Differences in p53 gene polymorphisms between Korean schizophrenia and lung cancer patients

Park, J.K.; Lee, H.J.; Kim, J.W.; Park, Y.H.; Lee, S.S.; Chang, H.I.; Song, J.Y.; Yoon, D.J.; Bahn, G.H.; Shin, Y.H.; Kim, Y.J.; Kim, S.A.; Choe, B.K.; Kim, C.J.; Chung, J.H.

doi:10.1016/S0920-9964(03)00155-5

« Previous Next »Schizophrenia Research
Volume 67, Issue 1 , Pages 71-74, 1 March 2004

Differences in p53 gene polymorphisms between Korean schizophrenia and lung cancer patients

J.K. Park
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
- These authors contributed equally to this work.
H.J. Lee
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
- These authors contributed equally to this work.
J.W. Kim
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
Y.H. Park
- Department of Medical Oncology, Korea Cancer Center Hospital, Seoul, South Korea
S.S. Lee
- Department of Hemato Oncology, Kangbuk Samsung Hospital, Seoul, South Korea
H.I. Chang
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
J.Y. Song
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
D.J. Yoon
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
G.H. Bahn
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
Y.H. Shin
- Department of Neuropsychiatry, Kyung Hee University Hospital, Seoul, South Korea
Y.J. Kim
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
S.A. Kim
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
B.K. Choe
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
C.J. Kim
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea
J.H. Chung
- Corresponding author. Tel.: +82-2-961-0281; fax: +82-2-968-0560.
- Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-Ku, Seoul 130-701, South Korea

Received 28 October 2002; accepted 18 May 2003.

Abstract

The reduced incidence of cancer observed in schizophrenia patients may be related to differences in genetic background. It has been suggested that genetic predisposition towards schizophrenia is associated with reduced vulnerability to lung cancer, and p53 gene is one of the candidate genes. We tested the genetic association between schizophrenia and lung cancer by analyzing polymorphic sites in the p53 gene. Genotype and allele frequencies at two polymorphic sites in the p53 gene (BstUI and MspI restriction sites in exon 4 and intron 6, respectively) were studied in Korean schizophrenia (n=179) and lung cancer patients (n=104). Comparisons of the genotype and allele frequencies of the MspI polymorphism revealed significant differences between schizophrenia and lung cancer patients. The results suggest that the p53 polymorphism specifically found in schizophrenia patients may be associated with reduced vulnerability to lung cancer.

Keywords: Schizophrenia, Lung cancer, p53 gene, Polymorphisms