Schizophrenia Research
Volume 62, Issue 1 , Pages 123-131 , 1 July 2003

Ventricular enlargement in schizophrenia: a primary change in the temporal lobe?

Received 15 November 2001 ,Accepted 21 June 2002.

References 

  1. Andreasen N, Smith M, Jacoby C, Dennert J, Olsen S. Ventricular enlargement in schizophrenia. Definition and prevalence. Am. J. Psychiatry. 1982;139
  2. Bartzokis G, Nuechterlein K, Marder S, Mintz J, Dery K, Laack K. Age at illness onset and left temporal lobe length in males with schizophrenia. Psychiatry Res. Neuroimaging. 1996;67:189–201
  3. Bear DM, Schiff D, Saver J, et al.  Quantitative analysis of cerebral asymmetry; fronto-occipital correlation, sexual dimorphism and association with handedness. Arch. Neurol. 1986;43:598–603
  4. Blamire A, Rowe J, Sykes P, McDonald B. Postmortem brain MRI: preliminary studies to optimize grey-white matter contrast, leading to assessment of structural and symmetry changes in schizophrenia. Schizophr. Res. 1996;18:181–182
  5. Bogerts B, Meerts E, Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage. Arch. Gen. Psychiatry. 1985;42:784–791
  6. Bogerts B, Ashtari M, Degreef G, Alvir JM, Bilder RM, Lieberman JA. Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res. Neuroimaging. 1990;35:1–13
  7. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, et al.  Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch. Gen. Psychiatry. 1986;43:36–42
  8. Bruton CJ, Crow TJ, Frith CD, Johnstone EC, Owens DG, Roberts GW. Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychol. Med. 1990;20:285–304
  9. Buchsbaum MS, Yang S, Hazlett E, Siegel BV, Germans M, Haznedar M, et al.  Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging. Schizophr. Res. 1997;27(1):45–53 Oct 17
  10. Cannon TD, van Erp TG, Huttunen M, Lonnqvist J, Salonen O, Valanne L, et al. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch. Gen. Psychiatry. 1998;55(12):1084–1091
  11. Chance SA, Esiri MM, Crow TJ. Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findings. Br. J. Psychiatry. 2002;180:331–338
  12. Crow TJ, Crow LR. Temporal lobe length reductions in schizophrenia—a post-mortem photographic study of unfixed brain from the Runwell 3 series. Schizophr. Res. 1996;18:179–180
  13. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, et al.  Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. Arch. Gen. Psychiatry. 1989;46:1145–1150
  14. Dauphinais ID, DeLisi LE, Crow TJ, Alexandropoulos K, Colter N, Tuma I, et al. Reduction in temporal lobe size in siblings with schizophrenia: a magnetic resonance imaging study. Psychiatry Res. 1990;35:137–147
  15. Degreef G, Ashtari M, Bogerts B, Bilder RM, Jody DN, Alvir JMJ, et al. Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch. Gen. Psychiatry. 1992;49:531–537
  16. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, et al.  Brain morphology in first episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol. Psychiatry. 1991;29:159–175
  17. Giedd JN, Snell JW, Lange N, Rajapakse JC, Casey BJ, Kozuch PL, et al.  Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb. Cortex. 1996;6:551–560
  18. Gur R, Mozley P, Shtasel D, Cannon T, Gallacher F, Turetsky B, et al.  Clinical subtypes of schizophrenia: differences in brain and CSF volume. Am. J. Psychiatry. 1994;151:343–350
  19. Harvey I, Williams M, Toone R, Lewis S, McGuffin P. The ventricle-brain ratio (VBR) in functional psychoses; the relationship of lateral ventricular and total ventricular area. Psychol. Med. 1990;20:55–62
  20. Haug JO. Pneumoencephalographic studies in mental disease. Acta Psychiatr. Scand. 1962;38(Suppl. 165):11–104
  21. Highley JR, Esiri MM, McDonald B, Cortina-Borja M, Cooper S, Herron B, et al. Temporal lobe length is reduced, and gyral folding is increased in schizophrenia: a postmortem study. Schizophr. Res. 1998;34:1–12
  22. Highley JR, Esiri MM, McDonald B, Cortina-Borja M, Cooper S, Herron B, et al. Anomalies of cerebral asymmetry in schizophrenia interact with gender and age of onset: a post-mortem study. Schizophr. Res. 1998;34:13–25
  23. Highley JR, McDonald B, Walker MA, Esiri MM, Crow TJ. Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume. Br. J. Psychiatry. 1999;175:127–134
  24. Highley JR, Walker MA, Esiri MM, McDonald B, Harrison PJ, Crow TJ. Schizophrenia and the frontal lobes. Postmortem stereological study of tissue volume. Br. J. Psychiatry. 2001;178:337–343
  25. Hunter R, Jones M, Cooper F. Modified lumbar air encephalography in the investigation of long stay psychiatric patients. J. Neurol. Sci. 1968;6:593–596
  26. James A, Crow TJ, Renowden S, Wardell AM, Smith DM, Anslow P. Is the course of brain development in schizophrenia delayed?—Evidence from onsets in adolescence. Schizophr. Res. 1999;40:1–10
  27. Kawasaki Y, Maeda Y, Urata K, Higashima M, Yamaguchi N, Suzuki M, et al.  A quantitative magnetic resonance imaging study of patients with schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 1993;242:268–272
  28. Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br. J. Psychiatry. 1998;172:110–120
  29. Lawrie SM, Whalley H, Kestelman JN, Abukmeil SS, Byrne M, Hodges A, et al. Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet. 1999;353(9146):30–33 [see comments]
  30. Marais, P., 1998. The segmentation of sparse MR Images, D.Phil thesis. University of Oxford.
  31. Mathalon D, Sullivan E, Rawles J, Pfefferbaum A. Correction for head size in brain-imaging measurements. Psychiatry Res. 1993;50
  32. McCarley R, Wible C, Frumin M, Hirayasu Y, Levitt J, Fischer I, et al. MRI anatomy of schizophrenia. Biol. Psychiatry. 1999;45:1099–1119
  33. McDonald B, Highley JR, Walker MA, Herron BM, Cooper SJ, Esiri MM, et al. Anomalous asymmetry of fusiform and parahippocampal gyrus grey matter in schizophrenia: a post-mortem study. Am. J. Psychiatry. 2000;157:40–47
  34. Narr KL, Thompson PM, Sharma T, Moussai J, Blanton R, Anvar B, et al. Three-dimensional mapping of temporo-limbic regions and the lateral ventricles in schizophrenia: gender effects. Biol. Psychiatry. 2001;50(2):84–97 Jul 15
  35. Nasrallah HA, Schwarzkopf SB, Olson SC, Coffman JA. Gender differences in schizophrenia on MRI brain scans. Schizophr. Bull. 1990;16(2):205–210
  36. Nopoulos P, Flaum P, Andreasen NC. Sex differences in brain morphology in schizophrenia. Am. J. Psychiatry. 1997;154:1648–1654
  37. Quester R, Schroder R. The shrinkage of the human brain stem during formalin fixation and embedding in paraffin. J. Neurosci. Methods. 1997;75:81–89
  38. Reveley AM, Reveley MA, Clifford CA, Murray RM. Cerebral ventricular size in twins discordant for schizophrenia. Lancet. 1982;1(8271):540–541
  39. Roberts GW, Colter N, Lofthouse R, et al.  Is there gliosis in schizophrenia? Investigation of the temporal lobe. Biol. Psychiatry. 1987;22:1459–1468
  40. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, et al.  Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch. Gen. Psychiatry. 2000;57(5):471–480
  41. Shenton ME, Kikinis R, Jolesz F, Pollak SD, LeMay M, Wible CG, et al.  Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N. Engl. J. Med. 1992;327:604–612
  42. Silverman JM, Smith CJ, Guo SL, Mohs RC, Siever LJ, Davis KL. Lateral ventricular enlargement in schizophrenic probands and their siblings with schizophrenia-related disorders. Biol. Psychiatry. 1998;43(2):97–106
  43. Suddath RI, Casanova MF, Goldberg TE, Daniel DG, Kelsoe JR, Weinberger DR, et al.  Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. Am. J. Psychiatry. 1989;146:464–472
  44. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia [published erratum appears in N. Engl. J. Med. 1990 May 31;322(22):1616] [see comments]. N. Engl. J. Med. 1990;322(12):789–794
  45. Vita A, Dieci M, Silenzi C, Tenconi F, Giobbio GM, Invernizzi G. Cerebral ventricular enlargement as a generalized feature of schizophrenia: a distribution analysis on 502 subjects. Schizophr. Res. 2000;44:25–34
  46. Weinberger DR. Implications of normal brain developments for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 1987;44:660–669
  47. Wright IC, Rabe-Hesketh S, Woodruff PWR, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry. 2000;157:16–25

PII: S0920-9964(02)00344-4

doi: 10.1016/S0920-9964(02)00344-4

Schizophrenia Research
Volume 62, Issue 1 , Pages 123-131 , 1 July 2003

Article Tools

* Image Usage & Resolution