Family history of autoimmune diseases in psychosis

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Abstract

The mothers of 101 psychotic patients and 116 normal controls were interviewed using a semi-structured questionnaire designed to determine the presence or absence of autoimmune disorders in first degree relatives of the probands. Thyrotoxicosis and insulin-dependent diabetes mellitus were significantly more common in the relatives of the psychotic patients than in the control relatives; in particular thyrotoxicosis was more frequent in the mothers of patients (11%) than the mothers of controls (2.6%). None of the examined characteristics of the patients, including RDC-diagnosis, family history of psychosis, age at onset of psychosis and winter birth, was predictive of thyrotoxicosis- and insulin-dependent diabetes mellitus in relatives.

References (59)

  • C.E. Barr et al.

    Exposure to influenza epidemics during gestation and adult schizophrenia: A 4-year study

    Arch. Gen. Psych.

    (1990)
  • E.D. Bartels

    Heredity in Graves' Disease

    (1941)
  • P. Bebbington et al.

    Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study

    Br. J. Psychiatry

    (1993)
  • T.N. Bradbury et al.

    Season of birth in schizophrenia: A review of the evidence, methodology and etiology

    Psych. Bull.

    (1985)
  • M. Carter et al.

    Possible biological advantages among schizophrenic' relatives

    Br. J. Psych.

    (1971)
  • C.L. Cazzullo et al.

    The leucocyte antigenic system HLA as a possible genetic marker of schizophrenia

    Br. J. Psych.

    (1974)
  • F. Chiappelli

    The ‘Stress Analogy’, in the context of psychoneuroimmunology

    Schizophr. Bull.

    (1988)
  • C.E. Coffey et al.

    T-lymphocytes in schizophrenia

    Biol. Psych.

    (1983)
  • R.R. Crowe et al.

    HLA antigens and schizophrenia

    Arch. Gen. Psych.

    (1979)
  • J. Dean et al.

    Epi Info version 5.01a

    (1991)
  • F.M. Delange

    Relation of thyroid hormones to human brain development

  • L.E. DeLisi et al.

    Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients

    Br. J. Psych.

    (1981)
  • L.E. DeLisi et al.

    Deficient natural killer cell (NK) activity and macrophage functioning in schizophrenic patients

    J. Neur. Trans.

    (1983)
  • L.E. DeLisi et al.

    Lymphocyte subpopulations in schizophrenic patients

    Biol. Psych.

    (1982)
  • L. Eaves et al.

    Genetics, Immunology and Virology

    Schizophr. Bull.

    (1988)
  • R. Ganguli et al.

    Clinical and laboratory evidence of autoimmunity in acute schizophrenia

    Ann. NY Acad. Sci.

    (1987)
  • R. Ganguli et al.

    Immune abnormalities in schizophrenia: evidence for the autoimmune hypothesis

    Harvard Rev. Psychiatry

    (1994)
  • J. Huxley et al.

    Schizophrenia as a genetic morphism

    Nature

    (1964)
  • P.B. Jones et al.

    Premorbid social underachievement in schizophrenia. Results from the Camberwell Collaborative Psychosis Study

    Br. J. Psych.

    (1993)
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