Schizophrenia Research
Volume 66, Issue 1 , Pages 41-49 , 1 January 2004

Gender and the use of neuroleptics in schizophrenia

  • raimo k.r. salokangas

      Affiliations

    • Corresponding Author InformationDepartment of Psychiatry, University of Turku, Turku, Finland. Tel.: +358-2-3131-740; fax: +358-2-3132-730.

Received 27 May 2002 ,Accepted 13 December 2002.

References 

  1. Abe T, Yama Y, Wada Y, Suzuki M. Pituitary–ovarian relationships in women approaching the menopause. Maturitas. 1983;5:31–37
  2. Alanen YO, Räkköläinen V, Laakso J, Rasimus R, Kaljonen A. Towards Need-Spesific Treatment of Schizophrenic Psychoses. Heidelberg: Springer-Verlag; 1986;
  3. Angermeyer MC, Kühn L. Gender differences in age at onset of schizophrenia. An overview. Eur. Arch. Psychiatry Neurol. Sci. 1988;237:351–364
  4. Angermeyer MC, Goldstein JM, Kuehn L. Gender differences in schizophrenia: rehospitalization and community survival. Psychol. Med. 1989;19:365–382
  5. Bland RC, Orn H. 14-Year outcome in early schizophrenia. Acta Psychiatr. Scand. 1978;58:327–338
  6. Brenner PF. The menopause. West. J. Med. 1982;136:211–219
  7. Carpenter WT, Heinrichs DW, Wagman AMI. Deficit and nondeficit forms of schizophrenia: the concept. Am. J. Psychiatry. 1988;145:578–583
  8. Davidson JM, Chen JJ, Crapo L, Graym GD, Greenleafm WJ, Cataniam JA. Hormonal changes and sexual function in aging men. J. Clin. Endocr. Metab. 1983;57:71–77
  9. Endicott J, Spitzer RL, Fleis JL, Cohen J. The Global Assessment Scale. A procedure for measuring overall severity of psychiatric disturbance. Arch. Gen. Psychiatry. 1976;33:766–771
  10. Farina A. Are women nicer people then men? Sex and the stigma of mental disorders. Clin. Psychol. Rev. 1981;1:223–243
  11. Häfner H, Riecher A, Mauer K, Löffler W, Munk-Jörgensen P, Strömgren E. How does gender influence age at first hospitalization for schizophrenia? A transnational case register study. Psychol. Med. 1989;19:903–918
  12. Häfner H, Behrens S, De-Vry J, Gattaz WF. Öestradiol enhances the vulnerability threshold for schizophrenia in women by early effect on dopaminergic neurotransmission. Evidence from an epidemiological study and from animal experiments. Eur. Arch. Psychiatry Clin. Neurosci. 1991;241:65–68
  13. Haring C, Meise U, Humpel C, Saria A, Fleischhacker WW, Hinterhuber H. Dose-related plasma levels of clozapine: influence of smoking behavior, sex, and age. Psychopharmacology. 1989;99:S38–S40
  14. Herran A, de-Santiago A, Sandoya M, Fernandez MJ, Diez-Manrique JF, Vazquez-Barquero JL. Determinants of smoking behaviour in outpatients with schizophrenia. Schizophr. Res. 2000;41:373–381
  15. Honkonen T, Saarinen S, Salokangas RKR. Deinstitutionalization and schizophrenia in Finland II: discharged patients and their psychosocial functioning. Schizophr. Bull. 1999;25:547–555
  16. Hughes JR, Hatsukami DK, Mitchell JE, Dahlgren LA. Prevalence of smoking among psychiatric outpatients. Am. J. Psychiatry. 1986;143:993–997
  17. Inoue M, Suhara T, Sudo Y, Okubo Y, Yasuno F, Kishimoto T, et al. Age-related reduction of extrastriatal dopamine D2 receptor measured by PET. Life Sci. 2001;69:1079–1084
  18. Jann M, Saklad SR, Ereshefsky L, Richards AL, Harington CA, Davis CM. Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance. Psychopharmacology. 1986;90:468–470
  19. Kaasinen V, Vilkman H, Hietala J, Nagren K, Helenius H, Olsson H, et al. Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol. Aging. 2000;21:683–688
  20. Kaneda Y, Fujii A. Effects of chronic neuroleptic admisnistration on the hypothalamo–pituarity–gonadal axis of male schizophrenics. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2000;24:251–258
  21. Krailo MD, Pike MC. Estimation of the distribution of age at natural menopause from prevalence data. Am. J. Epidemiol. 1983;117:356–361
  22. Krakowski M, Volavka J, Brizer D. Psychopathology and violence: a review of literature. Compr. Psychiat. 1986;27:131–148
  23. Lohr JB, Flynn K. Smoking and schizophrenia. Schizophr. Res. 1992;8:93–102
  24. Longcope C, Franz C, Morello C, Baker R, Johnston CC. Steroid and gonadotropin levels in women during the peri-menopausal years. Maturitas. 1988;10:189–198
  25. Lääkintöhallitus, 1986. Tautiluokitus 1987. (Classification of diseases 1987.) Helsinki: Valtion painatuskeskus.
  26. McGuire MT, Troisi A. Aggression. In:  Kaplan HI,  Sadock BJ editor. Comprehensive Textbook of Psychiatry. 5th ed.. Baltimore: Williams and Wilkins; 1989;p. 271–282
  27. Miller RR. Effects of smoking on drug action. Clin. Pharmacol. Ther. 1977;22:749–756
  28. Mozley LH, Gur RC, Mozley D, Gur RE. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am. J. Psychiatry. 2001;158:1492–1499
  29. Murphy DGM, DeCarli C, McIntosh AR, Daly E, Mentis JM, Pietrini P, et al. Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on effect of aging. Arch. Gen. Psychiatry. 1996;53:585–594
  30. Räsänen P, Hakko H, Visuri S, Paanila J, Kapanen P, Suomela T, et al. Serum testosterone levels, mental disorders and criminal behaviour. Acta Psychiatr. Scand. 1999;99:346–352
  31. Riecher-Rössler A, Häfner H. Schizophrenia and oestrogens—is there an association?. Eur. Arch. Psychiatry Clin. Neurosci. 1993;242:223–328
  32. Salokangas RKR. Psychosocial prognosis in schizophrenia. Formation of the prognosis for schizophrenic patients: a multivariate analysis. Turku: Annales Universitatis Turkuensis ser D 9; 1978;
  33. Salokangas RKR. Prognostic implications of the sex of schizophrenic patients. Br. J. Psychiatry. 1983;142:145–151
  34. Salokangas RKR. Gender and the use of neuroleptics in schizophrenia. Further testing of the oestrogen hypothesis. Schizophr. Res. 1995;16:7–16
  35. Salokangas RKR, Saarinen S. Deinstitutionalisation and schizophrenia in Finland: discharged patients and their care. A follow-up study of schizophrenic patients discharged from Finnish mental hospitals in 1982, 1986 and 1990. Schizophr. Bull. 1998;24:457–467
  36. Salokangas RKR, Stengård E. Gender and short-term outcome in schizophrenia. Schizophr. Res. 1990;3:333–345
  37. Salokangas RKR, Saarijärvi S, Taiminen T, Lehto H, Niemi H, Ahola V, et al. Effect of smoking on neuroleptics in schizophrenia. Schizophr. Res. 1997;23:55–60
  38. Salokangas, R.K.R., Stengård, E., Honkonen, T., Koivisto, A.-M., Saarinen, S., 2000. Sairaalasta yhteiskuntaan. (From Hospital to the Community; Finnish report). STAKES, Raportteja 248, Helsinki.
  39. Salokangas RKR, Honkonen T, Stengård E. Discharged schizophrenia patients in the community—implications for service development. A follow-up study of schizophrenia patients discharged from Finnish mental hospitals in 1982, 1986, 1990 and 1994. Psychiatria Fennica Suppl. 2001;2:111–122
  40. Sartorius N, Jablensky A, Korten A, Ernberg G, Anker M, Cooper JE, et al. Early manifestations and first-contact incidence of schizophrenia in different cultures. Psychol. Med. 1986;16:909–928
  41. Schlosser R, Brodie JD, Dewey S-L, Alexoff D, Wang GJ, Fowler JS, et al. Long-term stability of neurotransmitter activity investigated with 11C-raclopride PET. Synapse. 1998;28:66–70
  42. Seeman MV. Interaction of sex, age, and neuroleptic dose. Compr. Psychiatry. 1983;24:125–128
  43. Seeman MV. Current outcome in schizophrenia: women vs men. Acta Psychiatr. Scand. 1986;73:609–617
  44. Seeman MV, Lang M. The role of estrogens in schizophrenia gender differences. Schizophr. Bull. 1990;16:185–194
  45. Shepherd M, Watt D, Falloon I, Smeeton N. The natural history of schizophrenia: a five year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychol. Med. Monogr. Suppl. 1989;15:
  46. Sherman BM, Korenman SG. Hormonal characteristics of the human menstrual cycle throughout reproductive life. J. Clin. Invest. 1975;55:699–706
  47. Stearns EL, MacDonnel JA, Kaufman BJ, Padua R, Lucman TS, Winter JSD, et al. Declining testicular function with age. Am. J. Med. 1974;57:761–766
  48. Wattie BJS, Kedward HB. Gender differences in living conditions found among male and female schizophrenic patients on a follow-up study. Int. J. Soc. Psychiatry. 1985;31:205–216
  49. Virkkunen M, Rawlings R, Tokola R, Poland R, Guidotti A, Nemeroff C, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch. Gen. Psychiatry. 1994;51:20–27
  50. Wyatt RJ. Biochemistry and Schizophrenia (Part IV). The neuroleptics— their mechanism of action: a review of the biochemical literature. Psychopharmacol. Bull. 1976;12:5–55
  51. Ziedonis DM, Kosten TR, Glazer WM, Frances RJ. Nicotine dependence and schizophrenia. Hosp. Com. Psychiatry. 1994;45:204–206

PII: S0920-9964(02)00530-3

doi: 10.1016/S0920-9964(02)00530-3

Schizophrenia Research
Volume 66, Issue 1 , Pages 41-49 , 1 January 2004

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