Schizophrenia Research
Volume 58, Issue 1 , Pages 37-41 , 1 November 2002

Association analysis of polymorphic CGG repeat in 5′ UTR of the reelin and VLDLR genes with schizophrenia

Received 16 October 2001 ,Accepted 18 November 2001.

References 

  1. Bayer TA, Falkai P, Maier W. Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “two hit hypothesis”. J. Psychiatr. Res. 1999;33:543–548
  2. Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, et al. Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease. Ann. Neurol. 1996;39:800–803
  3. Curran T, D'Arcangelo G. Role of reelin in the control of brain development. Brain Res. Brain Res. Rev. 1998;26:285–294
  4. D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999;24:471–479
  5. DeSilva U, D'Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, et al. The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res. 1997;7:157–164
  6. Ekelund J, Lichtermann D, Hovatta I, Ellonen P, Suvisaari J, Terwilliger JD, et al. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum. Mol. Genet. 2000;9:1049–1057
  7. Fatemi SH. Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Mol. Psychiatry. 2001;6:129–133
  8. Fatemi SH, Earle JA, McMenomy T. Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatry. 2000;5:654–663
  9. Goffinet AM. An early development defect in the cerebral cortex of the reeler mouse: a morphological study leading to a hypothesis concerning the action of the mutant gene. Anat. Embryol. 1979;157:205–216
  10. Guidotti A, Auta J, Davis JM, DiGiorgi Gerevini V, Dwivedi Y, Grayson DR, et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry. 2000;57:1061–1069
  11. Helbecque N, Amouyel P. Very low density lipoprotein receptor in Alzheimer disease. Microsc. Res. Tech. 2000;50:273–277
  12. Helbecque N, Richard F, Cottel D, Neuman E, Guez D, Amouyel P. The very low density lipoprotein (VLDL) receptor is a genetic susceptibility factor for Alzheimer disease in a European Caucasian population. Alzheimer Dis. Assoc. Disord. 1998;12:368–371
  13. Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajarvi R, et al. A genome-wide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am. J. Hum. Genet. 1999;65:1114–1124
  14. Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 1998;95:15718–15723
  15. Oka K, Tzung K-W, Sullivan M, Lindsay E, Baldini A, Chan L. Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9q24 by fluorescence in situ hybridization. Genomics. 1994;20:298–300
  16. Okuizumi K, Onodera O, Namba Y, Ikeda K, Yamamoto T, Seki K, et al. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nat. Genet. 1995;11:207–209
  17. Okuizumi K, Onodera O, Seki K, Tanaka H, Namba Y, Ikeda K, et al. Lack of Association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease. Ann. Neurol. 1996;40:251–254
  18. Ott J. Analysis of Human Genetic Linkage. 3rd edn.. Baltimore: Johns Hopkins Univ. Press; 1999;
  19. Persico AM, D'Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, et al. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol. Psychiatry. 2001;6:150–159
  20. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 1995;59:97–105
  21. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, et al. Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999;97:689–701
  22. Yamanaka H, Kamimura K, Tanahashi H, Takahashi K, Asada T, Tabira T. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. Neurobiol. Aging. 1998;19(1 Suppl.):S43–S46

PII: S0920-9964(01)00398-X

Schizophrenia Research
Volume 58, Issue 1 , Pages 37-41 , 1 November 2002