Schizophrenia Research
Volume 58, Issue 1 , Pages 31-35 , 1 November 2002

A possible association between the genetic predisposition for dizygotic twinning and schizophrenia

  • Ulla Kläning

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +45-77893853; fax: +45-77893859
    • Centre of Clinical Psychiatric Research, Mood Disorder Research Unit, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark
    • ,
  • Carsten Bøcker Pedersen

      Affiliations

    • Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Aarhus University Hospital and the National Centre for Register-based Research, Aarhus University, Denmark
    • ,
  • Preben Bo Mortensen

      Affiliations

    • Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Aarhus University Hospital and the National Centre for Register-based Research, Aarhus University, Denmark
    • ,
  • Kirsten Ohm Kyvik

      Affiliations

    • The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Denmark
    • ,
  • Axel Skytthe

      Affiliations

    • Danish Centre for Demographic Research and the Danish Twin Registry, University of Southern Denmark, Denmark

Received 15 May 2001 ,Accepted 14 September 2001.

References 

  1. Bønnelykke B. Predictors of Human Twinning. An Epidemiological Study of Medical, Social and Demographic Factors in Human Twinning. Risskov: Cytogenetic Laboratory, Aarhus Psychiatric Hospital; 1988;
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  3. Breslow NE, Day NE. Statistical Methods in Cancer Research. The Design and Analysis of Cohort Studies. Lyon: International Agency for Research on Cancer; 1987;
  4. Clayton D, Hills M. Statistical Models in Epidemiology. Oxford: Oxford Univ. Press; 1993;
  5. Kläning U. Greater occurrence of schizophrenia in dizygotic but not monozygotic twins. Register-based study. Br. J. Psychiatry. 1999;175:407–409 [see comments]
  6. Kyvik KO, Christensen K, Skytthe A, Harvald B, Holm NV. The Danish Twin Register. Dan. Med. Bull. 1996;43:467–470
  7. Lichtenstein P, Olausson PO, Källen AJB. Twin births to mothers who are twins: a registry based study. Br. Med. J. 1996;312:879–881
  8. Magnus P, Berg K, Nance WE. Predicting zygosity in Norwegian twin pairs born 1915–1960. Clin. Genet. 1983;24:103–112
  9. Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, et al. Advancing paternal age and the risk of schizophrenia. Arch. Gen. Psychiatry. 2001;58(4):361–367
  10. Malig C. The civil registration system in Denmark. Tech. Pap. IIVRS. 1996;66:1–6
  11. Meulemans WJ, Lewis CM, Boomsma DI, Derom CA, Van den Berghe H, Orlebeke JF, et al. Genetic modelling of dizygotic twinning in pedigrees of spontaneous dizygotic twins. Am. J. Med. Genet. 1996;61:258–263
  12. Mortensen PB, Pedersen CB, Westergaard T, Wohlfahrt J, Ewald H, Mors O, et al. Effects of family history and place and season of birth on the risk of schizophrenia. N. Engl. J. Med. 1999;340:603–608 [see comments]
  13. Munk-Jorgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan. Med. Bull. 1997;44:82–84
  14. Pedersen CB, Mortensen PB. Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis. Br. J. Psychiatry. 2001;179:46–52
  15. Riley BP, McGuffin P. Linkage and associated studies of schizophrenia. Am. J. Med. Genet. 2000;97:23–44
  16. SAS Institute, 1997. The GENMOD procedure. In: SAS/STAT software: Changes and Enhancements through Release 6.12. pp. 247–348.
  17. Westergaard T, Mortensen PB, Pedersen CB, Wohlfahrt J, Melbye M. Exposure to prenatal and childhood infections and the risk of schizophrenia: suggestions from a study of sibship characteristics and influenza prevalence. Arch. Gen. Psychiatry. 1999;56:993–998
  18. World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death. Based on the Recommendations of the Eighth Revision Conference, 1965, and Adopted by the Nineteenth World Health Assembly. Geneva: World Health Organization; 1965;
  19. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organization; 1992;

PII: S0920-9964(01)00343-7

Schizophrenia Research
Volume 58, Issue 1 , Pages 31-35 , 1 November 2002

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