Schizophrenia Research
Volume 73, Issue 2 , Pages 377-378 , 1 March 2005

Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stress

  • Nadja Schröder

      Affiliations

    • Memory and Neurodegeneration Laboratory, Department of Physiological Sciences, Biosciences Faculty, Catholic University, 90619-900 Porto Alegre, RS, Brazil
    • Corresponding Author InformationCorresponding author. Departmento de Ciências Fisiológicas, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga, 6681, 90619-900 Porto Alegre, RS, Brazil. Tel.: +55 51 3320 3500; fax: +55 51 3320 3612.
    • ,
  • Maria Noêmia M. de Lima

      Affiliations

    • Memory and Neurodegeneration Laboratory, Department of Physiological Sciences, Biosciences Faculty, Catholic University, 90619-900 Porto Alegre, RS, Brazil
    • ,
  • João Quevedo

      Affiliations

    • Experimental Physiopatology Laboratory and Neurotoxicology Laboratory, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil
    • ,
  • Felipe Dal Pizzol

      Affiliations

    • Experimental Physiopatology Laboratory and Neurotoxicology Laboratory, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil
    • ,
  • Rafael Roesler

      Affiliations

    • Preclinical Neuropharmacology Laboratory, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046-900 Porto Alegre, RS, Brazil

Received 2 June 2004 ,Revised 22 June 2004 ,Accepted 25 June 2004.

References 

  1. Beuzen JN, Taylor N, Wesnes K, Wood A. A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers. J. Psychopharmacol. 1999;13:152–158
  2. Duman RS. Synaptic plasticity and mood disorders. Mol. Psychiatry. 2002;7(Suppl. 1):S29–S34
  3. Halim ND, Weickert CS, McClintock BW, Weinberger DR, Lipska BK. Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus. Neuropsychopharmacology. 2004;29:1063–1069
  4. Herrera DG, Yague AG, Johnsen-Soriano S, Bosch-Morell F, Collado-Morente L, Muriach M, et al. Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proc. Natl. Acad. Sci. U. S. A. 2003;100:7919–7924
  5. Polydoro M, Schröder N, Lima MNM, Caldana F, Laranja DC, Bromberg E, et al. Haloperidol- and clozapine-induced oxidative stress in the rat brain. Pharmacol. Biochem. Behav. 2004;78:751–756
  6. Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. 2000;3:238–244
  7. Schröder N, O'Dell SJ, Marshall JF. Neurotoxic methamphetamine regimen severely impairs recognition memory in rats. Synapse. 2003;49:89–96
  8. Yokoyama H, Kasai N, Ueda Y, Niwa R, Konaka R, Mori N, et al. In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic. Free Radic. Biol. Med. 1998;26:1056–1060

PII: S0920-9964(04)00212-9

doi: 10.1016/j.schres.2004.06.015

Schizophrenia Research
Volume 73, Issue 2 , Pages 377-378 , 1 March 2005

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