Schizophrenia Research
Volume 52, Issue 3 , Pages 167-170 , 1 December 2001

Screening for 22q11 deletions in a schizophrenia population

  • T. Arinami

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-298-53-3352; fax: +81-298-53-3333
    • ,
  • T. Ohtsuki

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • K. Takase

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • H. Shimizu

      Affiliations

    • Hokushin General Hospital, Nakano 383-8505, Japan
    • ,
  • T. Yoshikawa

      Affiliations

    • Laboratory for Molecular Psychiatry, RIEKN Brain Science Institute, Wako 351-0198, Japan
    • ,
  • H. Horigome

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • ,
  • J. Nakayama

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • ,
  • M. Toru

      Affiliations

    • Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Tokyo 113-8510, Japan

Received 21 October 2000 ,Accepted 4 December 2000.

References 

  1. Bassett AS. Chromosomal aberrations and schizophrenia. Autosomes. Br. J. Psychiatry. 1992;161:323–334
  2. Bassett AS, Hodgkinson K, Chow EWC, Correia S, Scutt LE, Weksberg R. 22q11 deletion syndrome in adults with schizophrenia. Am. J. Med. Genet. 1998;81:328–337
  3. Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, et al. Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders. Am. J. Hum. Genet. 1997;60:851–859
  4. Carlson C, Sirotkin H, Pandita R, Goldberg R, McKie J, Wadey R, et al. Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am. J. Hum. Genet. 1997;61:620–629
  5. de Chaldee M, Laurent C, Thibaut F, Martinez M, Samolyk D, Petit M, et al. Linkage disequilibrium on the COMT gene in French schizophrenics and controls. Am. J. Med. Genet. 1999;88:452–457
  6. Chow LY, Merce GB, Wing YK, Fung KP, Lee CY, Ungvari GS, et al. Schizophrenia and deletion at 22q11 in Hong Kong Chinese. Am. J. Med. Genet. 1997;74:677
  7. Goldberg R, Motzkin B, Marion R, Scambler PJ, Shprintzen RJ. Velo-cardio-facial syndrome: a review of 120 patients. Am. J. Med. Genet. 1993;45:313–319
  8. Karayiorgou M, Morris MA, Morrow B, Shprintzen RJ, Goldberg R, Borrow J, et al  Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc. Natl Acad. Sci. USA. 1995;92:7612–7616
  9. Karayiorgou M, Galke B, Budarf M, Nestadt G, Antonarakis SE, Kazazian HH, et al. Further characterization of the 22q11 schizophrenia susceptibility locus. Am. J. Med. Genet. 1997;74:677
  10. Kunugi H, Vallada HP, Sham PC, Hoda F, Arranz MJ, Li T, et al. Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr. Genet. 1997;7:97–101
  11. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6:243–250
  12. du Montcel ST, Mendizabal H, Ayme S, Levy A, Philip N. Prevalence of 22q11 microdeletion. J. Med. Genet. 1996;33:719
  13. Morrow B, Goldberg R, Carlson C, Das Gupta R, Sirotkin H, Collins J, et al  Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome. Am. J. Hum. Genet. 1995;56:1391–1403
  14. Ohmori O, Shinkai T, Kojima H, Terao T, Suzuki T, Mita T, et al. Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci. Lett. 1998;243:109–112
  15. Shprintzen RJ, Goldberg R, Golding-Kushner KJ, Marion RW. Late-onset psychosis in the velo-cardio-facial syndrome. Am. J. Med. Genet. 1992;42:141–142
  16. Sugama S, Namihira T, Matsuoka R, Taira N, Eto Y, Maekawa K. Psychiatric inpatients and chromosome deletions within 22q11.2. J. Neurol. Neurosurg. Psychiatry. 1999;67:803–806
  17. Thomas JA, Graham JMJ. Chromosome 22q11 deletion syndrome: an update and review for the primary pediatrician. Clin. Pediatr. 1997;36:253–266
  18. Usiskin SI, Nicolson R, Krasnewich DM, Yan W, Lenane M, Wudarsky M, et al. Velocardiofacial syndrome in childhood-onset schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry. 1999;38:1536–1543

PII: S0920-9964(00)00192-4

Schizophrenia Research
Volume 52, Issue 3 , Pages 167-170 , 1 December 2001

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