Schizophrenia Research
Volume 73, Issue 2 , Pages 269-274 , 1 March 2005

Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population

  • Qing-Ying Chen

      Affiliations

    • Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China
    • Bio-X Life Science Research Center, Shanghai Jiaotong University, PO Box 501, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, PR China
    • ,
  • Qi Chen

      Affiliations

    • Bio-X Life Science Research Center, Shanghai Jiaotong University, PO Box 501, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, PR China
    • Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, PR China
    • ,
  • Guo-Yin Feng

      Affiliations

    • Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China
    • ,
  • Klaus Lindpaintner

      Affiliations

    • Roche (China) Ltd, 1100 Long Dong Avenue, Pudong New Area, Shanghai 201203, PR China
    • ,
  • Yi Chen

      Affiliations

    • Liaoning Institute of Mental Health, Liaoning, China
    • ,
  • Xiaodong Sun

      Affiliations

    • Liaoning Institute of Mental Health, Liaoning, China
    • ,
  • Zhengxiong Chen

      Affiliations

    • Guangdong Institute of Mental Health, Guangdong, China
    • ,
  • Zhensong Gao

      Affiliations

    • Guangdong Institute of Mental Health, Guangdong, China
    • ,
  • Jisheng Tang

      Affiliations

    • Shandong Institute of Mental Health, Shandong, China
    • ,
  • Lin He

      Affiliations

    • Bio-X Life Science Research Center, Shanghai Jiaotong University, PO Box 501, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, PR China
    • Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, PR China
    • Corresponding Author InformationCorresponding author. Bio-X Life Science Research Center, Shanghai Jiaotong University, PO Box 501, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, PR China. Tel./fax: +86 21 62822491.

Received 21 May 2004 ,Revised 1 June 2004 ,Accepted 1 June 2004.

References 

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, DSM-III-R. 3d ed., rev.. Washington, DC: American Psychiatric Press; 1987;
  2. Angeloni D, Lindor NM, Pack S, Latif F, Wei MH, Lerman MI. CALL gene is haploinsufficient in a 3p-syndrome patient. Am. J. Med. Genet. 1999;86:482–485
  3. Chaisuksunt V, Campbell G, Zhang Y, Schachner M, Lieberman AR, Anderson PN. The cell recognition molecule CHL1 is strongly upregulated by injured and regenerating thalamic neurons. J. Comp. Neurol. 2000;425:382–392
  4. Chaisuksunt V, Zhang Y, Anderson PN, Campbell G, Vaudano E, Schachner M, et al. Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth-associated protein-43. Neuroscience. 2000;100:87–108
  5. Chen S, Mantei N, Dong L, Schachner M. Prevention of neuronal cell death by neural adhesion molecules L1 and CHL1. J. Neurobiol. 1999;38:428–439
  6. Chua SE, Murray RM. The neurodevelopmental theory of schizophrenia: evidence concerning structure and neuropsychology. Ann. Med. 1996;6:547–555
  7. Cohen NR, Taylor JSH, Scott LB, Guillery RW, Soriano P, Furley AJW. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr. Biol. 1997;7:26–33
  8. Demyanenko GP, Tsai AY, Maness PF. Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice. J. Neurosci. 1999;19:4907–4920
  9. Fransen E, Lemmon V, Van Camp G, Vits L, Coucke P, Willems PJ. CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. Eur. J. Hum. Genet. 1995;3:273–284
  10. Germer S, Higuchi R. High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res. 2000;10:258–266
  11. Greenwood TA, Alexander M, Keck PE. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am. J. Med. Genet. 2001;105:145–151
  12. Hillenbrand R, Molthagen M, Montag D, Schachner M. The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions. Eur. J. Neurosci. 1999;11:813–826
  13. Hovatta I, Lichtermann D, Juvonen H, Suvisaari J, Terwilliger JD, Arajarvi R, et al. Linkage analysis of putative schizophrenia gene candidate regions on chromosomes 3p, 5q, 6p, 8p, 20p and 22q in a population-based sampled Finnish family set. Mol. Psychiatry. 1998;3:452–457
  14. Kurumaji A, Nomoto H, Okano T, Toru M. An association study between polymorphisms of L1CAM gene and schizophrenia in a Japanese sample. Am. J. Med. Genet. 2001;105:99–104
  15. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder: Part II. Schizophrenia. Am. J. Hum. Genet. 2003;73:34–48
  16. Maziade M, Roy MA, Rouillard E, Bissonnette L, Fournier JP, Roy A, et al. A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes. Mol. Psychiatry. 2001;6:684–693
  17. Montag-Sallaz M, Baarke A, Montag D. Aberrant neuronal connectivity in CHL1-deficient mice is associated with altered information processing-related immediate early gene expression. J. Neurobiol. 2003;57:67–80
  18. Poltorak M, Khoja I, Hemperly JJ, Williams JR, el-Mallakh R, Freed WJ. Disturbances in cell recognition molecules (N-CAM and L1 antigen) in the CSF of patients with schizophrenia. Exp. Neurol. 1995;131:266–272
  19. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, et al. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. 1995;60:252–260
  20. Sakurai K, Migita O, Toru M, Arinami T. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. Mol. Psychiatry. 2002;7:412–415
  21. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am. J. Med. Genet. 1996;67:580–594
  22. Schmid RS, Maness PF. In:  Kalverboer AF,  Gramsbergen A editor. Handbook on Brain and Behaviour in Human Development. Groningen, The Netherlands: Kluwer Academic Publishers; 2001;p. 199–218
  23. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 1995;59:97–105
  24. Tang JX, Zhou J, Fan JB. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Mol. Psychiatry. 2003;8:717–718
  25. Vawter MP, Howard AL, Hyde TM, Kleinman JE, Freed WJ. Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia. Mol. Psychiatry. 1999;4:467–475
  26. Vawter MP, Usen N, Thatcher L, Ladenheim B, Zhang P, VanderPutten DM, et al. Characterization of human cleaved N-CAM and association with schizophrenia. Exp. Neurol. 2001;172:29–46
  27. Zapata C, Carollo C, Rodriguez S. Sampling variance and distribution of the D′ measure of overall gametic disequilibrium between multiallelic loci. Ann. Hum. Genet. 2001;65:395–406
  28. Zhang Y, Roslan R, Lang D, Schachner M, Lieberman AR, Anderson PN. Expression of CHL1 and L1 by neurons and glia following sciatic nerve and dorsal root injury. Mol. Cell. Neurosci. 2000;16:71–86

PII: S0920-9964(04)00186-0

doi: 10.1016/j.schres.2004.06.001

Schizophrenia Research
Volume 73, Issue 2 , Pages 269-274 , 1 March 2005

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