Schizophrenia Research
Volume 52, Issue 3 , Pages 171-179 , 1 December 2001

Karyotype analysis of 161 unrelated schizophrenics: no increased rates of X chromosome mosaicism or inv(9), using ethnically matched and age-stratified controls

  • Tomoko Toyota

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • Department of Neuropsychiatry, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Hiromitsu Shimizu

      Affiliations

    • Department of Neuropsychiatry, Hokushin General Hospital, Nagano, Japan
    • ,
  • Kazuo Yamada

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • ,
  • Kiyoshi Yoshitsugu

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • Asai Hospital, Chiba, Japan
    • ,
  • Joanne Meerabux

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • ,
  • Eiji Hattori

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • ,
  • Tetsuya Ichimiya

      Affiliations

    • Haryugaoka Hospital, Fukushima, Japan
    • ,
  • Takeo Yoshikawa

      Affiliations

    • Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-484675968; fax: +81-484675916

Received 24 July 2000 ,Accepted 15 December 2000.

References 

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  3. Bassett AS. Chromosomal aberrations and schizophrenia. Br. J. Psychiatry. 1992;161:323–334
  4. DeLisi LE, Friedrich U, Wahlstrom J, Boccio-Smith A, Forsman A, Eklund K, et al. Schizophrenia and sex chromosome anomalies. Schizophr. Bull. 1994;20:495–505
  5. Gardner RJM, Sutherland GR. Chromosomal abnormalities and genetic counselling. In:  Motulsky AG,  Bobrow M,  Harper PS,  Scriver C editor. Oxford Monographs on Medical Genetics. Oxford: Oxford University Press; 1989;p. 68–79
  6. Guttenbach M, Koschorz B, Bernthaler U, Grimm T, Schmid M. Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei. Am. J. Hum. Genet. 1995;57:1143–1150
  7. Hsu LYF, Benn PA, Tannenbaum HL, Perlis TE, Carlson AD. Chromosomal polymorphisms of 1, 9, 16 and Y in 4 major ethnic groups: a large prenatal study. Am. J. Med. Genet. 1987;26:95–101
  8. Kaplan AR. Chromosomal mosaicisms and occasional acentric chromosomal fragments in schizophrenic patients. Biol. Psychiatry. 1970;2:89–94
  9. Ko TM, Hsieh FJ, Chang LS, Pan MF, Lee TY. Pericentric inversions of chromosome 9 in Taiwanese fetuses. J. Formos. Med. Assoc. 1992;91:473–474
  10. Kumra S, Wiggs E, Krasnewich D, Meck J, Smith ACM, Bedwell J, et al. Brief report: association of sex chromosome anomalies with childhood-onset psychotic disorders. J. Am. Acad. Child Adolesc. Psychiatry. 1998;37:292–296
  11. Kunugi H, Lee KB, Nanko S. Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9. Schizophr. Res. 1999;40:43–47
  12. Matsuda T, Horii Y, Hayashi K, Yoshida O. Quantitative analysis of seminiferous epithelium in subfertile carriers of chromosomal translocations. Int. J. Fertil. 1991;36:344–351
  13. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CAM, et al. Disruption of two novel genes by a translocation cosegregating with schizophrenia. Hum. Mol. Genet. 2000;9:1415–1423
  14. In:  Mitelman F editors. An International System for Human Cytogenetic Nomenclature. Basel: Karger; 1995;
  15. Nanko S, Kunugi H, Sasaki T, Fukuda R, Kawate T, Kazamatsuri H. Pericentric region of chromosome 9 is a possible candidate region for linkage study of schizophrenia. Biol. Psychiatry. 1993;33:655–658
  16. Nowinski GP, Van Dyke DL, Tilly BC, Jacobsen G, Babu VR, Worsham MJ, et al. The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history. Am. J. Hum. Genet. 1990;46:1101–1111
  17. Serra A, Brahe C, Millington-Ward A, Neri G, Tedeschi B, Tassone F, et al. Pericentric inversion of chromosome 9: prevalence in 300 Down syndrome families and molecular studies of nondisjunction. Am. J. Med. Genet. 1990;7:162–168
  18. Sham PC, Curtis D. Monte-Carlo tests for association between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 1995;59:97–105
  19. Smith AB, Peterson P, Wieland J, Moriarty T, DeLisi LE. Chromosome 18 translocation (18;21) (p11.1;p11.1) associated with psychosis in one family. Am. J. Med. Genet. (Neuropsychiatric Genet.). 1996;67:560–563
  20. Smyth CM, Bremner WJ. Klinefelter syndrome. Arch. Intern. Med. 1998;158:1309–1314
  21. Stone JF, Sandberg AA. Sex chromosome aneuploidy and aging. Mutation Res. 1995;338:107–113
  22. Yamada K. Population studies of inv(9) chromosomes in 4300 Japanese: incidence, sex difference and clinical significance. Jpn. J. Hum. Genet. 1992;37:293–301
  23. Yoshida A, Miura K, Shirai M. Cytogenetic survey of 1007 infertile males. Urol. Int. 1997;58:166–176

PII: S0920-9964(01)00151-7

Schizophrenia Research
Volume 52, Issue 3 , Pages 171-179 , 1 December 2001

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