Schizophrenia Research
Volume 73, Issue 2 , Pages 311-318 , 1 March 2005

M50 sensory gating predicts negative symptoms in schizophrenia

  • Robert J. Thoma

      Affiliations

    • Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • Department of Psychology, University of New Mexico, Albuquerque, NM 87108, United States
    • Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87108, United States
    • Corresponding Author InformationCorresponding authors. Robert J. Thoma and Jose M. Canive is to be contacted at The New Mexico VA Health Care System VAMC/116A, 1501 San Pedro SE, Albuquerque, NM 87108, United States. Tel.: +1 505 265 1711x5135; fax: +1 505 256 5474.
    • ,
  • Faith M. Hanlon

      Affiliations

    • Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • Department of Psychology, University of New Mexico, Albuquerque, NM 87108, United States
    • ,
  • Sandra N. Moses

      Affiliations

    • Department of Psychology, University of New Mexico, Albuquerque, NM 87108, United States
    • ,
  • Daniel Ricker

      Affiliations

    • Department of Psychology, University of New Mexico, Albuquerque, NM 87108, United States
    • ,
  • Mingxiong Huang

      Affiliations

    • Department of Radiology, University of California, San Diego, CA, United States
    • ,
  • Christopher Edgar

      Affiliations

    • Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States
    • ,
  • Jessica Irwin

      Affiliations

    • Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • ,
  • Fernando Torres

      Affiliations

    • Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • ,
  • Michael P. Weisend

      Affiliations

    • Department of Psychology, University of New Mexico, Albuquerque, NM 87108, United States
    • Department of Radiology, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • ,
  • Lawrence E. Adler

      Affiliations

    • Psychiatry Service, Denver VAMC and Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, United States
    • ,
  • Gregory A. Miller

      Affiliations

    • Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87108, United States
    • Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States
    • Department of Psychiatry, University of Illinois at Urbana-Champaign, Urbana, IL, United States
    • ,
  • Jose M. Canive

      Affiliations

    • Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
    • Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87108, United States
    • Corresponding Author InformationCorresponding authors. Robert J. Thoma and Jose M. Canive is to be contacted at The New Mexico VA Health Care System VAMC/116A, 1501 San Pedro SE, Albuquerque, NM 87108, United States. Tel.: +1 505 265 1711x5135; fax: +1 505 256 5474.

References 

  1. Addington D, Addington J, Schissel B. A depression rating scale for schizophrenics. Schizophr. Res. 1990;3(4):247–251
  2. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol. Psychiatry. 1982;17:639–654
  3. Adler LE, Waldo MC, Tatcher A, Cawthra E, Baker N, Freedman R. Lack of relationship of auditory gating defects to negative symptoms in schizophrenia. Schizophr. Res. 1990;3:131–138
  4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth edition. Washington, DC: American Psychiatric Association; 2000;Test Revision
  5. Andreasen NC. Negative symptoms in schizophrenia: definition and reliability. Arch. Gen. Psychiatry. 1982;39:784–788
  6. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr. Bull. 1993;19(2):233–259
  7. Braff DL, Swerdlow NR, Geyer MA. Symptom correlates of prepulse inhibition deficits in mal schizophrenic patients. Am. J. Psychiatry. 1999;156(4):596–602
  8. Cardenas VA, Gerson J, Fein G. The reliability of P50 suppression as measured by the conditioning testing ratio is vastly improved by dipole modeling. Biol. Psychiatry. 1993;33:335–344
  9. Clementz BA, Blumenfeld LD, Cobb S. The gamma band response may account for poor P50 suppression in schizophrenia. NeuroReport. 1997;8(18):3889–3893
  10. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis-I Disorders Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press; 1996;
  11. Freedman R, Adler LE, Gerhardt GA, Waldo M, Baker N, Rose GM, et al. Neurobiological Studies of sensory gating in schizophrenia. Schizophr. Bull. 1987;13(4):669–678
  12. Hemsley DR. A cognitive model for schizophrenia and its possible neural basis. Acta Psychiatr. Scand. 1994;90(S384):80–86
  13. Hemsley DR. A simple (or simplistic) cognitive model for schizophrenia?. Behav. Res. Ther. 1987;31:633–646
  14. Hemsley DR. What do cognitive deficits have to do with schizophrenic symptoms?. Br. J. Psychiatr. 1977;130:133–167
  15. Huang M, Edgar C, Thoma RJ, Hanlon FM, Moses SN, Lee R, et al. Predicting EEG responses using MEG sources in superior temporal gyrus reveals source anomaly in patients with schizophrenia. Clin. Neurophysiol. 2003;114:835–850
  16. Judd LL, McAdams L, Budnick B, Braff D. Sensory gating deficits in schizophrenia: new results. Am. J. Psychiatry. 1992;149(4):488–493
  17. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr. Bull. 1987;13:261–276
  18. Knight RT, Staines WR, Swick D, Chao LL. Prefrontal cortex regulates inhibition and excitation in disturbed neural networks. Acta Psychol. (Amst.). 1999;101(2–3):159–178
  19. Merrin EL, Floyd TC. Negative symptoms and EEG alpha in schizophrenia: a replication. Schizophr. Res. 1996;19(2–3):151–161(May)
  20. Mueser KT, Douglas MS, Bellack AS, Morrison RL. Assessment of enduring deficit and negative symptom subtypes in schizophrenia. Schizophr. Bull. 1991;17(4):565–582
  21. Nagamoto HT, Adler LE, Waldo MC, Freedman R. Sensory gating in schizophrenics and normal controls: Effects of changing stimulation interval. Biol. Psychiatry. 1989;25:549–561
  22. Oranje B, van Berckel BNM, Kemner C, van Ree JM, Kahn RS, Verbaten MN. P50 suppression and prepulse inhibition of the startle reflex in humans: a correlational study. Biol. Psychiatry. 1999;45:883–890
  23. Potkin SG, Gustavo A, Fleming K, Anand R, Keator D, Carreon D, et al. A PET study of the pathophysiology of negative symptoms in schizophrenia. Am. J. Psychiatry. 2002;159(2):227–237
  24. Reite M, Teale P, Zimmerman J, Davis K, Whalen J. Source localization of a 50 msec latency auditory evoked field component. Electroencephalogr. Clin. Neurophysiol. 1988;70(6):490–498
  25. Rubin P, Hemmingsen R, Holm S, Mollermadsen S, Hertel C, Povlsen UJ, et al. Relationship between brain structure and function in disorders of the schizophrenic spectrum: Single Positron emission computerized tomography, computerized tomography and psychopathology of first episodes. Acta Psychiatr. Scand. 1994;90(4):281–289
  26. Sabri O, Erkwoh R, Schreckenberger M, Owega A, Sass H, Buell U. Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics. Lancet. 1997;349(9067):1735–1745
  27. Sabri O, Erkwoh R, Schreckenberger M, Cremerius U, Schulz G, Dickmann C, et al. Regional cerebral blood flow and negative/positive symptoms in 24 drug naïve schizophrenics. J. Nucl. Med. 1997;38(2):181–188
  28. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, et al. Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch. Gen. Psychiatry. 2000;57(5):471–480
  29. Schwarzkopf SB, Lamberti JS, Smith DA. Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition. Biol. Psychiatry. 1993;33:815–828
  30. Thoma RJ, Hanlon FM, Moses SN, Edgar JC, Huang M, Weisend MP, et al. Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia. Am. J. Psychiatry. 2003;160:1595–1605
  31. Venables P. Input dysfunction in schizophrenia. In:  Mahler A editors. Progress in Experimental Personality Research. Orlando, FL: Academic Press; 1964;p. 1–47
  32. Wible CG, Anderson J, Shenton ME, Kricun A, Hirayasu Y, Tanaka S, et al. Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study. Psychiatry Res. 2001;108(2):65–78
  33. Yuasa S, Kurachi M, Suzuki M, Kadono Y, Matsui M, Saitoh O, et al. Clinical symptoms and regional cerebral blood flow in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 1995;246(1):7–12

PII: S0920-9964(04)00215-4

doi: 10.1016/j.schres.2004.07.001

Schizophrenia Research
Volume 73, Issue 2 , Pages 311-318 , 1 March 2005

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