A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population

Received 28 November 2003; accepted 21 January 2004.

Abstract

Studies have shown a strong positive association between schizophrenia and G72/G30, demonstrated by both individual markers and haplotypes. A further functional study also supports the role of G72 in the etiology of schizophrenia. In this study, we have replicated these results of transmission/disequilibrium testing (TDT) and haplotype analysis in the Han Chinese population, showing P values of 0.0018 and 0.00007 for individual markers and haplotypes, respectively. Hence, our data supports the hypothesis that G72/G30 are important candidate genes for explaining schizophrenia in the Han Chinese population.

Keywords: G72, SNP, Haplotype, Family trios, Linkage disequilibrium

a Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, PR China

b Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, PR China

c Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, PR China

d Xi'an Institute of Mental Health, Xi'an, PR China

Corresponding author. Bio-X Life Science Research Center, Shanghai JiaoTong University, P.O. Box 501, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, PR China. Tel.: +86-21-62822491; fax: +86-21-62822491.

PII: S0920-9964(04)00048-9

doi:10.1016/j.schres.2004.01.015

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