Schizophrenia Research
Volume 73, Issue 2 , Pages 229-233 , 1 March 2005

Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

  • Ruth Spinks

      Affiliations

    • Schizophrenia Research Center, University of Iowa, United States
    • Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, United States
    • Corresponding Author InformationCorresponding author. University of Iowa, Psychiatry Research, 2-126E MEB, Iowa City IA 52242, United States.
    • ,
  • Peg Nopoulos

      Affiliations

    • Schizophrenia Research Center, University of Iowa, United States
    • Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, United States
    • ,
  • Julie Ward

      Affiliations

    • Department of Psychiatry, Dartmouth College, United States
    • ,
  • Rebecca Fuller

      Affiliations

    • Department of Psychiatry, University of Maryland, United States
    • ,
  • Vincent A. Magnotta

      Affiliations

    • Schizophrenia Research Center, University of Iowa, United States
    • Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, United States
    • ,
  • Nancy C. Andreasen

      Affiliations

    • Schizophrenia Research Center, University of Iowa, United States
    • Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, United States
    • MIND Institute and Departments of Psychiatry and Neurology, University of New Mexico, Albuquerque, NM, United States

Received 2 October 2003 ,Revised 25 April 2004 ,Accepted 6 May 2004.

References 

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  3. Blanton RE, Levitt J, Thompson PM, Badrtalei S, Capetillo-Cunliffe L, Toga AW. Average 3-dimensional caudate surface representations in a juvenile-onset schizophrenia and normal pediatric population. NeuroImage Abstracts. 1999;9:s621
  4. Chakos MH, Lieberman JA, Bilder RM, Borenstein M, Lerner G, Bogerts B, et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. American Journal of Psychiatry. 1994;151:1430–1436
  5. Farde L, Wiesel FA, Stone-Elander S, Halldin C, Nordstom AL, Hall H, et al. D2 dopamine receptors in neuroleptic-naïve schizophrenic patients: a positron emission tomography study with [11] raclopride. Archives of General Psychiatry. 1990;47:213–219
  6. Frazier JA, Giedd JN, Hamberger SD, Albus KE, Kaysen D, Vaituzis AC, et al. Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Archives of General Psychiatry. 1996;53:617–624
  7. Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilder W, et al. A follow-up magnetic resonance imaging study of schizophrenia: relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry. 1998;55:145–152
  8. Gur RE, Maany V, Mozley PD, Swanson C, Bilker W, Gur RC. Subcortical MRI volumes in neuroleptic-naïve and treated patients with schizophrenia. American Journal of Psychiatry. 1998;155:1711–1717
  9. Harris G, Andreasen NC, Cizadlo T, Bailey J, Bockholt HJ, Magnotta VA, et al. Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection. Journal of Computer Assisted Tomography. 1999;23:144–154
  10. Heckers S. Neuropathology of schizophrenia: cortex, thalamus, basal ganglia, and neurotransmitter specific projection systems. Schizophrenia Bulletin. 1997;23:403–421
  11. Hokama HH, Shenton ME, Nestor PG, Kikinis R, Levitt JJ, Metcalf D, et al. Caudate, putamen and globus pallidus volume in schizophrenia: a quantitative MRI study. Psychiatry Research, Neuroimaging. 1995;61:209–229
  12. Hulshoff HE, Schnack Hugo G, Mandl RCW, van Haren NEM, Koning H, Collins DL, et al. Focal gray matter density changes in schizophrenia. Archives of General Psychiatry. 2001;58:1118–1125
  13. Iosifescu DV, Shenton ME, Warfield SK, Kikinis R, Dengler J, Jolesz FA, et al. An automated registration algorithm for measuring MRI subcortical brain structures. NeuroImage. 1997;6:13–25
  14. Magnotta VA, Harris G, Andreasen NC, O'Leary DS, Yuh WTC, Heckle D. Structural MR image processing using the BRAINS2 toolbox. Computerized Medical Imaging and Graphics. 2002;26:251–264
  15. Scheepers FE, deWied CC, Hulshoff PHE, van de Flier W, van der Linden JA, Kahn RS. The effect of clozapine on caudate nucleus volume in schizophrenic patients previously treated with typical antipsychotics. Neuropsychopharmacology. 2001;24:47–54
  16. Velakoulis D, Wood SJ, Smith DJ, Sousby B, Brewer W, Leeton L, et al. Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulated grey matter in patients with chronic schizophrenia. Schizophrenia Research. 2002;57:43–49
  17. Ward J, Magnotta V, Andreasen NC, Ooteman W, Nopoulos P, Pierson R. Color enhancement of multispectral magnetic resonance images: improving the visualization of subcortical structures. Journal of Computer Assisted Tomography. 2001;25:942–949
  18. Woods RP, Grafton ST, Watson JD, Scotte NL, Mazziotta JC. Automated image registration: II. Intersubject validation of linear and nonlinear models. Journal of Computer Assisted Tomography. 1998;22:153–165
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PII: S0920-9964(04)00181-1

doi: 10.1016/j.schres.2004.05.020

Schizophrenia Research
Volume 73, Issue 2 , Pages 229-233 , 1 March 2005

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