Schizophrenia Research
Volume 73, Issue 2 , Pages 281-290 , 1 March 2005

Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses

  • Stephen J. Glatt

      Affiliations

    • Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 858 822 2433; fax: +1 858 822 2469.
    • ,
  • Richard S. Wang

      Affiliations

    • Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States
    • ,
  • Yu-Chi Yeh

      Affiliations

    • Harvard Departments of Epidemiology and Psychiatry, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, United States
    • Department of General Psychiatry, Bali Mental Hospital of the Department of Health of Taiwan, Taipei County, Taiwan
    • ,
  • Ming T. Tsuang

      Affiliations

    • Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States
    • Harvard Departments of Epidemiology and Psychiatry, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, United States
    • VA San Diego Healthcare System, La Jolla, CA, United States
    • ,
  • Stephen V. Faraone

      Affiliations

    • Harvard Departments of Epidemiology and Psychiatry, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, United States
    • Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
    • Department of Psychiatry, Harvard Medical School at the Massachusetts General Hospital; Boston, MA, Unites States

Received 2 April 2004 ,Revised 21 July 2004 ,Accepted 23 July 2004.

References 

  1. Anttila S, Kampman O, et al. NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia. Psychiatric Genetics. 2003;13(2):61–64
  2. Bacanu SA, Devlin B, et al. The power of genomic control. American Journal of Human Genetics. 2000;66(6):1933–1944
  3. Carmine A, Chheda MG, et al. Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits. Psychiatric Genetics. 2003;13(1):23–28
  4. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials. 1986;7(3):177–188
  5. Fan JB, Tang JX, et al. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Molecular Psychiatry. 2002;7(1):100–103
  6. Faraone SV, Tsuang D, et al. Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, NY: Guilford; 1999;
  7. Glatt SJ, Faraone SV, et al. Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. American Journal of Psychiatry. 2003;160(3):469–476
  8. Glatt SJ, Faraone SV, et al. Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia. Molecular Psychiatry. 2003;8(11):911–915
  9. Glatt SJ, Faraone SV, et al. DRD2-141C insertion/deletion polymorphism is not associated with schizophrenia: results of a meta-analysis. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2004;128B(1):21–23
  10. Imai K, Harada S, et al. The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals. BMC Psychiatry. 2001;1(1):1
  11. Kaneko N, Muratake T, et al. Transmission disequilibrium test and haplotype analysis of the NOTCH4 gene in Japanese patients with schizophrenia. Psychiatry and Clinical Neurosciences. 2004;58(2):199–205
  12. Lewis CM, Levinson DF, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder: Part II. Schizophrenia. American Journal of Human Genetics. 2003;73(1):34–48
  13. Luo X, Klempan TA, et al. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry. 2004;55(2):112–117
  14. McGinnis RE, Fox H, et al. Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nature Genetics. 2001;28(2):128–129
  15. Moises HW, Yang L, et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genetics. 1995;11(3):321–324
  16. Sklar P, Schwab SG, et al. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics. 2001;28(2):126–128
  17. Skol AD, Young KA, et al. Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2003;118B(1):8–15
  18. Straub RE, MacLean CJ, et al. A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity. Nature Genetics. 1995;11(3):287–293
  19. Takahashi S, Cui YH, et al. Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples. Biological Psychiatry. 2003;54(2):129–135
  20. Tochigi M, Zhang X, et al. Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2004;128B(1):37–40
  21. Ujike H, Takehisa Y, et al. NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neuroscience Letters. 2001;301(1):41–44
  22. Wang S, Sun CE, et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature Genetics. 1995;10:41–46
  23. Wassink TH, Nopoulos P, et al. NOTCH4 and the frontal lobe in schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2003;118B(1):1–7
  24. Wei J, Hemmings GP. The NOTCH4 locus is associated with susceptibility to schizophrenia. Nature Genetics. 2000;25(4):376–377
  25. Woolf B. On estimating the relation between blood group and disease. Annual Eugenics. 1955;19:251–253
  26. Zhang X, Wei J, et al. Is NOTCH4 associated with schizophrenia?. Psychiatric Genetics. 2004;14(1):43–46

PII: S0920-9964(04)00236-1

doi: 10.1016/j.schres.2004.07.015

Schizophrenia Research
Volume 73, Issue 2 , Pages 281-290 , 1 March 2005

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