Schizophrenia Research
Volume 73, Issue 2 , Pages 297-310 , 1 March 2005

Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia

  • Anke Brockhaus-Dumke

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 Cologne, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 221 478 4001; fax: +49 221 478 3738.
  • ,
  • Indira Tendolkar

      Affiliations

    • Department of Psychiatry, University Medical College Nijmegen, Postbus 9101, 6500 HB Nijmegen
    • FC Donders Centre for Cognitive Neuroimaging, Postbus 9101, 6500 HB Nijmegen
  • ,
  • Ralf Pukrop

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 Cologne, Germany
  • ,
  • Frauke Schultze-Lutter

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 Cologne, Germany
  • ,
  • Joachim Klosterkötter

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 Cologne, Germany
  • ,
  • Stephan Ruhrmann

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 Cologne, Germany

Received 23 March 2004 ,Revised 28 May 2004 ,Accepted 31 May 2004.

References 

  1. American Electroencephalographic Society . Guidelines for standard electrode position nomenclature. J. Clin. Neurophysiol. 1994;11:111–113
  2. Baldeweg T, Klugman A, Gruzelier JH, Hirsch SR. Impairment in frontal but not temporal components of mismatch negativity in schizophrenia. Int. J. Psychophysiol. 2002;43:111–122
  3. Bramon E, Croft RJ, McDonald C, Virdi GK, Gruzelier JG, Baldeweg T, et al. Mismatch negativity in schizophrenia: a family study. Schizophr. Res. 2004;67:1–10
  4. Catts SV, Shelley AM, Ward PB, Liebert B, McConaghy N, Andrews S, et al. Brain potential evidence for an auditory sensory memory deficit in schizophrenia. Am. J. Psychiatry. 1995;152:213–219
  5. Cohen J. Statistical Power Analysis for the Behavioral Science. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988;
  6. Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L. The continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Res. 1989;29:65–85
  7. Davalos DB, Kisley MA, Polk SD, Ross RG. Mismatch negativity in detection of interval duration deviants in schizophrenia. NeuroReport. 2003;14:1283–1286
  8. First MB, Gibbon M, Spitzer RL, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID I). Washington, DC: APA; 1997;
  9. Goldberg TE, Gold JM. Neurocognitive functioning in patients with schizophrenia. In:  Bloom FE,  Kupfer DJ editor. Psychopharmacology: The Fourth Generation in Progress. New York: Raven Press; 1995;p. 553–597
  10. Gratton G, Coles MGH, Donchin E. A new method for off-line removal of ocular artifact. Electroencephalogr. Clin. Neurophysiol. 1983;55:468–484
  11. Gross G, Huber G, Klosterkötter J, Linz M. Bonner Skala für die Beurteilung von Basissymptomen (BSABS; Bonn Scale for the Assessment of Basic Symptoms), Berlin: Springer; 1987;
  12. Hager W. Grundlagen einer Versuchsplanung zur Prüfung empirischer Hypothesen in der Psychologie. In:  Lüer G editors. Allgemeine Experimentelle Psychologie. Stuttgart: Gustav Fischer; 1987;p. 43–264
  13. Hager W, Spies K. Versuchsdurchführung und Versuchsbericht. Göttingen: Hogrefe; 1991;
  14. Hambrecht M, Lammertink M, Klosterkötter J, Pukrop R. Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic. Br. J. Psychiatry. 2002;43:30–37
  15. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test Manual. Odessa: Psychological Assessment Resources; 1993;
  16. Javitt DC, Donechka P, Zylberman I, Ritter W, Vaughan HG. Impairment of early cortical processing in schizophrenia: an event-potential confirmation study. Biol. Psychiatry. 1993;33:513–519
  17. Javitt DC, Doneshka P, Grochowski S, Ritter W. Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch. Gen. Psychiatry. 1995;52:550–558
  18. Javitt DC, Grochowski S, Shelley AM, Ritter W. Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval. Electroencephalogr. Clin. Neurophysiol. 1998;108:143–153
  19. Kathmann N, Frodl-Bauch T, Hegerl U. Stability of the mismatch negativity under different stimulus and attention conditions. Clin. Neurophysiol. 1999;110:317–323
  20. Kirino E, Inoue R. Relationship of mismatch negativity to quantitative EEG and morphological findings in schizophrenia. J. Psychiatr. Res. 1999;33:445–456
  21. Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Arch. Gen. Psychiatry. 2001;58:158–164
  22. Lehrl S. Mehrfach–Wortschatz Intelligenztest: MWT-B (Multiple Choice Vocabulary Intelligence Test). Balingen: Perimed-spitta; 1995;
  23. Lezak MD. Neuropsychological Assessment. 3rd ed.. New York: Oxford University Press; 1995;
  24. Mitchie PT. What has MMN revealed about the auditory system in schizophrenia?. Int. J. Psychophysiol. 2001;42:177–194
  25. Mitchie PT, Budd PT, Todd J, Rock D, Wichmann H, Box J, et al. Duration and frequency mismatch negativity in schizophrenia. Int. J. Psychophysiol. 2000;42:177–194
  26. Näätänen R. The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function. Behav. Brain Sci. 1990;13:201–288
  27. Oades RD, Zerbin D, Dittmann-Balcar A, Eggers C. Auditory event-related potential (ERP) and difference wave topography in schizophrenic patients with/without active hallucinations and delusions: a comparison with young obsessive compulsive disorder (OCD) and healthy subjects. Int. J. Psychophysiol. 1996;22:185–214
  28. Pantelis C, Yucel M, Wood SJ, McGorry PD, Velakoulis D. Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences. Aust. N. Z. J. Psychiatry. 2003;37:399–406
  29. Phillips L, Yung AR, McGorry PD. Identification of young people at risk of psychosis: validation of personal assessment and crisis evaluation clinic intake criteria. Aust. N. Z. J. Psychiatry. 2000;34:S164–S169(suppl.)
  30. Picton TW, Bentin S, Berg P, Donchin E, Hillyard SA, Johnson R, et al. Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology. 2000;37:127–152
  31. Pukrop R, Matuschek E, Ruhrmann S, Brockhaus-Dumke A, Tendolkar I, Bertsch A, et al. Dimensions of working memory dysfunction in schizophrenia. Schizophr. Res. 2003;61:259–268
  32. Reite M, Teale P, Sheeder J, Rojas DC, Schneider EE. Magneto-encephalographic evidence of abnormal early auditory memory function in schizophrenia. Biol. Psychiatry. 1996;40:229–301
  33. Sato Y, Yabe H, Todd J, Michie P, Shinozaki N, Sutoh T, et al. Impairment in activation of a frontal attention-switch mechanism in schizophrenic patients. Biol. Psychol. 2003;62:49–63
  34. Schultze-Lutter, F., 2001. Früherkennung der Schizophrenie anhand subjektiver Beschwerdeschilderungen: ein methodenkritischer Vergleich der Vorhersageleistung nonparametrischer statistischer und alternativer Verfahren zur Generierung von Vorhersagemodellen. PhD Thesis at the Philosophical Faculty of the University of Cologne, Germany. http://www.ub.uni-koeln.de/ediss/archiv/2001/11w1210.pdf.
  35. Shelley AM, Ward PB, Catts SV, Michie PT, Andrews S, McConaghy N. Mismatch negativity: an index of preattentive processing deficit in schizophrenia. Biol. Psychiatry. 1991;30:1059–10762
  36. Shelley AM, Silipo G, Javitt DC. Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction. Schizophr. Res. 1999;37:65–79
  37. Shutara Y, Koga Y, Fujita K, Takeuchi H, Mochida M, Takemasa K. An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia. Brain Topogr. 1996;8:285–289
  38. Spitzer M. The psychopathology, neuropsychology, and neurobiology of associative and working memory in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 1993;243:57–70
  39. Spreen O, Strauss E. A compendium of neuropsychological tests. Administrations, Norms, and Commentary. 2nd ed.. Oxford, NY: Oxford University Press; 1998;
  40. Todd J, Michie PT, Budd TW, Rock D, Jablensky AV. Auditory sensory memory in schizophrenia: inadequate trace formation?. Psychiatry Res. 2000;96:99–115
  41. Todd J, Michie PT, Jablensky AV. Association between reduced duration mismatch negativity (MMN) and raised temporal discrimination thresholds in schizophrenia. Clin. Neurophysiol. 2003;114:2061–2070
  42. Umbricht D, Koller R, Schmid L, Skrabo A, Grubel C, Huber T, et al. How specific are deficits in mismatch negativity generation to schizophrenia?. Biol. Psychiatry. 2003;53:1120–1131
  43. Volz H-P, Nenadic I, Gaser C, Rammsayer T, Häger F, Sauer H. Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty. NeuroReport. 2001;12:313–316
  44. Wood SJ, Pantelis C, Proffitt T, Phillips LJ, Stuart GW, Buchanan J-A, et al. Spatial working memory ability is a marker of risk-for-psychosis. Psychol. Med. 2003;33:1239–1247

PII: S0920-9964(04)00185-9

doi: 10.1016/j.schres.2004.05.016

Schizophrenia Research
Volume 73, Issue 2 , Pages 297-310 , 1 March 2005