Schizophrenia Research
Volume 73, Issue 2 , Pages 253-256, 1 March 2005

FOXP2 polymorphisms in patients with schizophrenia

  • Julio Sanjuan

      Affiliations

    • Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Universitat de València, Blasco Ibaez 15, 46010 Valencia, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 963983379; fax: +34 963864767.
    • ,
  • Amparo Tolosa

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Jose Carlos González

      Affiliations

    • Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Universitat de València, Blasco Ibaez 15, 46010 Valencia, Spain
    • ,
  • Eduardo Jesus Aguilar

      Affiliations

    • Hospital de Sagunto, Sagunto 46520, Valencia, Spain
    • ,
  • Maria Dolores Moltó

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Carmen Nájera

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain
    • ,
  • Rosa de Frutos

      Affiliations

    • Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, Spain

Received 28 April 2004; received in revised form 26 May 2004; accepted 26 May 2004.

Abstract 

Background

FOXP2 was described as the first gene involved in our ability to acquire spoken language. The main objective of this study was to compare the distribution of FOXP2 gene polymorphisms between patients with schizophrenia and healthy controls.

Methods

Two FOXP2 polymorphisms, Intron3a and SNP 923875, and the G→A transition in exon 14 were analysed in 149 patients with schizophrenia and schizoaffective disorders according to DSM-IV, as well as in 137 controls. All the patients showed a history of auditory hallucinations.

Results

The transition G→A at exon 14, detected in all the affected members in KE family, was not found in any of the analyzed samples from patients or controls. No significant differences were found between individual controls and patients for the two analysed polymorphisms.

Conclusions

This study would not support a possible role of the two FOXP2 analyzed polymorphisms in the vulnerability to schizophrenia.

Keywords: FOXP2, Schizophrenia, Polymorphisms, Language, Evolutionary

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PII: S0920-9964(04)00177-X

doi:10.1016/j.schres.2004.05.012

Schizophrenia Research
Volume 73, Issue 2 , Pages 253-256, 1 March 2005

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