Schizophrenia Research
Volume 67, Issue 1 , Pages 111-113 , 1 March 2004

Failure to find association between PRODH deletion and schizophrenia

  • Tsuyuka Ohtsuki

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • Syunsuke Tanaka

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • Hiroki Ishiguro

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • Ei-ichi Tanabe

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Kazuo Yara

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Tatsunobu Okubo

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Sakae Takahashi

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Masato Matsuura

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Tei-ichiro Sakai

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Mariko Muto

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Eisuke Matsushima

      Affiliations

    • Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
    • ,
  • Emiko Noguchi

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • Michio Toru

      Affiliations

    • Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
    • ,
  • Toshiya Inada

      Affiliations

    • Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, Nagoya 466-8550, Japan
    • ,
  • Takuya Kojima

      Affiliations

    • Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • ,
  • Tadao Arinami

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-29-853-3352; fax: +81-29-853-3333.
    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

Received 2 May 2003

References 

  1. Arinami T, Ohtsuki T, Takase K, Shimizu H, Yoshikawa T, Horigome H, et al. Screening for 22q11 deletions in a schizophrenia population. Schizophr. Res. 2001;52:167–170
  2. Jacquet H, Raux G, Thibaut F, Hecketsweiler B, Houy E, Demilly C, et al. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Hum. Mol. Genet. 2002;11:2243–2249
  3. Karayiorgou M, Morris MA, Morrow B, Shprintzen RJ, Goldberg R, Borrow J, et al  Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc. Natl. Acad. Sci. U. S. A. 1995;92:7612–7616
  4. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, et al. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2002;99:3717–3722
  5. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch. Gen. Psychiatry. 1999;56:940–945
  6. Takahashi S, Ohtsuki T, Yu SY, Tanabe E, Yara K, Kamioka M, et al. Significant linkage to chromosome 22q for exploratory eye movement dysfunction in schizophrenia. Am. J. Med. Genet. 2003;120 B:11–17
  7. Usiskin SI, Nicolson R, Krasnewich DM, Yan W, Lenane M, Wudarsky M, et al. Velocardiofacial syndrome in childhood-onset schizophrenia. J. Am. Acad. Child. Adolesc. Psych. 1999;38:1536–1543
  8. Wilson DI, Cross IE, Wren C, Scambler PJ, Burn J, Goodship J. Minimum prevalence of chromosome 22q11 deletions. Am. J. Hum. Genet. 1994;55:A169

☆ This study was supported by the grant of Research on Brain Science and the grant for Nervous and Mental Disorders from the Ministry of Health, Labor and Welfare, and Grant-in-Aid for Scientific Research on Priority Areas “Medical Genome Science” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PII: S0920-9964(03)00160-9

doi: 10.1016/S0920-9964(03)00160-9

Schizophrenia Research
Volume 67, Issue 1 , Pages 111-113 , 1 March 2004

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