Schizophrenia Research
Volume 71, Issue 1 , Pages 191-193 , 1 November 2004

Hypothesis: Do insulin-like growth factors underlie associations of birth complications, fetal and pre-adult growth with schizophrenia?

  • D. Gunnell

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +44-117-928-7253; fax: +44-117-928-7204.

Received 15 October 2002 ,Accepted 19 July 2003.

References 

  1. Berkman DS, Lescano AG, Gilman RH, Lopez SL, Black MM. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet. 2002;359:564–571
  2. Catts VS, Catts SV. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?. Schizophr. Res. 2000;41:405–415
  3. Chang S, Spitz MR, Yu H, Xifeng W. Insulin-like growth factors (IGFs) in post-menopausal women: looking closely at body size and reproductive factors. Proc. AACR. 2001;42:
  4. Davey Smith G, Gunnell D, Holly J. Insulin-like growth factor-I and cancer. Epidemiological insights into a potential mechanism linking environment and cancer risk. BMJ. 2000;321:847–848
  5. DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, et al. A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am. J. Psychiatry. 2002;159:803–812
  6. Doublier S, Duyckaerts C, Seurin D, Binoux M. Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1. Growth Horm. IGF Res. 2000;10:267–274
  7. Fall CHD, Pandit AN, Law CM, Yajnik CS, Clark PM, Breier B, et al. Size at birth and plasma insulin-like growth factor-1 concentrations. Arch. Dis. Child. 1995;73:287–293
  8. Gluckman PD, Guan J, Williams C, Scheepens A, Zhang R, Bennet L, et al. Asphyxial brain injury—the role of the IGF system. Mol. Cell. Endocrinol. 1998;140:95–99
  9. Guevara-Aguirre J, Rosenbloom AL, Fielder PJ, Diamond FB, Rosenfeld RG. Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations. J. Clin. Endocrinol. Metab. 1993;76:417–423
  10. Gunnell D, Rasmussen F, Fouskakis D, Tynelius P, Harrison G. Patterns of fetal and childhood growth and the development of psychosis in young males: a cohort study. Am. J. Epidemiol. 2003;
  11. Holly JMP, Gunnell DJ, Davey Smith G. Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?. J. Endocrinol. 1999;162:321–330
  12. Jernström H, Olsson H. Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women. Int. J. Gynecol. Obstet. 1998;62:11–18
  13. Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jorgensen K, et al. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J. Clin. Endocrinol. Metab. 1994;78:744–752
  14. Kaklamani VG, Linos A, Kaklamani E, Markaki I, Koumantaki Y, Mantzoros CS. Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults. J. Clin. Oncol. 1999;17:3291–3298
  15. Kunugi H, Nanko S, Murray RM. Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment. Br. J. Psychiatry. 2001;40:S25–S29
  16. Laron Z, Klinger B. Laron syndrome: clinical features, molecular pathology and treatment. Horm. Res. 1994;42:198–202
  17. Le Roith D. Insulin-like growth factors. N. Engl. J. Med. 1997;336:633–640
  18. Lichtermann D, Ekelund J, Pukkala E, Tanskanen A, Lonnqvist J. Incidence of cancer among persons with schizophrenia and their relatives. Arch. Gen. Psychiatry. 2001;58:573–578
  19. Niblock MM, Brunso-Bechtold JK, Riddle DR. Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex. J. Neurosci. 2000;20:4165–4176
  20. Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol. Genomics. 2000;4:83–91
  21. Nopoulos P, Flaum M, Arndt S, Andreasen N. Morphometry in schizophrenia revisited: height and its relationship to pre-morbid function. Psychol. Med. 1998;28:655–663
  22. Ong K, Kratzsch J, Kiess W, Costello M, Scott C, Dunger D. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. J. Clin. Endocrinol. Metab. 2000;85:4266–4269
  23. Richards M, Hardy R, Kuh D, Wadsworth ME. Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study. BMJ. 2001;322:199–203
  24. Singer K, Chang PT, Hsu GL. Physique, personality and mental illness in the southern Chinese. Br. J. Psychiatry. 1972;121:315–319
  25. Torres-Aleman I. Serum growth factors and neuroprotective surveillance: focus on IGF-1. Mol. Neurobiol. 2000;21:153–160
  26. Tsuang MT, Stone WS, Faraone SV. Genes, environment and schizophrenia. Br. J. Psychiatry. 2001;40:S18–S24
  27. Vatten LJ, Odeg RA, Nilsen ST, Salvesen K, Austgulen R. Relationship of insulin-like growth factor-I and insulin-like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birthweight. Obstet. Gynaecol. 2002;99:85–90
  28. Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch. Gen. Psychiatry. 2001;58:48–52
  29. Ward KE, Friedman L, Wise A, Schulz SC. Meta-analysis of brain and cranial size in schizophrenia. Schizophr. Res. 1996;22:197–213
  30. Woods KA, Camacho-Hubner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N. Engl. J. Med. 1996;335:1363–1367
  31. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J. Natl. Cancer Inst. 2000;92:1472–1489

PII: S0920-9964(03)00224-X

doi: 10.1016/S0920-9964(03)00224-X

Schizophrenia Research
Volume 71, Issue 1 , Pages 191-193 , 1 November 2004

Article Tools