Schizophrenia Research
Volume 67, Issue 1 , Pages 71-74 , 1 March 2004

Differences in p53 gene polymorphisms between Korean schizophrenia and lung cancer patients

  • J.K. Park

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • These authors contributed equally to this work.
    • ,
  • H.J. Lee

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • These authors contributed equally to this work.
    • ,
  • J.W. Kim

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • ,
  • Y.H. Park

      Affiliations

    • Department of Medical Oncology, Korea Cancer Center Hospital, Seoul, South Korea
    • ,
  • S.S. Lee

      Affiliations

    • Department of Hemato Oncology, Kangbuk Samsung Hospital, Seoul, South Korea
    • ,
  • H.I. Chang

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • ,
  • J.Y. Song

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • ,
  • D.J. Yoon

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • ,
  • G.H. Bahn

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • ,
  • Y.H. Shin

      Affiliations

    • Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
    • ,
  • Y.J. Kim

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • ,
  • S.A. Kim

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • ,
  • B.K. Choe

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • ,
  • C.J. Kim

      Affiliations

    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
    • ,
  • J.H. Chung

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +82-2-961-0281; fax: +82-2-968-0560.
    • Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea

Received 28 October 2002 ,Accepted 18 May 2003.

References 

  1. Biros E, Kalina I, Kohut A, Stubna J, Salagovic J. Germ line polymorphisms of the tumor suppressor gene p53 and lung cancer. Lung Cancer. 2001;31:157–162
  2. Catts VS, Catts SV. Apoptosis and schizophrenia: is the tumor suppressor gene, p53, a candidate susceptibility gene?. Schizophr. Res. 2000;41:405–415
  3. Cohen ME, Dembling B, Schorling JB. The association between schizophrenia and cancer: a population-based mortality study. Schizophr. Res. 2002;57:139–146
  4. Freedman R, Leonard S, Olincy A, Kaufmann CA, Malaspina D, Cloninger CR, et al. Evidence for the multigenic inheritance of schizophrenia. Am. J. Med. Gen. 2001;105:794–800
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  7. Jablensky A, Lawrence D. Schizophrenia and cancer: is there a need to invoke a protective gene?. Arch. Gen. Psychiatry. 2001;58:579–580
  8. Kawajiri K, Nakachi K, Imai K, Watanabe J, Hayashi S. Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer. Carcinogenesis. 1993;14:1085–1089
  9. Lichtermann D, Ekelund J, Pukkala E, Tanskanen A, Lonnqvist J. Incidence of cancer among patients with schizophrenia and their relatives. Arch. Gen. Psychiatry. 2001;58:573–578
  10. Mortensen PB. The occurrence of cancer in first admitted schizophrenic patients. Schizophr. Res. 1994;12:185–194
  11. Sidransky D, Hollstein M. Clinical implication of the p53 gene. Annu. Rev. Med. 1996;47:285–301
  12. Sullivan PF, Eaves LJ, Kendler KS, Neale MC. Genetic case-control association studies in neuropsychiatry. Arch. Gen. Psychiatry. 2001;58:1015–1024
  13. Xie X, Ott J. Testing linkage disequilibrium between a disease gene and marker loci. Am. J. Hum. Genet. 1993;53:1107

PII: S0920-9964(03)00155-5

doi: 10.1016/S0920-9964(03)00155-5

Schizophrenia Research
Volume 67, Issue 1 , Pages 71-74 , 1 March 2004

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