Schizophrenia Research
Volume 73, Issue 2 , Pages 253-256 , 1 March 2005

FOXP2 polymorphisms in patients with schizophrenia

  • Julio Sanjuan

      Affiliations

    • Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Universitat de València, Blasco Ibaez 15, 46010 Valencia, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 963983379; fax: +34 963864767.
    • ,
  • Amparo Tolosa

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Jose Carlos González

      Affiliations

    • Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Universitat de València, Blasco Ibaez 15, 46010 Valencia, Spain
    • ,
  • Eduardo Jesus Aguilar

      Affiliations

    • Hospital de Sagunto, Sagunto 46520, Valencia, Spain
    • ,
  • Maria Dolores Moltó

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Carmen Nájera

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Rosa de Frutos

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain

Received 28 April 2004 ,Revised 26 May 2004 ,Accepted 26 May 2004.

References 

  1. Alarcon M, Cantor RM, Liu J, Gilliam TC, Geschwind DH. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. Am. J. Hum. Genet. 2002;70:60–71
  2. Crow TJ. Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Res. Brain Res. Rev. 2000;31:118–129
  3. Crow TJ. Handedness, language lateralisation and anatomical asymmetry: relevance of protocadherin XY to hominid speciation and the aetiology of psychosis. Point of view. Br. J. Psychiatry. 2002;181:295–297
  4. DeLisi LE. Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language. Schizophr. Bull. 2001;27:481–496
  5. Enard W, Przeworski M, Fisher SE, Lai CS, Wiebe V, Kitano T. Molecular evolution of FOXP2, a gene involved in speech and language. Nature. 2002;418:869–872
  6. Gauthier J, Joober R, Mottron L, Laurent S, Fuchs M, De Kimpe V, et al. Mutation screening of FOXP2 in individuals diagnosed with autistic disorder. Am. J. Med. Genet. 2003;15:172–175
  7. Haddock G, McCarron J, Tarrier N, Faragher EB. Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol. Med. 1999;29:879–888
  8. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet. 2003;361:417–419
  9. Krawiecka M, Goldberg D, Vaughan M. A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatr. Scand. 1977;55:299–308
  10. Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP. A forkhead domain gene is mutated in a severe speech and language disorder. Nature. 2001;413:519–523
  11. Liegeois F, Baldeweg T, Connelly A, Gadian DG, Mishkin M, Vargha-Khadem F. Language fMRI abnormalities associated with FOXP2 gene mutation. Nat. Neurosci. 2003;6:1230–1237
  12. Marcus GF, Fisher SE. FOXP2 in focus: what can genes tell us about speech and language. Trends. Cogn. Sci. 2003;7:257–262
  13. Newbury DF, Bonora E, Lamb JA, Fisher SE, Lai CS, Baird G, et al. FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am. J. Hum. Genet. 2002;70:1318–1327
  14. Wassink TH, Piven J, Vieland VJ, et al. Evaluation of FOXP2 as an autism susceptibility gene. Am. J. Med. Genet. 2002;114:566–569
  15. Wong AHC, Van Tol HHM. Schizophrenia: from phenomenology to neurobiology. Neurosci. Biobehav. Rev. 2003;27:269–306
  16. Zhang J, Webb DM, Podlaha O. Accelerated protein evolution and origins of human-specific features: Foxp2 as an example. Genetics. 2002;162:1825–1835

PII: S0920-9964(04)00177-X

doi: 10.1016/j.schres.2004.05.012

Schizophrenia Research
Volume 73, Issue 2 , Pages 253-256 , 1 March 2005

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