Schizophrenia Research
Volume 67, Issue 1 , Pages 1-10 , 1 March 2004

Mismatch negativity in schizophrenia: a family study

  • Elvira Bramon

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +44-207-848-5036; fax: +44-207-701-9044.
    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • Rodney J Croft

      Affiliations

    • Department of Behavioural and Cognitive Sciences, Imperial College School of Medicine, St. Dunstan's Road, London W6 8RF, UK
    • ,
  • Colm McDonald

      Affiliations

    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • Gurkamal K Virdi

      Affiliations

    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • John G Gruzelier

      Affiliations

    • Department of Behavioural and Cognitive Sciences, Imperial College School of Medicine, St. Dunstan's Road, London W6 8RF, UK
    • ,
  • Torsten Baldeweg

      Affiliations

    • The Wolfson Centre, University College London and Great Ormond Street Hospital for Sick Children, Mecklenburgh Square, London WC1N 2AP, UK
    • ,
  • Pak C Sham

      Affiliations

    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • Sophia Frangou

      Affiliations

    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • Robin M Murray

      Affiliations

    • Institute of Psychiatry, P.O. Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK

Received 9 May 2002 ,Accepted 20 April 2003.

References 

  1. Alain C, Hargrave R, Woods D. Processing of auditory stimuli during visual attention in patients with schizophrenia. Biological Psychiatry. 1998;44:1151–1159
  2. Almasy L, Blangero J. Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. American Journal of Medical Genetics. 2001;105(1):42–44
  3. Annett M. A classification of hand preference by association analysis. British Journal of Psychology. 1970;61:303–321
  4. Barrett K, Fulfs J. Effect of gender on the mismatch negativity auditory evoked potential. Journal of the American Academy of Audiology. 1998;9(6):444–451
  5. Binder D. On the variances of asymptotically normal estimators from complex surveys. International Statistical Review. 1983;51:279–292
  6. Blackwood D. P300, a state and a trait marker in schizophrenia. The Lancet. 2000;355(4):771–772
  7. Blackwood DH, St. Clair DM, Muir WJ, Duffy JC. Auditory p300 and eye tracking dysfunction in schizophrenic pedigrees. Archives of General Psychiatry. 1991;48:899–909
  8. Breush T, Pagan A. The Lagrange multiplier test and its applications to model specification in econometrics. Review of Economic Studies. 1980;47:239–253
  9. Catts SV, Shelley AM, Ward PB, Liebert B, McConaghy N, Andrews S, et al. Brain potential evidence for an auditory sensory memory deficit in schizophrenia. American Journal of Psychiatry. 1995;152(2):213–219
  10. Clementz BA, Geyer MA, Braff DL. Poor p50 suppression among schizophrenia patients and their first-degree biological relatives. American Journal of Psychiatry. 1998;155(12):1691–1694
  11. Croft R, Barry R. Eog correction of blinks with saccade coefficients: a test and revision of the aligned-artefact average solution. Clinical Neurophysiology. 2000;11:444–541
  12. De Geus EJ. Introducing genetic psychophysiology. Biological Psychology. 2002;61(1–2):1–10
  13. DeLisi LE, Goldin LR, Hamovit JR, Maxwell ME, Kurtz D, Gershon ES. A family study of the association of increased ventricular size with schizophrenia. Archives of General Psychiatry. 1986;43(2):148–153
  14. Faraone SV, Kremen WS, Seidman LJ, Peple JR, Lyons MJ, Tsuang MT. Neuropsychology in relatives of schizophrenics. In: Annual Meeting of the American Psychiatric Association. May. 1992;
  15. Frangou S, Sharma T, Alarcon G, Sigmudsson T, Takei N, Binnie C, et al. The Maudsley family study, ii: endogenous event-related potentials in familial schizophrenia. Schizophrenia Research. 1997;23:45–53
  16. Freedman R, Adler LE, Leonard S. Alternative phenotypes for the complex genetics of schizophrenia. Biological Psychiatry. 1999;45:551–558
  17. Garver D. Methodological issues facing the interpretation of high-risk studies: biological heterogeneity. Schizophrenia Bulletin. 1987;13(3):525–529
  18. Hirayasu Y, Asato N, Ohta H, Hokama H, Arakaki H, Ogura C. Abnormalities of auditory event-related potentials in schizophrenia prior to treatment. Biological Psychiatry. 1998;43:244–253
  19. Iacono WG, Moreau M, Beser M, Fleming JAE, Lin TY. Smooth pursuit eye tracking in first episode psychotic patients and their relatives. Journal of Abnormal Psychology. 1992;101:104–116
  20. Jasper H. Report to the committee on methods of clinical examination in electroencephalography. Electroencephalography and Clinical Neurophysiology. 1958;10:371–375
  21. Javitt D, Doneshka P, Zylberman I, Ritter W, Vaughan HJ. Impairment of early cortical processing in schizophrenia: an event-related potential confirmation study. Biological Psychiatry. 1993;33:513–519
  22. Javitt DC, Doneshka P, Grochowski S, Ritter W. Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Archives of General Psychiatry. 1995;52:550–558
  23. Javitt D, Steinschneider M, Schroeder C, Arezzo J. Role of cortical N-methyl-d-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. Procedures of the National Academy of Science. 1996;93:11962–11967
  24. Javitt D, Shelley A, Silipo G, Lieberman J. Deficits in auditory and visual context-dependent processing in schizophrenia. Archives of General Psychiatry. 2000;57:1131–1137
  25. Jessen F, Fries T, Kucharski C, Nishimura T, Hoenig K, Maier W, et al. Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia. Neuroscience Letters. 2001;309(3):185–188
  26. Kathmann N, Wagner M, Rentsorff N, Engel R. Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics. Biological Psychiatry. 1995;37:754–757
  27. Kay S, Fiszbein A, Opler L. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  28. In:  Kendler K editors. The genetics of schizophrenia and related disorders: a review. New York: Raven Press; 1988;
  29. Kendler KS, Diehl SR. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophrenia Bulletin. 1993;19(2):261–285
  30. Kirino E, Inoue R. The relationship of mismatch negativity to quantitative eeg and morphological findings in schizophrenia. Journal of Psychiatric Research. 1999;33:445–456
  31. Maxwell M. Family Interview for Genetic Studies, Clinical Neurogenetics Branch, Intramural Research Program. National Institute of Mental Health; 1992;
  32. Michie PT. What has MMN revealed about the auditory system in schizophrenia?. International Journal of Psychophysiology. 2001;42(2):177–194
  33. Michie P, Budd T, Todd J, Rock D, Wichmann H, Box J, et al. Duration and frequency mismatch negativity in schizophrenia. Clinical Neurophysiology. 2000;111:1054–1065
  34. Michie PT, Innes-Brown H, Todd J, Jablensky A. Duration of mmn in first-degree relatives of patients with schizophrenia spectrum disorders. Schizophrenia Research. 2002;53(3):19
  35. Naatanen R, Picton T. The n1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. Psychophysiology. 1987;42:313–329
  36. Naatanen R, Paavilainen P, Alho K, Reinikainen K, Sams M. Do event-related potentials reveal the mechanism of the auditory sensory memory in the human brain?. Neuroscience Letters. 1989;98:217–221
  37. Oades R, Dittmann-Balcar A, Zerbin D, Grzella I. Impaired attention-dependent augmentation of mmn in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive–compulsive disorder and healthy subjects. Biological Psychiatry. 1997;41:1196–1210
  38. O'Donnell B, Hokama H, McCarley R, Smith R, Salisbury D, Mondrow E, et al. Auditory erps to non-target stimuli in schizophrenia: relationship to probability, task demands, and target erps. International Journal of Psychophysiology. 1994;17:219–231
  39. Olney J, Farber N. Glutamate receptor dysfunction and schizophrenia. Archives of General Psychiatry. 1995;52(12):998–1007
  40. Rieder R, Gershon E. Genetic strategies in biological psychiatry. Archives of General Psychiatry. 1978;35(7):866–873
  41. Sams M, Kaukoranta E, Hamalainen M. Cortical activity elicited by changes in auditory stimuli: different sources for the magnetic n100m and mismatch responses. Psychophysiology. 1991;28:21–29
  42. Scherg M, Vasjar J, Picton T. A source analysis of the late human auditory evoked potentials. Journal of Cognitive Neuroscience. 1989;1:336–355
  43. Sham PC, Morton NE, Muir WJ, Walker M, Collins A, Shields DC, et al. Segregation analysis of complex phenotypes: an application to schizophrenia and auditory p300 latency. Psychiatric Genetics. 1994;4:29–38
  44. Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, et al. Brain changes in schizophrenia. Volumetric mri study of families multiply affected with schizophrenia—the Maudsley family study 5. British Journal of Psychiatry. 1998;173:132–138
  45. Sharma T, Lancaster E, Sigmundsson T, Lewis S, Takei N, Gurling H, et al. Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives–the Maudsley family study. Schizophrenia Research. 1999;40(2):111–120
  46. Shelley AM, Ward PB, Catts SV, Michie PT, Andrews S, McConaghy N. Mismatch negativity: an index of preattentive processing deficit in schizophrenia. Biological Psychiatry. 1991;30:1059–1062
  47. Shelley A, Silipo G, Javitt D. Diminished responsiveness of erps in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction. Schizophrenia Research. 1999;37:65–79
  48. Spitzer, R., Endicott, J., 1978. Schedule for affective disorders and schizophrenia.
  49. Tiitinen H, May P, Reinikainen K, Naatanen R. Attentive novelty detection in humans ins governed by pre-attentive sensory memory. Nature. 1994;372:90–92
  50. Todd J, Michie PT. Do perceived loudness cues contribute to duration mismatch negativity (MMN)?. Neuroreport. 2000;11(17):3771–3774
  51. Tsuang M, Stone W, Faraone S. Toward reformulating the diagnosis of schizophrenia. American Journal of Psychiatry. 2000;157(7):1041–1050
  52. Umbricht D, Schmid L, Koller R, Vollenweider F, Hell D, Javitt D. Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers. Archives of General Psychiatry. 2000;57:1139–1147
  53. Wickham H, Murray RM. Can biological markers identify endophenotypes predisposing to schizophrenia?. International Review of Psychiatry. 1997;9:355–364
  54. Wickham H, Walsh C, Asherson P, Taylor C, Sigmundson T, Gill M, et al. Familiality of symptom dimensions in schizophrenia. Schizophrenia Research. 2001;47(2–3):223–232

PII: S0920-9964(03)00132-4

doi: 10.1016/S0920-9964(03)00132-4

Schizophrenia Research
Volume 67, Issue 1 , Pages 1-10 , 1 March 2004

Article Tools

* Image Usage & Resolution