Schizophrenia Research
Volume 90, Issue 1 , Pages 62-70, February 2007

Dynamic mapping of hippocampal development in childhood onset schizophrenia

  • Tom F. Nugent III

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • David H. Herman

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Anna Ordonez

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Deanna Greenstein

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Kiralee M. Hayashi

      Affiliations

    • Laboratory of Neuro Imaging, Department Neurology, UCLA School of Medicine, Los Angeles, CA, United States
    • ,
  • Marge Lenane

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Liv Clasen

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • David Jung
    • ,
  • Arthur W. Toga

      Affiliations

    • Laboratory of Neuro Imaging, Department Neurology, UCLA School of Medicine, Los Angeles, CA, United States
    • ,
  • Jay N. Giedd

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Judith L. Rapoport

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • ,
  • Paul M. Thompson

      Affiliations

    • Laboratory of Neuro Imaging, Department Neurology, UCLA School of Medicine, Los Angeles, CA, United States
    • ,
  • Nitin Gogtay

      Affiliations

    • Child Psychiatry Branch, NIMH, Bethesda, United States
    • Corresponding Author InformationCorresponding author. Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N 202, Bethesda, MD 20892, United States. Tel.: +1 301 435 4494.

Received 20 September 2006; received in revised form 26 October 2006; accepted 30 October 2006. published online 12 December 2006.

Abstract 

Prior cross-sectional anatomic brain imaging studies of the hippocampus in schizophrenia have generally shown loss in total hippocampal volume although the progressive course of these changes remains unknown. We report the first prospective sub-regional maps of hippocampal development in childhood onset schizophrenia (COS), reconstructed from serial brain MRI scans of 29 children with COS scanned every 2 years (87 scans) and compared to 31 controls matched for age, sex, and scan interval (94 scans). As expected, the COS subjects showed significant bilateral deficits (9–10%) in total hippocampal volume which remained consistent between age 9 and 26. However sub-regional maps showed heterogeneous changes with loss of hippocampal volume in both anterior as well as posterior ends while the body of the hippocampus gained in volume suggesting that hippocampal subunits are differentially affected in schizophrenia.

Keywords: Childhood onset schizophrenia, MRI, Mapping, Hippocampus, Longitudinal

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PII: S0920-9964(06)00456-7

doi:10.1016/j.schres.2006.10.014

Schizophrenia Research
Volume 90, Issue 1 , Pages 62-70, February 2007

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