Schizophrenia Research
Volume 73, Issue 2 , Pages 383-385 , 1 March 2005

A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men

  • Ryota Hashimoto

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-42-341-2712x5831; fax: +81-42-346-1744.
    • Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8502, Japan
    • ,
  • Mariko Yoshida

      Affiliations

    • Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8502, Japan
    • ,
  • Norio Ozaki

      Affiliations

    • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yoshio Yamanouchi

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    • ,
  • Nakao Iwata

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    • ,
  • Tatsuyo Suzuki

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    • ,
  • Tsuyoshi Kitajima

      Affiliations

    • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    • ,
  • Masahiko Tatsumi

      Affiliations

    • Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    • ,
  • Kunitoshi Kamijima

      Affiliations

    • Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    • ,
  • Hiroshi Kunugi

      Affiliations

    • Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8502, Japan

Received 11 November 2003 ,Accepted 21 January 2004.

References 

  1. Caloca MJ, Wang H, Kazanietz MG. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a ‘non-protein kinase C’ phorbol ester receptor. Biochem. J. 2003;375:313–321
  2. DeLisi LE. Critical overview of current approaches to genetic mechanisms in schizophrenia research. Brain Res. Brain Res. Rev. 2000;31:187–192
  3. Futamura T, Toyooka K, Iritani S, Niizato K, Nakamura R, Tsuchiya K, et al. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Mol. Psychiatry. 2002;7:673–682
  4. Futamura T, Kakita A, Tohmi M, Sotoyama H, Takahashi H, Nawa H. Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development. Mol. Psychiatry. 2003;8:19–29
  5. Haga H, Yamada R, Ohnishi Y, Nakamura Y, Tanaka T. Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J. Hum. Genet. 2002;47:605–610
  6. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet. 2003;361:417–419
  7. Hashimoto, R., Straub, R.E., Weickert, C.S., Hyde, T.M., Kleinman, J.E., Weinberger, D.R. 2003. Expression Analysis of Neuregulin-1 in the Dorsolateral Prefrontal Cortex in Schizophrenia. Mol Psychiatry advance online publication.
  8. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, et al. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-α gene in Japanese patients with schizophrenia. J. Neural Transm. 2004;111:217–221
  9. Negishi M, Katoh H. Rho family GTPases as key regulators for neuronal network formation. J. Biochem. (Tokyo). 2002;132:157–166
  10. Ramakers GJ. Rho proteins, mental retardation and the cellular basis of cognition. Trends Neurosci. 2002;25:191–199
  11. Yuan S, Miller DW, Barnett GH, Hahn JF, Williams BR. Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. Cancer Res. 1995;55:3456–3461

PII: S0920-9964(04)00046-5

doi: 10.1016/j.schres.2004.01.017

Schizophrenia Research
Volume 73, Issue 2 , Pages 383-385 , 1 March 2005

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