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Schizophrenia Research
Volume 58, Issue 1
, Pages 1-10
, 1 November 2002
Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics
References
- . Significantly reduced level of docosahexaenoic acid and docosapentaenoic acid in erythrocyte membranes from schizophrenia patients compared with a carefully matched control group. Biol. Psychiatry. 2001;49:510–522
- . Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia. Schizophr. Res. 1992;6:1–7
- Structural and functional importance of dietary polyunsaturated fatty acids in the nervous system. Adv. Exp. Med. Biol. 1992;318:211–229
-
.
Free radicals and the developmental pathophysiology of schizophrenic burnout.
Integr. Psychiatry. 1987;5:40–48
- . High fat diets varying in ratio of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. J. Nutr. 1986;116:718–725
- . Fat consumption and schizophrenia. Acta Psychiatr. Scand. 1988;78:587–591
-
.
Is the docosahexaenoic acid (DHA, 22:6n−3) content of erythrocytes a marker for the DHA content of brain phospholipids?.
FASEB J. 1993;7:A152
-
.
Cell membrane essential fatty acid status in drug-naive first-episode psychotic patients and its relation to outcome.
Schizophr. Res. 2001;49:83
- . Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol. Psychiatry. 2000;47:8–21
- . A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases. Schizophr. Res. 1994;12:53–61
- . Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs. Biochem. Pharmacol. 1995;49:359–365
-
.
The relationship between schizophrenia and essential fatty acids and eicosanoid metabolism.
Prostaglandins, Leukotrienes Essent. Fatty Acids. 1992;46:71–77
- . The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr. Res. 1998;30:193–208
-
.
The effects of antipsychotic drugs on membrane phospholipids—a possible novel mechanism of action of clozapine.
In:
Peet M, Glen AL, Horrobin D editor. Phospholipid Spectrum Disorders in Psychiatric. Lancashire, UK: Marius Press; 1999;p. 113–117
- . Red cell membrane fatty acids in schizophrenic patients with mainly positive or mainly negative symptoms. Schizophr. Res. 1993;9:221
- . The membrane hypothesis of schizophrenia. Schizophr. Res. 1994;13:195–208
- . Essential fatty acids in growth and development. Prog. Lipid Res. 1991;30:39–103
-
.
Erythrocyte membrane phospholipids in psychotic patients.
Psychiatry Res. 1993;49:9–95
- . The effects of ischemia and recirculation, hypoxia and recovery on antioxidant factors and β-adrenoreceptor density: is the damage in erythrocytes a reflection of brain damage caused by complete cerebral ischemia and by hypoxia?. Biochem. Biophys. Res. Commun. 1987;149:568–575
- . Smoking and schizophrenia. Schizophr. Res. 1992;8:93–102
-
.
Essential fatty acids in the treatment of schizophrenia.
Drugs Today. 1997;33:5–17
- . Free radical pathology and the antioxidant defense in schizophrenia. Schizophr. Res. 1996;19:1–18
-
.
Oxidative injury and potential use of antioxidants in schizophrenia.
Prostaglandins, Leukotrienes Essent. Fatty Acids. 1996;55:45–54
- . Distribution of plasma membrane phospholipids and cholesterol in skin fibroblasts from drug-naive patients at the onset of psychosis. Schizophr. Res. 1994;13:239–247
- . Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar and normal controls. Psychiatry Res. 1996;63:133–142
-
.
Utilization of precursor essential fatty acids in culture by skin fibroblasts from schizophrenic patients and normal controls.
Prostaglandin, Leukotrienes Essent. Fatty Acids. 1996;55:65–70
- . Elevated plasma lipid peroxides at the onset of non-affective psychosis. Biol. Psychiatry. 1998;43:674–679
-
.
Membrane peroxidation and the neuropathology of Schizophrenia.
In:
Horrobin D, Glen AL, Peet M editor. Phospholipid Spectrum Disorders in Psychiatric. Lancashire, UK: Marius Press; 1999;p. 99–111
-
.
Cultural and socioeconomic differences in dietry intak of essential fatty acids and antioxidants—effects on the outcome.
In:
Horrobin D, Glen AL, Peet M editor. Phospholipid Spectrum Disorders in Psychiatric. Lancashire, UK: Marius Press; 1999;p. 167–179
- . Oxidative stress and the role of antioxidant and w−3 essential fatty acid supplementation in schizophrenia. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2001;25:463–493
-
.
Neuroprotective action of atypical antipsychotics in schizophrenia: improved cognitive performance and underlying mechanism of action.
Schizophr. Res. 2001;49:94
- . The Nithsdale Schizophrenia Surveys XIV: plasma lipid peroxide and serum vitamin E levels in patients with and without tardive dyskinesia and in normal subjects. Br. J. Psychiatry. 1995;170:1–8
- . Brief psychiatry rating scale. Psychol. Rep. 1962;10:799–812
- . Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment. Int. Clin. Psychopharmacol. 1993;8:151–153
-
.
Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation.
Prostaglandins, Leukotrienes Essent. Fatty Acids. 1996;55:119–122
- . Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr. Res. 2001;49:243–251
- . Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex using in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch. Gen. Psychiatry. 1991;48:563–568
-
.
Cigarette smoking and antioxidant status in schizophrenia.
Biol. Psychiatry. 1998;43:112S–113S
-
.
Free radical pathology in schizophrenia: a review.
Prostaglandins, Leukotrienes Essent. Fatty Acids. 1996;55:33–43
-
.
Phospholipid and prostaglandin hypotheses of schizophrenia.
In:
Meltzer HY editors. Psychopharmacology: The Third Generation of Progress. New York: Raven Press; 1987;
- . Smoking habits and plasma lipid peroxides and vitamin E in never medicated first-episode schizophrenic patients with schizophrenia. Br. J. Psychiatry. 2000;176:290–293
- . An in vivo study of the prefrontal cortex of schizophrenic patients at different age of illness via phosphorous magnetic resonance spectroscopy. Arch. Gen. Psychiatry. 1995;52:399–406
-
.
The Regulation of Membrane Lipid Metabolism. 2nd edn.. Boca Raton, FL: CRC Press; 1992;
- . A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. Psychiatry Res. 1989;27:313–323
- . Do essential fatty acids play a role in brain and behavioral development?. Neurosci. Biobehav. Rev. 1992;16:193–205
-
.
Red blood cell and platelet fatty acid metabolism in schizophrenia.
In:
Horrobin D, Glen AL, Peet M editor. Phospholipid Spectrum Disorders in Psychiatric. Lancashire, UK: Marius Press; 1999;p. 57–71
- . Red cell membrane dynamics in schizophrenia: II. Fatty acid composition. Schizophr. Res. 1994;13:217–226
PII: S0920-9964(01)00334-6
© 2002 Elsevier Science B.V. All rights reserved.
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Schizophrenia Research
Volume 58, Issue 1
, Pages 1-10
, 1 November 2002
