Schizophrenia Research
Volume 69, Issue 1 , Pages 121-123 , 1 July 2004

Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in utero

  • S.Hossein Fatemi

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-612-626-3633; fax: +1-612-624-8935.
    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    • ,
  • Mohsen Araghi-Niknam

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    • ,
  • Jessica A. Laurence

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    • ,
  • Joel M. Stary

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    • ,
  • Robert W. Sidwell

      Affiliations

    • Institute of Antiviral Research, Utah State University, Logan, UT, USA
    • ,
  • Susanne Lee

      Affiliations

    • Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA

,Accepted 7 February 2003.

References 

  1. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am. J. Psychiatry. 2002;159(7):1080–1092
  2. Chess S. Follow-up report on autism in congenital rubella. J. Autism Child. Schizophrenia. 1977;7(1):69–81
  3. Erlander MG, Tillakaratne NJK, Feldblum S, Patel N, Tobin A. Two genes encode distinct glutamate decarboxylases. Neuron. 1991;7:91–100
  4. Fatemi SH, Emamian ES, Kist D, Sidwell R, Akhter P, Sheikh S, et al. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally-infected neonatal mice. Mol. Psychiatry. 1999;4:145–154
  5. Fatemi SH, Cuadra A, El-Fakahany E, Sidwell RW. Prenatal viral infection causes alterations in nNOS expression in developing mouse brains. NeuroReport. 2000;11:1493–1496
  6. Fatemi SH, Emamian ES, Sidwell RW, Kist DA, Earle J, Bailey K. Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice. Mol. Psychiatry. 2002;7:633–640
  7. Fatemi SH, Earle J, Kanodia R, Kist D, Emamian ES, Patterson PH, et al. Prenatal viral infection leads to pyramidal cell atrophy, macrocephaly and abnormal behavior in adulthood: implications for genesis of autism and schizophrenia. Cell. Mol. Neurobiol. 2002;22:25–33
  8. Fatemi SH, Laurence J, Araghi-Niknam M, Stary JM, Rizvi S. Glial fibrillary acidic protein is elevated in superior frontal and parietal cortices of autistic subjects. Int. J. Neuropsychopharmacol. 2002;5(S1):153–154
  9. Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR. Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Biol. Psychiatry. 2002;52:805–810
  10. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J. Neurosci. 2003;23(1):297–302

PII: S0920-9964(03)00175-0

doi: 10.1016/S0920-9964(03)00175-0

Schizophrenia Research
Volume 69, Issue 1 , Pages 121-123 , 1 July 2004

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