Schizophrenia Research
Volume 56, Issue 1 , Pages 25-30 , 1 July 2002

Sexual side effects of novel antipsychotic medications

  • Donna A Wirshing

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    • Department of Psychiatry, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Psychiatry, West Los Angeles Veterans Affairs Medical Centre, Building 210B, Room 15, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Tel.: +1-310-268-3037; fax: +1-310-312-0572
    • ,
  • Joseph M Pierre

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    • Department of Psychiatry, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    • ,
  • Stephen R Marder

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    • Department of Psychiatry, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    • ,
  • C.Scott Saunders

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    • Department of Psychiatry, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    • ,
  • William C Wirshing

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    • Department of Psychiatry, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA

Received 20 December 2000 ,Revised 25 May 2001 ,Accepted 29 May 2001.

References 

  1. Aizenberg D, Zemishlany Z, Dorfman-Etrog P, Weizman A. Sexual dysfunction in male schizophrenic patients. J. Clin. Psychiatry. 1995;56:137–141
  2. Andreason NC. Scale for the assessment of negative symptoms (SANS). Br. J. Psychiatry. 1989;155(Suppl. 7):53–58
  3. Breier AF, Malhotra AK, Su T, Pinals DA, Elman I, Adler CM, et al.  Clozapine and risperidone in chronic schizophrenia: effects on symptoms, parkinsonian side effects, and neuroendocrine response. Am. J. Psychiatry. 1999;156:294–298
  4. Burke MA, McEvoy JP, Ritchie JC. A pilot study of a structured interview addressing sexual function in men with schizophrenia. Biol. Psychiatry. 1994;35:32–35
  5. Fleischhacker WW, Meise U, Gunther V, Kurz M. Compliance with antipsychotic drug treatment: influence of side effects. Acta Psychiatr. Scand. Suppl. 1994;382:11–15
  6. Friedman S, Harrison G. Sexual histories, attitudes and behavior of schizophrenic and normal women. Arch. Sex. Behav. 1984;13:555–567
  7. Ghadirian AM, Chouinard G, Annable L. Sexual dysfunction and plasma prolactin levels in neuroleptic treated schizophrenic outpatients. J. Nerv. Ment. Dis. 1982;170:463–467
  8. Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW. Sexual disturbances during clozapine and haloperidol treatment for schizophrenia. Am. J. Psychiatry. 1999;156:631–633
  9. Kane JM, Cooper TB, Sachar EJ, Halpern FS, Bailine S. Clozapine: plasma levels and prolactin response. Psychopharmacology. 1981;73:184–187
  10. Kleinberg DL, Davis JM, De Coster R, Van Baelen B, Brecher M. Prolactin levels and adverse events in patients treated with risperidone. J. Clin. Psychopharmacol. 1999;19:57–61
  11. Kotin J, Wilbert DE, Verburg D, Seldinger SM. Thioridazine and sexual dysfunction. Am. J. Psychiatry. 1976;133:82–85
  12. Overall JE, Gorham DR. The brief psychiatric rating scale (BPRS): recent developments in ascertaining and scaling. Psychopharmacol. Bull. 1988;24:97–99
  13. SAS Institute Inc. . SAS ProcGLM (Procedure General Linear Model). Cary, NC: SAS Institute; 1992;
  14. Wirshing DA, Erhart SM, Pierre JM, Boyd JA. Non-EPS related side effects of novel antipsychotics. Curr. Opin. Psychiatry. 2000;13:45–50

☆ This research was supported in part by a V.A. Type 2 Merit Review Award and a NARSAD Young Investigator Award.

PII: S0920-9964(01)00271-7

doi: 10.1016/S0920-9964(01)00271-7

Schizophrenia Research
Volume 56, Issue 1 , Pages 25-30 , 1 July 2002

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