Schizophrenia Research
Volume 58, Issue 1 , Pages 99-100 , 1 November 2002

Frequency of the 17-bp variable number of tandem repeat polymorphism in Turkish schizophrenic patients

  • Hasan Herken

      Affiliations

    • Corresponding Author InformationCorresponding author. Fax: +90-342-336-5505
    • Department of Psychiatry, Faculty of Medicine Gaziantep University, Kole Jtepe 27100 Gaziantep, Turkey
    • ,
  • M Emin Erdal

      Affiliations

    • Department of Medical Biology and Genetics Faculty of Medicine Gaziantep University, Turkey
    • ,
  • A Şükrü Aynacıoǧlu

      Affiliations

    • Department of Pharmacology, Faculty of Medicine Gaziantep University, Turkey
    • ,
  • Ömer Barlas

      Affiliations

    • Department of Medical Biology and Genetics Faculty of Medicine Gaziantep University, Turkey
    • ,
  • Osman Cataloluk

      Affiliations

    • Department of Medical Biology and Genetics Faculty of Medicine Gaziantep University, Turkey
    • ,
  • Koray Esgi

      Affiliations

    • Department of Psychiatry, Faculty of Medicine Gaziantep University, Kole Jtepe 27100 Gaziantep, Turkey
    • ,
  • Jurgen Brockmöller

      Affiliations

    • Institute of Clinical Pharmacology University Medical Center Charité Humboldt University of Berlin D-10098 Berlin, Germany
    • ,
  • Rolf Kaiser

      Affiliations

    • Institute of Clinical Pharmacology University Medical Center Charité Humboldt University of Berlin D-10098 Berlin, Germany

Received 8 August 2001

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders: IV. Washington: The American Psychiatric Association Press; 1994;
  2. Ball D, Hill L, Freeman B, Eley TC, Strelau J, Riemann R, et al. The serotonin transporter gene and peer-rated neuroticism. NeuroReport. 1997;8:1301–1304
  3. Battersby S, Ogilvie AD, Smith CAD, Blackwood DHR, Muir WJ, Quinn JP, et al. Structure of a variable number repeat of the serotonin transporter gene and association with affective disorder. Psychiatr. Genet. 1996;6:177–181
  4. Bonnet-Brilhault F, Laurent C, Thibaut D, Campion D, Chavand O, Samolyk D, et al. Serotonin transporter gene polymorphism and schizophrenia: an association study. Biol. Psychiatry. 1997;42:634–636
  5. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996;66:2621–2624
  6. Hernandez I, Sokolov BP. Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics. Mol. Psychiatry. 1997;2:57–64
  7. Hranilovic D, Schwab SG, Jernej B, Knapp M, Lerer B, Albus M, et al. Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings. Mol. Psychiatry. 2000;5:91–95
  8. Kaiser R, Tremblay PB, Schmider J, Henneken M, Dettling M, Müller-Oerlinghausen B, et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but association of the 17-bp VNTR with schizophrenia. Mol. Psychiatry. 2001;6:179–185
  9. Naylor L, Dean B, Opeskin K, Pavey G, Hill C, Keks N, et al. Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine. J. Neural Transm.: Gen. Sect. 1996;103:749–757
  10. Serreti A, Catalona M, Smeraldi E. Serotonin transporter gene is not associated with symptomatology of schizophrenia. Schizophr. Res. 1999;35:33–39
  11. Stöber G, Jatzke S, Heils A, Jungkunz G, Fuchs E, Knapp M, et al. Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promotor of serotonin transporter gene. Eur. Arch. Psychiatry Clin. Neurosci. 1998;248:82–86

☆ We are thankful to Dr. İclal Meram, Dr. Hamza Arı, Dr. Murat Fettahlioglu, Dr. Ömer Böke, Dr. Lutfullah Beşiroǧlu, and Dr. Özkan Güler for their great help to collect the blood samples.

PII: S0920-9964(01)00391-7

Schizophrenia Research
Volume 58, Issue 1 , Pages 99-100 , 1 November 2002

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