] [76 refs] Schizophrenia Bulletin. 1996;22:353–370
  163. Zheng W, Knudsen EI. Functional selection of adaptive auditory space map by GABAA-mediated inhibition. Science. 1999;284:962–965

PII: S0920-9964(04)00242-7

doi: 10.1016/j.schres.2004.07.022

Schizophrenia Research
Volume 73, Issue 2 , Pages 193-207 , 1 March 2005

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