Schizophrenia Research
Volume 63, Issue 3 , Pages 261-271 , 1 October 2003

Episodic memory in schizophrenic patients and their relatives

  • T Toulopoulou

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +44-207-848-0061; fax: +44-207-701-9044
    • Division of Psychological Medicine [Box 63], Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
  • ,
  • S Rabe-Hesketh

      Affiliations

    • Department of Biostatistics and Computing, Institute of Psychiatry, London, UK
  • ,
  • H King

      Affiliations

    • Division of Psychological Medicine [Box 63], Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
  • ,
  • R.M Murray

      Affiliations

    • Division of Psychological Medicine [Box 63], Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
  • ,
  • R.G Morris

      Affiliations

    • Department of Psychology, Institute of Psychiatry, London, UK

Received 13 June 2001 ,Accepted 27 May 2002.

References 

  1. Albus M, Hubmann W, Ehrenberg Ch, Forcht U, Mohr F, Sobizack N, et al. Neuropsychological impairment in first-episode and chronic schizophrenic patients. Eur. Arch. Psychiatry Clin. Neurosci. 1996;246:249–255
  2. Aleman A, Hijman R, de Haan EHF, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry. 1999;15:1358–1366
  3. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 3rd edn.. Washington, DC: American Psychiatric Association; 1987;
  4. Baron M, Asnis L, Gruen R. The schedule for schizotypal personalities (SSP): a diagnostic interview for schizotypal features. Psychiatry Res. 1981;4:213–228
  5. Beatty WW, Jocic Z, Monson N, Staton RD. Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder. J. Nerv. Ment. Dis. 1993;81:448–453
  6. Binder J, Albus M, Hubmann W, Scherer J, Sobizack N, Franz U, et al. Neuropsychological impairment and psychopathology in first-episode schizophrenic patients related to the early course of illness. Eur. Arch. Psychiatry Clin. Neurosci. 1998;248:70–77
  7. Byrne M, Hodges A, Grant E, Owens DC, Johnstone EC. Neuropsychological assessment of young people at high genetic risk for developing schizophrenia compared with controls: preliminary findings of the Edinburgh High Risk Study (EHRS). Psychol. Med. 1999;29:1161–1173
  8. Byrne M, Cosway R, Hodges A, Grant E, Clafferty B, Cunningham Owens D, et al. Neuropsychological assessment in the Edinburgh high risk for schizophrenia study. Schizophr. Res. 2000;41:271
  9. Canavan AGM, Dunn G, McMillan TM. Principal components of the WAIS-R. Br. J. Clin. Psychol. 1986;25:81–85
  10. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch. Gen. Psychiatry. 1994;51:651–661
  11. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, et al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am. J. Hum. Genet. 2000;67:369–382
  12. Cornblatt B, Obuchowski M. Update of high-risk research: 1987–1997. Int. Rev. Psychiatry. 1997;9:437–447
  13. Duffy L, O'Carroll R. Memory impairment in schizophrenia—a comparison with that observed in the Alcoholic Korsakoff Syndrome. Psychol. Med. 1994;24:155–165
  14. Endicott J, Spitzer R. A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch. Gen. Psychiatry. 1978;35:837–844
  15. Endicott J, Andreasen NC, Spitzer RL. Family History Research Diagnostic Criteria. New York: New York State Psychiatric Institute, Biometrics Research Division; 1975;
  16. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J. Abnorm. Psychol. 1995;104:286–304
  17. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J. Abnorm. Psychol. 1999;108:176–181
  18. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol. Psychiatry. 2000;48:120–126
  19. Frangou S, Sharma T, Alarcon G, Sigmudsson T, Takei N, Binnie C, et al. The Maudsley Family Study: II. Endogenous event-related potentials in familial schizophrenia. Schizophr. Res. 1997;23:45–53
  20. Goldberg TE, Ragland JD, Torrey EF, Gold JM, Bigelow LB, Weinberger DR. Neuropsychological assessment of monozygotic twins discordant for schizophrenia. Arch. Gen. Psychiatry. 1990;47:1066–1072
  21. Goldberg TE, Torrey EF, Gold JM, Ragland JD, Bigelow LB, Weinberger DR. Learning and memory in monozygotic twins discordant for schizophrenia. Psychol. Med. 1993;23:71–85
  22. Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, et al. Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr. Res. 1995;17:77–84
  23. Goldstein LH, Polkey CE. Short-term cognitive changes after unilateral temporal lobectomy or unilateral amygdalo–hippocampectomy for the relief of temporal lobe epilepsy. J. Neurol. Neurosurg. Psychiatry. 1993;56:135–140
  24. Goldstein LH, Canavan AGM, Polkey CE. Verbal and abstract designs paired associate learning after unilateral temporal lobectomy. Cortex. 1988;24:41–52
  25. Griffiths TD, Sigmundsson T, Takei N, Frangou S, Birkett PB, Sharma T, et al. Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley Family Study. J. Neurol. Neurosurg. Psychiatry. 1998;64:56–60
  26. Gruzelier J, Seymour K, Wilson L, Jolley A, Hirsch S. Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Arch. Gen. Psychiatry. 1988;45:623–629
  27. Gruzelier JH, Wilson L, Liddiard D, Peters E, Pusavat L. Cognitive asymmetry patterns in schizophrenia: active and withdrawn syndromes and sex differences as moderators. Schizophr. Bull. 1999;25:349–362
  28. Gur RC, Ragland JD, Gur RE. Cognitive changes in schizophrenia—a critical look. Int. Rev. Psychiatry. 1997;9:449–457
  29. Harris JG, Adler LE, Young DA, Cullum CM, Rilling LM, Cicerello A, et al. Neuropsychological dysfunction in parents of schizophrenics. Schizophr. Res. 1996;20:253–260
  30. Heaton R, Paulsen JS, McAdams LA, Kuck J, Zisook S, Braff D, et al. Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia. Arch. Gen. Psychiatry. 1994;51:469–476
  31. Hoff AL, Riordan H, O'Donnell DW, DeLisi LE. Cross-sectional and longitudinal neuropsychological test findings in first episode schizophrenic patients. Schizophr. Res. 1991;5:197–198
  32. Huppert FA, Piercy M. Dissociation between learning and remembering in organic amnesia. Nature. 1978;275:317–318
  33. Krabbendam L, Marcelis M, Delespaul P, Jolles J, van Os J. Single or multiple familial cognitive risk factors in schizophrenia?. Am. J. Med. Genet. [Neuropsych. Genet.]. 2001;105:183–188
  34. Kremen WS, Seidman LJ, Pepple JR, Lyons MJ, Tsuang MT, Faraone SV. Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr. Bull. 1994;20:103–119
  35. Kremen WS, Goldstein JM, Seidman LJ, Toomey R, Lyons MJ, Tsuang MT, et al. Sex differences in neuropsychological function in non-psychotic relatives of schizophrenic probands. Psychiatry Res. 1997;66:131–144
  36. Kremen WS, Faraone SV, Seidman LJ, Pepple JR, Tsuang MT. Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands. Psychiatry Res. 1998;79:227–240
  37. Landrø NI. Memory function in schizophrenia. Acta Psychiatr. Scand. Suppl. 1994;90(384):87–94
  38. Laurent A, Moreaud O, Bosson JL, Naëgelé B, Boucharlat J, Saoud M, et al. Neuropsychological functioning among non-psychotic siblings and parents of schizophrenic patients. Psychiatry Res. 1999;87:147–157
  39. Loftus EF. Evaluating forgetting curves. J. Exp. Psychol. [Learn. Mem. Cogn.]. 1985;11:397–406
  40. Lyons MJ, Toomey R, Seidman LJ, Kremen WS, Faraone SV, Tsuang MT. Verbal learning and memory in relatives of schizophrenics: preliminary findings. Biol. Psychiatry. 1995;37:750–753
  41. McKenna P, Tamlyn D, Lund C, Mortimer A, Hammond S, Baddeley A. Amnesic syndrome in schizophrenia. Psychol. Med. 1990;20:967–972
  42. Mockler D, Riordan J, Sharma T. Memory and intellectual deficits do not decline with age in schizophrenia. Schizophr. Res. 1997;26:1–7
  43. Nopoulos P, Flashman L, Flaum M, Arndt S, Andreasen N. Stability of cognitive functioning early in the course of schizophrenia. Schizophr. Res. 1994;14:29–37
  44. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry. 1994;51:849–859
  45. Rabe-Hesketh S, Toulopoulou T, Murray R. Multilevel modelling of cognitive function in schizophrenic patients and their first degree relatives. Multivar. Behav. Res. 2001;36:279–298
  46. Rushe TM, Woodruff PWR, Murray RM, Morris RG. Episodic memory and learning in patients with chronic schizophrenia. Schizophr. Res. 1999;35:85–96
  47. Russell EW. A multiple scoring method for the assessment of complex memory functions. J. Consult. Clin. Psychol. 1975;43:800–809
  48. Saykin AJ, Gur RC, Gur RE, Mozley PD, Mozley LH, Resnick SM, et al. Neuropsychological function in schizophrenia. Selective impairment in memory and learning. Arch. Gen. Psychiatry. 1991;48:618–624
  49. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, et al. Neuropsychological deficits in neuroleptic naive patients with first episode schizophrenia. Arch. Gen. Psychiatry. 1994;51:124–131
  50. Shedlack K, Lee G, Sakuma M, Xie SH, Kushner M, Pepple J, et al. Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr. Res. 1997;25:43–52
  51. Stata Corporation 1984–1997. Stata Statistical Software: Release 5.0.
  52. Stirling JD, Hellewell JSE, Hewitt J. Verbal memory impairment in schizophrenia: no sparing of short-term recall. Schizophr. Res. 1997;25:85–95
  53. Tamlyn D, McKenna PJ, Mortimer AM, Lund CE, Hammond S, Baddeley AD. Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychol. Med. 1992;22:101–115
  54. Toomey R, Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Tsuang MT. Association of neuropsychological vulnerability markers in relatives of schizophrenic patients. Schizophr Res. 1998;31:89–98
  55. Wechsler D. A standardised memory scale for clinical use. J. Psychol. 1945;19:87–95
  56. Wechsler D. Wechsler Adult Intelligence Scale—Revised Manual. New York: Psychological Corporation; 1981;

PII: S0920-9964(02)00324-9

doi: 10.1016/S0920-9964(02)00324-9

Schizophrenia Research
Volume 63, Issue 3 , Pages 261-271 , 1 October 2003